<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0212-1611</journal-id>
<journal-title><![CDATA[Nutrición Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Nutr. Hosp.]]></abbrev-journal-title>
<issn>0212-1611</issn>
<publisher>
<publisher-name><![CDATA[Grupo Arán]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0212-16112021000700024</article-id>
<article-id pub-id-type="doi">10.20960/nh.03631</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Potential mental and physical benefits of supplementation with a high-dose, B-complex multivitamin/mineral supplement: what is the evidence?]]></article-title>
<article-title xml:lang="es"><![CDATA[Posibles beneficios mentales y físicos de la suplementación con un preparado multivitamínico/mineral del complejo B en dosis altas: ¿qué evidencia hay?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sarris]]></surname>
<given-names><![CDATA[Jerome]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mehta]]></surname>
<given-names><![CDATA[Bincy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Óvári]]></surname>
<given-names><![CDATA[Veronika]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreres Giménez]]></surname>
<given-names><![CDATA[Inmaculada]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Western Sydney University NICM Health Research Institute ]]></institution>
<addr-line><![CDATA[Penrith New South Wales]]></addr-line>
<country>Australia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,University of Melbourne The Melbourne Clinic Department of Psychiatry]]></institution>
<addr-line><![CDATA[Melbourne ]]></addr-line>
<country>Australia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Greystanes  ]]></institution>
<addr-line><![CDATA[ New South Wales]]></addr-line>
<country>Australia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Bayer Consumer Care AG  ]]></institution>
<addr-line><![CDATA[Basel ]]></addr-line>
<country>Switzerland</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Sant Joan Despí Consumer Health Bayer Hispania, S. L]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>38</volume>
<numero>6</numero>
<fpage>1277</fpage>
<lpage>1286</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0212-16112021000700024&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0212-16112021000700024&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0212-16112021000700024&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: to perform a systematic literature review to examine the effects of high-dose, B-complex multivitamin/mineral supplementation on physical, mental, and energy outcomes in healthy and &#8216;at-risk' (suboptimal nutritional status/subclinical symptoms at baseline) adult populations.  Methods: PubMed was searched for relevant randomized controlled trials until January 2020.  Results: overall, 136 publications were identified. In the seven randomised, double-blind, placebo-controlled studies considered eligible for inclusion, supplementation in healthy populations predominantly showed improvements in perceived stress, physical stamina, concentration, and general mental health, and significant reductions in anxiety and improvements in self-reported vigour. However, not all of these outcomes were significant, and statistical correction for multiple outcomes was not commonly employed. Studies investigating brain mapping following supplementation indicated increased functional activity in brain regions related to processing of attention, executive control, and working memory during cognitive tasks.  Conclusions: while there is certainly a need for further studies on the neurocognitive and physical benefits of micronutrient supplementation, this review provides generally supportive evidence for the benefits of a high-dose, B-complex multivitamin/mineral supplement in healthy and at-risk populations in terms of physical, mental, and energy outcomes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: realizar una revisión sistemática de la literatura para valorar los efectos de la administración de suplementos multivitamínicos/minerales del complejo B en dosis altas sobre los resultados físicos, mentales y energéticos en poblaciones adultas sanas y en situaciones especiales de riesgo (estado nutricional subóptimo/síntomas subclínicos al inicio del estudio).  Métodos: se realizaron búsquedas en PubMed de ensayos controlados aleatorios relevantes hasta enero de 2020.  Resultados: en total se identificaron 136 publicaciones. En los siete estudios aleatorizados, doble ciego y controlados con placebo considerados elegibles para la inclusión, la suplementación en poblaciones sanas mostró predominantemente mejoras en la percepción del estrés, la resistencia física, la concentración y la salud mental general, así como una reducción significativa de la ansiedad y mejoras en la vitalidad según la autoevaluación de los participantes. Sin embargo, no todos estos resultados fueron significativos y la corrección estadística para múltiples resultados no se empleó habitualmente. Los estudios sobre el mapeo cerebral después de la suplementación, indicaron un aumento de la actividad funcional en las regiones del cerebro relacionadas con el procesamiento de la atención, el control ejecutivo y la memoria de trabajo durante tareas cognitivas.  Conclusiones: si bien ciertamente existe la necesidad de realizar más estudios sobre los beneficios neurocognitivos y físicos de la suplementación con micronutrientes, esta revisión proporciona evidencia en general sobre los beneficios de un suplemento multivitamínico/mineral del complejo B en dosis altas, en poblaciones sanas y en situaciones de riesgo, en términos de resultados físicos, mentales y energéticos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[B vitamins]]></kwd>
<kwd lng="en"><![CDATA[Energy]]></kwd>
<kwd lng="en"><![CDATA[Mental outcomes]]></kwd>
<kwd lng="es"><![CDATA[Vitaminas B]]></kwd>
<kwd lng="es"><![CDATA[Energía]]></kwd>
<kwd lng="es"><![CDATA[Resultados mentales]]></kwd>
</kwd-group>
</article-meta>
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