<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0212-1611</journal-id>
<journal-title><![CDATA[Nutrición Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Nutr. Hosp.]]></abbrev-journal-title>
<issn>0212-1611</issn>
<publisher>
<publisher-name><![CDATA[Grupo Arán]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0212-16112023000800010</article-id>
<article-id pub-id-type="doi">10.20960/nh.04621</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto de un multivitamínico sobre la resistencia a la insulina, inflamación y estrés oxidante en un modelo de obesidad inducida en ratas Wistar]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of a multivitamin on insulin resistance, inflammation, and oxidative stress in a Wistar rat model of induced obesity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palma-Jacinto]]></surname>
<given-names><![CDATA[José Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santiago-Roque]]></surname>
<given-names><![CDATA[Isela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coutiño-Rodríguez]]></surname>
<given-names><![CDATA[Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arroyo-Helguera]]></surname>
<given-names><![CDATA[Omar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Veracruzana Centro de Investigaciones Biomédicas ]]></institution>
<addr-line><![CDATA[Xalapa Veracruz]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Veracruzana Laboratorio de Bioquímica y Neurotoxicología ]]></institution>
<addr-line><![CDATA[Xalapa Veracruz]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Veracruzana Public Health Institute ]]></institution>
<addr-line><![CDATA[Xalapa Veracruz]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>40</volume>
<numero>6</numero>
<fpage>1183</fpage>
<lpage>1191</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0212-16112023000800010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0212-16112023000800010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0212-16112023000800010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: la acumulación excesiva de tejido adiposo se acompaña de alteraciones en el estado inflamatorio y aumento del estrés oxidativo, variables que se asocian con la resistencia a la insulina y el incremento en los niveles de glucosa e insulina. Por otro lado, las vitaminas y minerales refuerzan la capacidad antioxidante e inflamatoria, por lo que planteamos que podrían coadyuvar en el control de la resistencia a la insulina y en el metabolismo de la glucosa y lípidos en un modelo de obesidad en rata.  Objetivo: analizar el efecto de un suplemento multivitamínico sobre marcadores de resistencia a la insulina, inflamación y estrés oxidativo en ratas obesas con dieta de cafetería.  Métodos: se dividieron aleatoriamente 35 ratas macho Wistar de 28 días de edad en cuatro grupos: 1, control dieta estándar; 2, dieta estándar más multivitamínico; 3, obesas con dieta de cafetería; y 4, obesas con dieta de cafetería más multivitamínico. Después de los tratamientos se analizaron los niveles de glucosa, HbA1c, insulina, TNF-&#945;, IL-6, estrés oxidativo y perfil de lípidos por métodos colorimétricos, así como el porcentaje de tejido adiposo y los índices Homeostasis Model Assessment (HOMA) y Quantitative Insulin Sensitivity Check Index (QUICKI).  Resultados: el suplemento multivitamínico disminuyó significativamente el tejido adiposo visceral, el índice HOMA, la glucosa, la HbA1c, el estrés oxidante y los marcadores inflamatorios en el grupo obeso más multivitamínico, en comparación con el grupo obeso con dieta de cafetería y el grupo control con dieta estándar. Sin embargo, en el grupo al que se le administró solo el multivitamínico sin dieta de cafetería aumentaron sus niveles de tejido adiposo total, glucosa y estrés oxidativo, así como el índice QUICKI con relación al grupo control con dieta estándar.  Conclusión: la coadministración de un suplemento multivitamínico puede mejorar la sensibilidad a la insulina, el metabolismo de glucosa y el perfil de lípidos; fortalecer el estado antioxidante; y disminuir la inflamación durante el incremento de peso. Sin embargo, no se esperaba que los azúcares añadidos en el suplemento multivitamínico también pueden incrementar el tejido adiposo total y los niveles de estrés oxidativo y glucosa, por lo que se sugiere a futuro utilizar multivitamínicos libres de azúcares.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: excessive accumulation of adipose tissue is accompanied by alterations in the inflammatory state and increased oxidative stress, and these variables are associated with insulin resistance and increased glucose and insulin levels. On the other hand, vitamins and minerals reinforce the antioxidant and inflammatory capacity, for this reasons we propose that they could contribute to the control of insulin resistance, glucose and lipid metabolism in a rat model of obesity.  Objective: to analyze the effect of a multivitamin supplement on markers of insulin resistance, inflammation, and oxidative stress in obese rats on a cafeteria diet.  Methods: thirty-five 28-day-old male Wistar rats were randomly divided into four groups: 1, standard diet control; 2, standard diet plus multivitamin; 3, obese on a cafeteria diet; and 4, obese on a cafeteria diet plus multivitamin. After the treatments, glucose levels, HbA1c, insulin, TNF-&#945;, IL-6, oxidative stress and lipid profile were analyzed by colorimetric methods, as well as the percentage of adipose tissue, Homeostasis Model Assessment (HOMA) index y Quantitative Insulin Sensitivity Check Index (QUICKI).  Results: multivitamin supplementation significantly decreased visceral adipose tissue, HOMA index, glucose, HbA1c, oxidant stress, and inflammatory markers in the obese plus multivitamin rat group, compared with the obese cafeteria diet rat group and the standard diet rat control group. However, the group that was administered only the multivitamin without the cafeteria diet had increased levels of total adipose tissue, glucose, and oxidative stress, as well as the QUICKI index relative to the control group with the standard diet.  Conclusion: co-administration of a multivitamin supplement may improve insulin sensitivity, glucose metabolism and lipid profile; strengthen antioxidant status; and decrease inflammation during weight gain. However, it was not expected that added sugars in multivitamin supplement can also increase total adipose tissue, oxidative stress and glucose levels, so it is suggested to use sugar-free multivitamins in the future.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Multivitamínico]]></kwd>
<kwd lng="es"><![CDATA[Estrés oxidativo]]></kwd>
<kwd lng="es"><![CDATA[Inflamación]]></kwd>
<kwd lng="es"><![CDATA[Sensibilidad a insulina]]></kwd>
<kwd lng="es"><![CDATA[Obesidad inducida]]></kwd>
<kwd lng="en"><![CDATA[Dietary supplement]]></kwd>
<kwd lng="en"><![CDATA[Oxidative stress]]></kwd>
<kwd lng="en"><![CDATA[Inflammation]]></kwd>
<kwd lng="en"><![CDATA[Insulin sensitivity]]></kwd>
<kwd lng="en"><![CDATA[Obesity]]></kwd>
</kwd-group>
</article-meta>
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