<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922020000100014</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922020000100014</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Rol de la carboxiterapia en la mejora de la calidad de piel antes de ritidoplastia]]></article-title>
<article-title xml:lang="en"><![CDATA[Role of carboxitherapy in improving skin quality prior to rhythidoplasty]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorado]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cárdenas Camarena]]></surname>
<given-names><![CDATA[Lázaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[Hiram]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerrero]]></surname>
<given-names><![CDATA[María Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sander]]></surname>
<given-names><![CDATA[Matías]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Jalisciense de Cirugía Reconstructiva Dr. Guerrerosantos  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Innovare Cirugía Plástica  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Innovare Otorrinolaringología  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>46</volume>
<numero>1</numero>
<fpage>99</fpage>
<lpage>106</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922020000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922020000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922020000100014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y objetivo Los cambios anatómicos faciales que resultan como consecuencia del envejecimiento son uno de los principales motivos de consulta en Cirugía Estética facial. Nos proponemos determinar los cambios histológicos secundarios a la aplicación de carboxiterapia previa a la ritidoplastia, tomando en cuenta la aceptación de los pacientes en relación a mejora en la calidad de su piel facial tras el tratamiento.  Material y método Aplicamos 10 sesiones de carboxiterapia facial 5 semanas antes de la intervención quirúrgica de ritidoplastia. Infiltramos el dióxido de carbono por vía percutánea alrededor de cara y cuello a excepción de las regiones pre y postauriculares derechas. La ritidpolastia fue realizada por diferentes cirujanos y codificamos y analizamos las muestras de piel tomadas de las áreas pre y postauriculares  Resultados Llevamos a cabo el estudio en 7 pacientes. Histología: la disposición de las fibras de colágeno fue en espiral y nódulos en la zona preauricular derecha (área no tratada), mientras que en la zona preauricular izquierda la disposición de colágeno fue lineal, diferencia estadísticamente significativa (p=0.0052). La proliferación de tejido celular subcutáneo en la zona preauricular izquierda disminuyó de una manera evidente (p=0.03), mientras que el área postauricular no presentó este fenómeno (p=0.10).  Conclusiones La carboxiterapia previa a la cirugía de ritidoplastia es un procedimiento seguro, que en nuestro estudio no prolongó el tiempo quirúrgico ni aumentó la respuesta inflamatoria. Los cambios histológicos hallados demostraron cambios en la disposición del colágeno en las áreas tratadas, con mayor elasticidad de la piel. Hubo también disminución en la proliferación celular en el área que recibió carboxiterapia sin alteración de la estructura de la dermis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background and objective Anatomical facial changes as a result of aging are one of the main reasons for consultation in Facial Aesthetic Surgery. We propose to determine the histological changes secondary to the application of carboxytherapy prior to rithidoplasty, taking into account the acceptance of patients in relation to improvement in the quality of their facial skin after treatment.  Methods We applied 10 sessions of facial carboxytherapy 5 weeks before the surgical procedure of rhithidoplasty, infiltrating carbon dioxide percutaneously around the face and neck except for the right pre and post-auricular regions. Rhithidoplasty was performed by different surgeons and we encode and analyze the skin samples taken from the pre and post-auricular areas  Results The study was conducted on 7 patients. Histology: the arrangement of the collagen fibers was spiral and nodules in the right preauricular zone (untreated area), while in the left preauricular zone the collagen arrangement was linear, statistically significant difference (p=0.0052). Proliferation of subcutaneous cellular tissue in the left preauricular area decreased in an evident way (p=0.03), while the postauricular area did not present this phenomenon (p=0.10).  Conclusions Carboxitherapy prior to rhythidoplasty surgery is a safe procedure, that in our study did not prolong surgical time or increase the inflammatory response. The histological changes found showed variations in the arrangement of collagen in the treated areas, with greater elasticity of the skin. There was also a decrease in cell proliferation in the area that received carboxytherapy without altering the structure of the dermis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carboxiterapia]]></kwd>
<kwd lng="es"><![CDATA[Calidad piel]]></kwd>
<kwd lng="es"><![CDATA[Envejecimiento]]></kwd>
<kwd lng="es"><![CDATA[Ritidoplastia]]></kwd>
<kwd lng="en"><![CDATA[Carboxitherapy]]></kwd>
<kwd lng="en"><![CDATA[Skin quality]]></kwd>
<kwd lng="en"><![CDATA[Aging]]></kwd>
<kwd lng="en"><![CDATA[Rhithidoplasty]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="">
<collab>American Society of Plastic Surgeons</collab>
<source><![CDATA[Plastic surgery statistics reports]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coon]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plastic Surgery and Smoking: A Prospective Analysis of Incidence, Compliance, and Complications]]></article-title>
<source><![CDATA[Plast Reconstruct Surg]]></source>
<year>2013</year>
<volume>131</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>385-91</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Covarrubias]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the Histological Changes in the Fat Grafted Facial Skin: Clinical Trial]]></article-title>
<source><![CDATA[Aesth Plast Surg]]></source>
<year>2013</year>
<volume>37</volume>
<page-range>778-83</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Albergati]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Parassoni]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lattarulo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Varlaro]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Curri]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carbossiterapia e vasomotion: comparazione tra immagini video-capillaroscopiche e referti doppler laser flow dopo somministrazionedi anidride carbonica]]></article-title>
<source><![CDATA[Riv La Medicina Estetica]]></source>
<year>1997</year>
<volume>21</volume>
<numero>1</numero>
<issue>1</issue>
<publisher-loc><![CDATA[Roma ]]></publisher-loc>
<publisher-name><![CDATA[Editrice Salus Internazionale]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Belotti]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[De Bernardi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Utilizzazione della CO2 PEFS]]></article-title>
<source><![CDATA[Riv La Medicina Estetica]]></source>
<year>1992</year>
<volume>16</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<publisher-loc><![CDATA[Roma ]]></publisher-loc>
<publisher-name><![CDATA[Editrice Salus Internazionale]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kippenberger]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Loitsch]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Guschel]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mueller]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Knies]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kaufmann]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bernd]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II Type 1 receptor and epidermal growth factor receptor]]></article-title>
<source><![CDATA[J Biol Chem]]></source>
<year>2005</year>
<volume>280</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>3060-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kessler]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dethlefsen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Haase]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Plomann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hirsche]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Krieg]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Eckes]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype]]></article-title>
<source><![CDATA[J Biol Chem]]></source>
<year>2001</year>
<volume>276</volume>
<numero>39</numero>
<issue>39</issue>
<page-range>36575-85</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grinnell]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Carlson]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Abrams]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue]]></article-title>
<source><![CDATA[Exp Cell Res]]></source>
<year>1999</year>
<volume>248</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>608-19</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brandic]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[D'Aniello]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Grimaldi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bosi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Dei]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Lattarulo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Alessandrini]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carbon dioxide therapy in the treatment of localized adiposities clinical: study and histopathological correlations]]></article-title>
<source><![CDATA[Aesth Plast Surg]]></source>
<year>2001</year>
<volume>25</volume>
<page-range>170-4</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kippenberger]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Loitsch]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Mueller]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guschel]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[RamirezBosca]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kaufmann]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bernd]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Melanocytes respond to mechanical stretch by activation of mitogen-activated protein kinases (MAPK)]]></article-title>
<source><![CDATA[Pigment Cell Res]]></source>
<year>2000</year>
<volume>13</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>278-80</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[McGrath]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Navsaria]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of fibroblasts in tissue engineering and regeneration]]></article-title>
<source><![CDATA[Br J Dermatol]]></source>
<year>2007</year>
<volume>156</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1149-55</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[JCT]]></given-names>
</name>
<name>
<surname><![CDATA[Haddad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Tavares]]></surname>
<given-names><![CDATA[SAN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increase in collagen turnover induced by intradermal injection of carbon dioxide in rats]]></article-title>
<source><![CDATA[J Drugs Dermato]]></source>
<year>2008</year>
<volume>7</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>201-6</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[Kriazhev]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hernandez-Blazquez]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bateman]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis]]></article-title>
<source><![CDATA[Growth Factors]]></source>
<year>2007</year>
<page-range>280-5</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Swim]]></surname>
<given-names><![CDATA[HE]]></given-names>
</name>
<name>
<surname><![CDATA[Parker]]></surname>
<given-names><![CDATA[RF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of carbon dioxide as an essential nutrient for six permanent strains of fibroblasts]]></article-title>
<source><![CDATA[J Biophys Biochem Cytol]]></source>
<year>1958</year>
<volume>4</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>525-8</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="">
<collab>Helsinki Declaration of the WMA</collab>
<source><![CDATA[Ethical Principles for Medical Research Involving Human]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Thampatty]]></surname>
<given-names><![CDATA[BP]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Im]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanoregulation of gene expression in fibroblasts]]></article-title>
<source><![CDATA[Gene]]></source>
<year>2007</year>
<volume>391</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>1-15</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Varani]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Schuger]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Dame]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Leonard]]></surname>
<given-names><![CDATA[Ch]]></given-names>
</name>
<name>
<surname><![CDATA[Fligiel]]></surname>
<given-names><![CDATA[SEG]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fisher]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Voorhees]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin]]></article-title>
<source><![CDATA[J Invest Dermatol]]></source>
<year>2004</year>
<volume>122</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1471-9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
