<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0213-9111</journal-id>
<journal-title><![CDATA[Gaceta Sanitaria]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Sanit]]></abbrev-journal-title>
<issn>0213-9111</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0213-91112022000300014</article-id>
<article-id pub-id-type="doi">10.1016/j.gaceta.2021.01.008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alcances de la aleatorización mendeliana para el control de confusores no observables en epidemiología]]></article-title>
<article-title xml:lang="en"><![CDATA[Scope of Mendelian randomization to control for unobserved confounding in epidemiology]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ancira-Moreno]]></surname>
<given-names><![CDATA[Mónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lamadrid-Figueroa]]></surname>
<given-names><![CDATA[Héctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Iberoamericana Departamento de Salud ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Salud Pública Centro de Investigación en Salud Poblacional Dirección de Salud Reproductiva]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>36</volume>
<numero>3</numero>
<fpage>274</fpage>
<lpage>277</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0213-91112022000300014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0213-91112022000300014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0213-91112022000300014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La aleatorización mendeliana es un método epidemiológico propuesto para controlar las asociaciones espurias en los estudios observacionales. Estas asociaciones suelen estar causadas por la confusión derivada de factores sociales, ambientales y de comportamiento, que pueden ser difíciles de medir. La aleatorización mendeliana se basa en la selección de variantes genéticas que se utilizan como variables instrumentales, y que influyen en los patrones de exposición o están asociadas con un fenotipo intermedio de la enfermedad. El presente trabajo pretende discutir cómo seleccionar las variantes genéticas adecuadas como variables instrumentales y presentar las potenciales herramientas metodológicas para lidiar con las limitaciones propias de este método epidemiológico. El uso de variables instrumentales para exposiciones modificables tiene el potencial de atenuar los efectos de limitaciones comunes, como la confusión, cuando se eligen variantes genéticas robustas como variables instrumentales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The Mendelian randomization is an epidemiologic method proposed to control for spurious associations in observational studies. These associations are commonly caused by confusion derived from social, environmental, and behavioral factors, which can be difficult to measure. Mendelian randomization is based on the selection of genetic variants that are used as instrumental variables that influence exposure patterns or are associated with an intermediate phenotype of the disease. The present work aims to discuss how to select the appropriate genetic variants as instrumental variables and to present methodological tools to deal with the limitations of this epidemiological method. The use of instrumental variables for modifiable exposures has the potential to mitigate the effects of common limitations, such as confusion, when robust genetic variants are chosen as instrumental variables.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Aleatorización mendeliana]]></kwd>
<kwd lng="es"><![CDATA[Métodos epidemiológicos]]></kwd>
<kwd lng="es"><![CDATA[Sesgo]]></kwd>
<kwd lng="es"><![CDATA[Confusión]]></kwd>
<kwd lng="es"><![CDATA[Genética]]></kwd>
<kwd lng="es"><![CDATA[Variables instrumentales]]></kwd>
<kwd lng="en"><![CDATA[Mendelian randomization]]></kwd>
<kwd lng="en"><![CDATA[Epidemiologic methods]]></kwd>
<kwd lng="en"><![CDATA[Bias]]></kwd>
<kwd lng="en"><![CDATA[Confounding]]></kwd>
<kwd lng="en"><![CDATA[Genetics]]></kwd>
<kwd lng="en"><![CDATA[Instrumental variables]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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