<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0212-1611</journal-id>
<journal-title><![CDATA[Nutrición Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Nutr. Hosp.]]></abbrev-journal-title>
<issn>0212-1611</issn>
<publisher>
<publisher-name><![CDATA[Grupo Arán]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0212-16112024000800007</article-id>
<article-id pub-id-type="doi">10.20960/nh.05177</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectos del zinc y resveratrol como moduladores de la respuesta a la leptina en adultos con obesidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Effects of zinc and resveratrol as modulators of leptin response in adults with obesity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Portillo-Siqueiros]]></surname>
<given-names><![CDATA[Erika Yanet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santellano-Estrada]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Villalobos]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roacho-Soto]]></surname>
<given-names><![CDATA[María Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Flórez]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="Ab"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Chihuahua Facultad de Enfermería y Nutriología ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Chihuahua Facultad de Zootécnica y Ecología ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Chihuahua Facultad de Ciencias Químicas ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Europea del Atlántico  ]]></institution>
<addr-line><![CDATA[Santander ]]></addr-line>
<country>España</country>
</aff>
<aff id="A4b">
<institution><![CDATA[,Universidad de León  ]]></institution>
<addr-line><![CDATA[León ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<volume>41</volume>
<numero>5</numero>
<fpage>968</fpage>
<lpage>975</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0212-16112024000800007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0212-16112024000800007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0212-16112024000800007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: el tejido graso es un órgano con función endocrina donde se identifica la hormona leptina (LEP). Este péptido regula el apetito, el sistema inmunológico, las funciones vasculares y la sensibilidad a la insulina. El zinc (Zn) y el resveratrol (RES) tienen efectos potenciales sobre el tejido adiposo.  Objetivo: conocer si la administración combinada de Zn y RES tiene algún efecto sobre la cuantificación de la leptina en sangre en personas con obesidad.  Métodos: estudio experimental longitudinal, diseño ensayo clínico controlado, aleatorio, doble ciego. Formación aleatoria de cuatro grupos: T1 (Zn 50 mg), T2 (control), T3 (RES 500 mg), T4 (Zn 50 mg y RES 500 mg) con un período de suplementación de 60 días. Se tomaron muestras sanguíneas y se cuantificaron glucosa (GLU), leptina (LEP) y lípidos (HDL, LDL, TGL) antes y después de la exposición a los elementos del estudio.  Resultados: edad 34 (± 7) años. En pruebas T, significancia en GLU (p = 0,04) y LEP (p = 0,055). Por grupos de exposición: GLU en T1 (p = 0,03) y T2 (p = 0,031); en la LEP, el T4 (p = 0,024). Lípidos por grupos: HDL en T3 (p = 0,039) y T4 (p = 0,014). ANOVA, HDL (p = 0,06). Pearson, HDL (p = 0,07) y LDL (p = 0,09).  Conclusión: el zinc y el resveratrol demostraron ser agentes prometedores en la modulación de la señalización de la leptina y la glucosa, lo que confirma que funcionan de manera proporcional y brindan beneficios para la salud cardíaca, aunque se necesita más tiempo de exposición para ver si afectan a la homeostasis del equilibrio energético.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: fat tissue is an organ with endocrine function, where the hormone leptin (LEP) is identified. This peptide regulates appetite, the immune system, vascular functions and insulin sensitivity. Zinc (Zn) and resveratrol (RES) have potential effects on adipose tissue.  Objective: to know if the combined administration of Zn and RES has any effect on blood leptin quantification in obese people.  Methods: longitudinal experimental study, controlled clinical trial design, randomized, double blind. Randomized formation of four groups: T1 (Zn 50 mg), T2 (control), T3 (RES 500 mg), T4 (Zn 50 mg and RES 500 mg) with a supplementation period of 60 days. Blood samples were taken and glucose (GLU), leptin (LEP) and lipids (HDL, LDL, TGL) were quantified before and after exposure to the study elements.  Results: age 34 (± 7) years. In T-tests, significance in GLU (p = 0.04) and LEP (p = 0.055). By exposure groups: GLU at T1 (p = 0.03) and T2 (p = 0.031); at LEP at T4 (p = 0.024). Lipids by groups: HDL at T3 (p = 0.039) and T4 (p = 0.014). ANOVA, HDL (p = 0.06). Pearson, HDL (p = 0.07) and LDL (p = 0.09).  Conclusion: zinc and resveratrol showed promise as agents in modulating leptin and glucose signaling, confirming that they work in a proportional manner and provide benefits for cardiac health, but more exposure time is needed to see if they impact energy balance homeostasis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Adipoquinas]]></kwd>
<kwd lng="es"><![CDATA[Tratamiento de la obesidad]]></kwd>
<kwd lng="es"><![CDATA[Homeostasis energética]]></kwd>
<kwd lng="es"><![CDATA[Suplementación mineral]]></kwd>
<kwd lng="es"><![CDATA[Antioxidante]]></kwd>
<kwd lng="en"><![CDATA[Adipokines]]></kwd>
<kwd lng="en"><![CDATA[Treatment for obesity]]></kwd>
<kwd lng="en"><![CDATA[Energy homeostasis]]></kwd>
<kwd lng="en"><![CDATA[Mineral supplementation]]></kwd>
<kwd lng="en"><![CDATA[Antioxidant]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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