<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922017000400223</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922017000400002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de tiempos quirúrgicos y transfusiones en pacientes quemados tratados con desbridamiento enzimático]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of surgical times and transfusions in burn patients treated with enzymatic debridement]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ojeda-Regidor]]></surname>
<given-names><![CDATA[Ángela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Méndez]]></surname>
<given-names><![CDATA[José-Ramón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Miranda]]></surname>
<given-names><![CDATA[Álvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casado-Pérez]]></surname>
<given-names><![CDATA[César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario La Paz Servicio de Cirugía Plástica y Quemados ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario La Paz Servicio de Cirugía Plástica y Quemados ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario La Paz Servicio de Cirugía Plástica y Quemados ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Universitario La Paz Servicio de Cirugía Plástica y Quemados ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<volume>43</volume>
<numero>3</numero>
<fpage>223</fpage>
<lpage>230</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922017000400223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922017000400223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922017000400223&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y Objetivo En los últimos años se han publicado resultados que demuestran un desbridamiento enzimático rápido, eficaz y específico de tejidos quemados con el uso de Nexobrid® (Mediwound, Alemania), producto compuesto por un concentrado de enzimas proteolíticas enriquecidas con bromelaína. En este estudio comparamos el uso de Nexobrid® como desbridante enzimático frente a un Grupo Control con tratamiento estándar, con el objetivo de evaluar; en función de la superficie corporal quemada (SCQ), la cantidad de intervenciones quirúrgicas realizadas, la colonización del lecho quirúrgico, la necesidad de escarotomías, así como los requerimientos transfusionales de los pacientes tratados.  Material y Método Estudio retrospectivo con 65 pacientes, edad media de 46.87 años, tratados con Nexobrid® entre septiembre de 2015 y diciembre de 2016. Comparamos con un grupo control de 177 pacientes, edad media de 48.24 años, intervenidos mediante desbridamiento tangencial desde enero a diciembre de 2014. El Grupo Control presenta unas características homogéneas a las del Grupo Nexobrid®. Ambos grupos fueron estratificados en función de su SCQ mayor o menor del 15%.  Resultados Encontramos diferencias estadísticamente significativas (p &lt;0.01) con un menor número de días desde la quemadura y el ingreso hasta la cirugía para el Grupo Nexobrid® independientemente de la SCQ. Obtuvimos diferencias estadísticamente significativas para la cantidad de cirugías (p &lt;0.01) en el subgrupo de SCQ &lt;15%. Evaluamos la colonización sin obtener diferencias estadísticamente significativas entre los grupos. El número de escarotomías en el Grupo Nexobrid® fue significativamente menor que en el Grupo Control para las poblaciones con SCQ &gt;15%. Los requerimientos transfusionales fueron menores en el Grupo Nexobrid® frente al Grupo Control en los pacientes con SCQ &gt; 15% (p &lt;0.05).  Conclusiones Nexobrid® permite reducir el número de cirugías y el tiempo hasta el primer desbridamiento sin aumentar la tasa de colonización respecto al Grupo Control. El desbridamiento enzimático precoz reduce la necesidad de escarotomías en pacientes con SCQ &gt;15%. Finalmente, reduce la necesidad de transfusión sanguínea en pacientes con SCQ mayor del 15%.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background and Objective During the last years, results have been published demonstrating fast, efficient and specific enzymatic debridement of burned tissues with the use of a concentrate of proteolytic enzymes enriched with bromelain (Nexobrid®, Mediwound, Germany). In this study we compare the use of Nexobrid® against a Control Group with standard treatment, in order to evaluate; the number of surgical procedures performed, the colonization of the surgical bed, the need for scarotomies, as well as the number of transfusions of the treated patients according to the total burned surface area (TBSA).  Methods We conduct a retrospective study evaluating 65 patients (mean age 46.87 years) treated with Nexobrid® between September 2015 and December 2016. We compare this population with a control group of 177 patients (mean age 48.24 years) treated with tangential excision from January to December 2014. The Control Group was homogeneous to Nexobridto Nexobrid® Group. Group. Both groups were stratified according to their TBSA in 2 groups: more or less than 15%.  Results We found lesser number of days from burn and hospital admission to the first debridement for the Nexobrid® Group regardless of the burned body surface. Statistically significant differences were obtained for the number of surgeries (p &lt;0.01) in the subgroup with &lt;15% TBSA. We evaluated the colonization without obtaining statistically significant differences between the groups. The number of scarotomies carried out in the Nexobridto Nexobrid® Group. Group was significantly lower than in the Control Group when comparing the populations with &gt;15% TSBA. The transfusion requirements were lower in the Nexobrid® Group compared to the Control Group in patients with &gt;15% TBSA (p &lt;0.05).  Conclusions The use of Nexobrid® allows reducing the number of surgeries and the time elapsed to first debridement without increasing the rate of colonization when compared to the Control Group. Early enzymatic debridement reduces the need for scarotomies in &gt;15% TBSA patients. The use of Nexobrid® reduces the need for blood transfusion in patients with &gt;15% TBSA.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Quemados]]></kwd>
<kwd lng="es"><![CDATA[Desbridamiento]]></kwd>
<kwd lng="es"><![CDATA[Desbridamiento enzimático]]></kwd>
<kwd lng="es"><![CDATA[Bromelaína]]></kwd>
<kwd lng="es"><![CDATA[Transfusión]]></kwd>
<kwd lng="en"><![CDATA[Burns]]></kwd>
<kwd lng="en"><![CDATA[Debridement]]></kwd>
<kwd lng="en"><![CDATA[Enzymatic debridement]]></kwd>
<kwd lng="en"><![CDATA[Bromelain]]></kwd>
<kwd lng="en"><![CDATA[Transfusion]]></kwd>
</kwd-group>
</article-meta>
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