<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922021000200010</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922021000200010</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Toxina botulinica tipo a en el tratamiento del queloide]]></article-title>
<article-title xml:lang="en"><![CDATA[Botulinic toxin type a in the treatment of keloid]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Higuerey Morao]]></surname>
<given-names><![CDATA[Deivys J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto Montenegro]]></surname>
<given-names><![CDATA[Andrés E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giorginaani Colmenares]]></surname>
<given-names><![CDATA[Giovanni S]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General del Este Dr. Domingo Luciani  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Vargas de Caracas  ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>47</volume>
<numero>2</numero>
<fpage>187</fpage>
<lpage>200</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922021000200010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922021000200010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922021000200010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y objetivo.  El proceso de cicatrización, cuando se ve perturbado o interrumpido, puede conllevar una reparación cutánea descontrolada como la observada en los queloides. Son reconocidos como tumores fibroproliferativos únicos en humanos, lesiones difíciles de tratar debido a que la mayoría de los enfoques terapéuticos siguen siendo clínicamente insatisfactorios. Sin embargo, estudios recientes sugieren que la toxina botulínica tipo A (TBA) influye en la apoptosis y proliferación celular, razón por lo cual nos planteamos demostrar si la TBA intralesional produce mejoría no solo clínica, sino también histológica en el queloide.  Material y método. Seleccionamos 11 queloides y realizamos biopsias de los mismos, además de medición previa y en 3 controles posteriores a la aplicaciónn de TBA. Hacemos descripción histopatológica de los cambios observados a los 3 meses mediante el Sofware Image Pro Plus, versión 5.0 (Olympus®) y tinciones con hematoxilina-eosina (H/E) y tricrómico de Masson. Aplicamos tratamiento estadístico mediante análisis de las características demográficas y clínicas. A las variables nominales se le determinaron frecuencia y porcentajes, por lo que elaboramos tablas descriptivas. Con las variables cuantitativas trabajamos con medidas de tendencia central (media). Para la comparación y el análisis de las variables utilizamos medidas de tendencia central (media), coeficiente de relación de Pearson y desviación estándar.  Resultados.  La edad promedio fue de 31 años, el sexo predominante fue el femenino (63%), la etiología más frecuente fue postraumática (35%), predominó el tipo de piel IV (50%), clínicamente hubo mejoría significativa de altura y anchura del queloide confirmada mediante coeficiente de relación de Pearson con un -0.91 y -0.88 respectivamente, así como del dolor, prurito, coloración y consistencia; también reducción del diámetro de la epidermis verificado por desviación estándar y cambios en la dermis en cuanto a distribución del colágeno, vascularización, infiltrado inflamatorio y unión dermoepidermica se refiere.  Conclusiones. Dados los resultados obtenidos en nuestro estudio desde el punto de vista clínico e histopatológico, planteamos la TBA como una nueva opción terapéutica para el tratamiento del queloide.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background and objective.  When the healing process is disturbed or interrupted, uncontrolled skin repair can occur, such as that observed in keloid. These are recognized as unique fibroproliferative tumors in humans, always representing difficult-to-treat lesions because most therapeutic approaches remain clinically unsatisfactory. However, recent studies have suggested that botulinum toxin type A (BTA) influences apoptosis and cell proliferation. This is why we set out to demonstrate whether intralesional BTA produces improvement not only clinically but also histologically in the keloid.  Methods.  Eleven keloids were selected and biopsies were performed as well as previous measurements and 3 controls after the application of BTA. Histopathological description of the changes observed 3 months after therapy using the Software Image Pro Plus, version 5.0 (Olympus®) and stains with hematoxylin-eosin (H/E) and Masson's trichomic. Statistical treatment was applied through analysis of demographic and clinical characteristics. The frequency and percentages were determined for the nominal variables, so descriptive tables were made. With the quantitative variables we worked with measures of central tendency (average). For the comparison and analysis of the variables, measures of central tendency (mean), coefficient of Pearson relation and standard deviation were used.  Results. The average age was 31 years, the predominant sex was female (63%), the most frequent etiology was posttraumatic (35%), the skin type IV predominated (50%). Clinically there was significant improvement in height and width of the keloid confirmed by Pearson's coefficient of relationship with -0.91 and -0.88 respectively and improvement of pain, pruritus, coloration and consistency, as well as reduction of the diameter of the epidermis verified by standard deviation and changes on the dermis in terms of collagen distribution, vascularization, inflammatory infiltrate and dermo-epidermal junction.  Conclusions.  Due to the results obtained in our study from the clinical and histopathological point of view, BTA could be considered as a new therapeutic option for the treatment of keloid.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Queloide]]></kwd>
<kwd lng="es"><![CDATA[Colágeno hialinizado]]></kwd>
<kwd lng="es"><![CDATA[Toxina botulínica tipo A]]></kwd>
<kwd lng="en"><![CDATA[Keloid]]></kwd>
<kwd lng="en"><![CDATA[Hyalinized collagen]]></kwd>
<kwd lng="en"><![CDATA[Botulinum toxin type A]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bran]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Goessler]]></surname>
<given-names><![CDATA[UR]]></given-names>
</name>
<name>
<surname><![CDATA[Hormann]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Riedel]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sadick]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Keloids: current concepts of pathogenesis]]></article-title>
<source><![CDATA[Int J Mol Med]]></source>
<year>2009</year>
<volume>24</volume>
<page-range>283-93</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jumper]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Paus]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bayat]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Functional histopathology of keloid disease]]></article-title>
<source><![CDATA[Histol Histopathol]]></source>
<year>2015</year>
<volume>30</volume>
<page-range>1033-57</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Juckett]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hartman-Adams]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of keloids and hypertrophic scars]]></article-title>
<source><![CDATA[Am Fam Physician]]></source>
<year>2009</year>
<volume>80</volume>
<page-range>253-60</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Akaishi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hyakusoku]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Ogawa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Are keloid and hypertrophic scar different forms of the same disorder: A fibroproliferative skin disorder hypothesis based on keloid findings]]></article-title>
<source><![CDATA[Int Wound J]]></source>
<year>2014</year>
<volume>11</volume>
<page-range>517-22</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hahn]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Glaser]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[McFarland]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Aronow]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Boyce]]></surname>
<given-names><![CDATA[ST]]></given-names>
</name>
<name>
<surname><![CDATA[Supp]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology]]></article-title>
<source><![CDATA[Wound Repair Regen]]></source>
<year>2013</year>
<volume>21</volume>
<page-range>530-44</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mari]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Alsabri]]></surname>
<given-names><![CDATA[SG]]></given-names>
</name>
<name>
<surname><![CDATA[Tabal]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Younes]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sherif]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Simman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel insights on understanding of keloid scar: article review]]></article-title>
<source><![CDATA[J Am Coll Clin Wound Spec]]></source>
<year>2016</year>
<volume>7</volume>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trace]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Enos]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
<name>
<surname><![CDATA[Mantel]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Harvey]]></surname>
<given-names><![CDATA[VM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Keloids and hypertrophic scars: A spectrum of clinical challenges]]></article-title>
<source><![CDATA[Am J Clin Dermatol]]></source>
<year>2016</year>
<volume>17</volume>
<page-range>201-23</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jumper]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Hodgkinson]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Paus]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bayat]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology]]></article-title>
<source><![CDATA[Plos One]]></source>
<year>2017</year>
<volume>12</volume>
<page-range>1-33</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hahn]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Glaser]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[McFarland]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Combs]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Supp]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-ß1]]></article-title>
<source><![CDATA[Burns Trauma]]></source>
<year>2016</year>
<volume>4</volume>
<page-range>30-47</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Limandjaja]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[van den Broek]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Waaijman]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[van Veen]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Everts]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Monstrey]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Scheper]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increased epidermal thickness and abnormal epidermal differentiation in keloid scars]]></article-title>
<source><![CDATA[Br J Dermatol]]></source>
<year>2017</year>
<volume>176</volume>
<page-range>116-26</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Xia]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Growth differentiationfactor-9 promotes fibroblast proliferation and migration in keloids through the Smad2/3 pathway]]></article-title>
<source><![CDATA[Cell Physiol Biochem]]></source>
<year>2016</year>
<volume>40</volume>
<page-range>207-18</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amadeu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Braune]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mandarim-de-Lacerda]]></surname>
</name>
<name>
<surname><![CDATA[Porto]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Desmouliere]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vascularization pattern in hypertrophic scars and keloids: A stereological analysis]]></article-title>
<source><![CDATA[Patrol Res Pract]]></source>
<year>2003</year>
<volume>199</volume>
<page-range>469-73</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quintero-Larróvere]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Flores-Sánchez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Soto-Montenegro]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efectos de la relajación muscular perilesional con toxina botulínica Tipo A en la cicatrización de heridas faciales postraumáticas]]></article-title>
<source><![CDATA[Cir. plást. iberolatinoam.]]></source>
<year>2018</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>203-15</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldring]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
<name>
<surname><![CDATA[Thiagarajah]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Watt]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect on the differentiation of fibroblast and myoblast, in vitro]]></article-title>
<source><![CDATA[J Cell Sci]]></source>
<year>2002</year>
<volume>115</volume>
<page-range>355-66</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dvorankova]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Szabo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Lacina]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Gal]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Uhrova]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zima]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<collab>kaltner H</collab>
<article-title xml:lang=""><![CDATA[Human galentins induce conversion of dermal fibroblasts into myofibroblast and production of extracellular matrix: Potential application in tissue engineering and wound repair]]></article-title>
<source><![CDATA[Cells Tissues Organs]]></source>
<year>2011</year>
<volume>194</volume>
<page-range>469-80</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Elola]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Blidner]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Ferragut]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bracalente]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Rabinovich]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assembly, organization and regulation of cell-surface receptors by lectin-glycan complex]]></article-title>
<source><![CDATA[Biochem J]]></source>
<year>2015</year>
<volume>469</volume>
<page-range>1-16</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lacina]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Plzaková]]></surname>
</name>
<name>
<surname><![CDATA[Smetana Jr]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Stork]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kaltner]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Glycophenotype of psoriatic skin]]></article-title>
<source><![CDATA[Folia Biologica (Praha)]]></source>
<year>2006</year>
<volume>52</volume>
<page-range>10-5</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marcos-Garcés]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Molina]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Bea]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Benavent]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrández]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz-Sauri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Age-related dermal collagen changes during development, maturation and ageing-a morphometric and comparative study]]></article-title>
<source><![CDATA[J Anat]]></source>
<year>2014</year>
<volume>225</volume>
<page-range>98-108</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robinson]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Khadim]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Keloid scars and treatment with botulinum toxin type A: the Belfast experience]]></article-title>
<source><![CDATA[J Plast Reconstr Aesthet Surg]]></source>
<year>2013</year>
<volume>66</volume>
<page-range>439-40</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gassner]]></surname>
<given-names><![CDATA[HG]]></given-names>
</name>
<name>
<surname><![CDATA[Brissett]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<name>
<surname><![CDATA[Otley]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Boahene]]></surname>
<given-names><![CDATA[DK]]></given-names>
</name>
<name>
<surname><![CDATA[Boggust]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Weaver]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Botulinum toxin to improve facial wound healing: a prospective, blinded, placebo-controlled study]]></article-title>
<source><![CDATA[Mayo Clin Proc]]></source>
<year>2006</year>
<volume>81</volume>
<page-range>1023-8</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhibo]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Miaobo]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Botulinum toxin type A affects cell cycle distribution of fibroblasts derived from hypertrophic scar]]></article-title>
<source><![CDATA[J Plast Reconstr Aesthet Surg]]></source>
<year>2008</year>
<volume>61</volume>
<page-range>1128-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhibo]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Miaobo]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intralesional botulinum toxin type A injection as a new treatment measure for keloids]]></article-title>
<source><![CDATA[Plast Reconstr Surg]]></source>
<year>2009</year>
<volume>124</volume>
<page-range>275e-7e</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gauglitz]]></surname>
<given-names><![CDATA[GG]]></given-names>
</name>
<name>
<surname><![CDATA[Bureik]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dombrowski]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Pavicic]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Botulinum toxin A for the treatment of keloids]]></article-title>
<source><![CDATA[Skin Pharmacol Physiol]]></source>
<year>2012</year>
<volume>25</volume>
<page-range>313-8</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uso de toxina botulínica en cicatriz queloide]]></article-title>
<source><![CDATA[Asociación Mexicana de Cirugía General, Cir Gen]]></source>
<year>2014</year>
<volume>36</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>76-81</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of hypertrophic scars with intralesional botulinum toxin type A injections: a preliminary report]]></article-title>
<source><![CDATA[Aesthetic Plast Surg]]></source>
<year>2009</year>
<volume>33</volume>
<page-range>409-12</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
