<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922018000200015</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922018000200015</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectos de la relajación muscular perilesional con toxina botulínica Tipo A en la cicatrización de heridas facials postraumáticas]]></article-title>
<article-title xml:lang="en"><![CDATA[Effects of perilesional muscular relaxation with botulinic toxin Type A in cycatrization of post-traumatic facial wounds]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero-Larróvere]]></surname>
<given-names><![CDATA[Milagro C]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Sánchez]]></surname>
<given-names><![CDATA[Emilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto-Montenegro]]></surname>
<given-names><![CDATA[Andrés E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Dr. Domingo Luciani Cirugía Plástica, Reconstructiva, Estética y Maxilofacial ]]></institution>
<addr-line><![CDATA[ Caracas]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>44</volume>
<numero>2</numero>
<fpage>203</fpage>
<lpage>215</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922018000200015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922018000200015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922018000200015&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y Objetivo Las heridas faciales son un importante motivo de consulta de urgencia; el objetivo estético de su tratamiento es primordial. Este estudio busca comprobar el efecto de la toxina botulínica tipo A en la cicatrización de heridas faciales postraumáticas y relacionar este efecto con diferentes variables.  Material y Método Estudio prospectivo, descriptivo, de campo, en el Servicio de Cirugía Plástica y Reconstructiva del Hospital Dr. Domingo Luciani (Caracas, Venezuela). La muestra conformada por 40 pacientes, se dividió en 2 grupos: grupo A al que se le aplicó toxina botulínica perilesional a la herida facial; y el grupo B al que se le administró solución fisiológica. Estudiamos las siguientes variables: sexo, edad, fototipo de piel, profundidad y extensión de la herida, relación con las líneas de tensión de la piel relajada y con las unidades estéticas afectadas. Empleamos una escala visual análoga (EVA) para establecer la puntuación del resultado estético de la cicatriz.  Resultados La distribución por sexo presentó mínima diferencia entre los 2 grupos. El valor promedio de la puntuación del resultado estético fue superior significativamente (P &lt; 0.05) en el grupo A con respecto al valor del grupo B. La cicatrización fue exitosa en el grupo A independientemente de variables como sexo y edad. Los fototipos de piel III y IV, la frente y mejillas, las heridas profundas y aquellas heridas en dirección desfavorable a las líneas de tensión de la piel relajada, mostraron diferencias significativas entre ambos grupos.  Conclusiones La aplicación de toxina botulínica como tratamiento coadyuvante en heridas faciales postraumáticas, sobre todo en aquellos pacientes con fototipo de piel por encima de III, las heridas profundas, con dirección en contra de las líneas de tensión de la piel relajada, y en heridas frontales o centrofaciales, abre nuevos horizontes prometedores para favorecer resultados estéticos en cicatrices faciales postraumáticas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ Background and Objective Facial injuries are an important reason for urgent consultation; the aesthetic objective of its treatment is paramount. This study seeks to verify the effect of botulinum toxin type A in the healing of posttraumatic facial wounds and to relate this effect with different variables.  Methods Prospective, descriptive, field study in the Plastic and Reconstructive Surgery Service of the Dr. Domingo Luciani Hospital (Caracas, Venezuela). The sample consisting of 40 patients was divided into 2 groups: group A was given botulinum toxin, and group B was given physiological solution. The following variables were studied: sex, age, skin phototype, depth and extension of the injury, relationship with relaxed skin tension lines, and affected aesthetic units. The visual analog scale (VAS) was used to establish the score of the aesthetic result of the scar.  Results The average value of the esthetic result score was significantly higher (P &lt;0.05) in group A. Healing was successful in group A regardless of sex and age. The skin phototypes III and IV, the forehead and cheeks, the deep wounds and those in the direction unfavorable to the relaxed skin tension lines, showed significant differences between both groups.  Conclusions The application of botulinum toxin as a coadjutant treatment in post-traumatic facial wounds, especially in those patients with skin phototype above III, deep wounds, directed against the skin&#8217;s tension lines, and frontal or centrofacial wounds , opens new promising horizons to favor aesthetic results in posttraumatic facial scars.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Herida facial]]></kwd>
<kwd lng="es"><![CDATA[Cicatriz facial]]></kwd>
<kwd lng="es"><![CDATA[Cicatrización]]></kwd>
<kwd lng="es"><![CDATA[Toxina botulínica]]></kwd>
<kwd lng="en"><![CDATA[Facial wound]]></kwd>
<kwd lng="en"><![CDATA[Facial scar]]></kwd>
<kwd lng="en"><![CDATA[Scarring]]></kwd>
<kwd lng="en"><![CDATA[Botulinum toxin]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral and Maxilofacial Trauma]]></source>
<year>2005</year>
<edition>Tercera</edition>
<page-range>340</page-range><publisher-loc><![CDATA[Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[WB Saunders]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Clavero]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Trauma facial. Tratado de Cirugía Oral y Maxilofacial]]></source>
<year>2009</year>
<edition>2da</edition>
<page-range>553-90</page-range><publisher-loc><![CDATA[Madrid, España ]]></publisher-loc>
<publisher-name><![CDATA[ARAN]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of botulinum toxin type a to prevent widening of facial scars]]></article-title>
<source><![CDATA[Plast Reconst Surg]]></source>
<year>2006</year>
<volume>117</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>67-89</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gassner]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Sherris]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemoimmobilization: Improving predictability in the treatment of facial scars]]></article-title>
<source><![CDATA[Plast Reconst Surg]]></source>
<year>2003</year>
<volume>112</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>101-28</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erbguth]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Historical note on the therapeutic use of botulinum toxin in neurological disorders]]></article-title>
<source><![CDATA[J Neurol Neurosurg Psychiatry]]></source>
<year>1996</year>
<volume>60</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>51-102</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Devriese]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On the Discovery of Clostridium botulinum]]></article-title>
<source><![CDATA[J Hist Neurosci]]></source>
<year>1999</year>
<volume>64</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>43-50</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rohrich]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Janis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fagien]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Botulinum toxin: Extended aplications in medicine]]></article-title>
<source><![CDATA[Plast Reconst Surg]]></source>
<year>2004</year>
<volume>114</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>6-42</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gassner]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of facial wounds whit wounds botulinum toxin A improves cosmetic outcome in primates]]></article-title>
<source><![CDATA[Plast Reconst Surg]]></source>
<year>2000</year>
<volume>105</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>92-144</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sherris]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Botox injections may improve facial. Wound healing, minimize scars]]></article-title>
<source><![CDATA[Mayo Clinics Proceedings]]></source>
<year>2005</year>
<volume>122</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>23-57</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coiffman]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Cirugía plástica reconstructiva y estética]]></source>
<year>2006</year>
<volume>1</volume>
<edition>3ra</edition>
<publisher-loc><![CDATA[Colombia ]]></publisher-loc>
<publisher-name><![CDATA[Amolca]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baker]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Colgajos locales en la reconstrucción facial]]></source>
<year>2010</year>
<volume>1</volume>
<edition>2da</edition>
<publisher-loc><![CDATA[Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[Amolca]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erbguth]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Neumann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Historical aspects of botulinum toxin: Justinus Kerner and the "sausagepoison"]]></article-title>
<source><![CDATA[Neurology]]></source>
<year>1999</year>
<volume>53</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1850-3</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carruthers]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[History of the clinical use of botulinum toxin A and B]]></article-title>
<source><![CDATA[Clin Dermatol]]></source>
<year>2003</year>
<volume>21</volume>
<page-range>469-72</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koussoulakos]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Botulinum neurotoxin: the ugly duckling]]></article-title>
<source><![CDATA[Eur Neurol]]></source>
<year>2009</year>
<volume>61</volume>
<page-range>331-42</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erbguth]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[From poison to remedy: the chequered history of botulinum toxin]]></article-title>
<source><![CDATA[J Neural Transm]]></source>
<year>2008</year>
<volume>115</volume>
<page-range>559-65</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
