<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922021000400389</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922021000400009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores de riesgo en pacientes con fisura de labio y paladar en México. Estudio en 209 pacientes]]></article-title>
<article-title xml:lang="en"><![CDATA[Risk factors associated with cleft lip and palate in Mexico. A 209 patient analysis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-González]]></surname>
<given-names><![CDATA[Araceli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lavielle-Sotomayor]]></surname>
<given-names><![CDATA[Pilar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tusie-Luna]]></surname>
<given-names><![CDATA[María Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palafox]]></surname>
<given-names><![CDATA[Damián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Mexicana para Niños con Labio y Paladar Hendido AC  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social (IMSS) Departamento de Epidemiología Clínica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Infantil de México "Federico Gómez" Servicio de Epidemiología Clínica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" (INCMNSZ) Unidad de Medicina Genómica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Ángeles Puebla Departamento de Cirugía Plástica y Reconstructiva ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>47</volume>
<numero>4</numero>
<fpage>389</fpage>
<lpage>394</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922021000400389&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922021000400389&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922021000400389&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y objetivo. El labio hendido (con o sin paladar hendido asociado) y el paladar hendido aislado afectan a 1 de cada 600 recién nacidos en el mundo. Su etiología es multifactorial e intervienen factores de medioambiente, sociodemográficos y genéticos. El objetivo del presente estudio es establecer una relación entre los distintos tipos de fisuras labio-palatinas y diversos factores de riesgo asociados a su prevalencia en México.  Material y método. Estudiamos 209 pacientes de diferentes edades con diagnóstico de labio y paladar hendido, atendidos en hospitales generales públicos y privados de las regiones del norte, centro y sur de la república mexicana. Obtuvimos los datos de los pacientes a través de entrevistas a madres o tutores en los menores de edad y por entrevista directa a los mayores de edad.  Resultados. El 47.8% fueron mujeres. La edad promedio fue de 8.9 ± 7.3 años. Del total, 163 (78%) tenían diagnóstico de fisura labio-palatina, y 46 (22%) de fisura de labio o paladar aislados. La edad de la madre al momento del embarazo infuyó en la mayor prevalencia de la fisura labio-palatina. Los antecedentes familiares de fisuras labio-palatinas también determinaron mayor porcentaje de pacientes con labio + paladar hendido que con el padecimiento aislado (41.1% frente a 26.1% respectivamente).  Conclusiones. Consideramos que, dado que la edad de la madre al momento del embarazo es un factor directamente asociado a la prevalencia de la fisura labio-palatina, los estudios derivados de Salud Pública son fundamentales, particularmente aquellos que tratan sobre el embarazo de alto riesgo (madre adolescente y madre de edad avanzada).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background and objective. Cleft lip and palate are associated with several factors including demographic and genetic factors among others. The estimated prevalence of the disease is 1-600 worldwide. Our aim is to study the relationship between the prevalence of cleft lip and palate and several factors associated to the disease in Mexico.  Methods. A total of 209 patients with cleft lip and palate (isolated or combined) were included. Patients were referred from both public and private hospitals. Data were collected through direct interview and questionnaire with patientes´ mother or parent.  Results. In our study, 47.8% patients were female. Mean age was 8.9 ± 7.3 years old; 163 patients (78%) had a combined cleft-lip and palate, and 46 (22%) had an isolated cleft lip or palate. Mother´s age was directly associated with the prevalence of cleft lip and palate. The history of facial clefts in the family was also directly related to the presence of a combined cleft, in contrast to an isolated cleft. (41.1% vs 26.1% respectively).  Conclusions. In our study, both cleft lip and palate were directly related to the age of the mother. Thus, we believe that future studies should address the importance of preventive measures and treatment in the woman with a high-risk pregnancy (such as adolescent teens with pregnancy and elderly women).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Labio hendido]]></kwd>
<kwd lng="es"><![CDATA[Paladar hendido]]></kwd>
<kwd lng="es"><![CDATA[Fisuras labio-palatinas]]></kwd>
<kwd lng="en"><![CDATA[Clef lip]]></kwd>
<kwd lng="en"><![CDATA[Clef palate]]></kwd>
<kwd lng="en"><![CDATA[Clef lip-palate]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nieuwenhuijsen]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Dadvan]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Grellier]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Vrijheid]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies]]></article-title>
<source><![CDATA[Environ Health]]></source>
<year>2013</year>
<volume>15</volume>
<page-range>12-6</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wallenstein]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Carmichael]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Periconceptional nutrient intakes and risks of orofacial clefts in California]]></article-title>
<source><![CDATA[Pediatr Res]]></source>
<year>2013</year>
<volume>74</volume>
<page-range>457-65</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Little]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cardy]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Munger]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tobacco smoking and oral clefts: a meta-analysis]]></article-title>
<source><![CDATA[Bull World Health Organ]]></source>
<year>2004</year>
<volume>82</volume>
<page-range>213-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dex Roo]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Wilcox]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lie]]></surname>
<given-names><![CDATA[RT]]></given-names>
</name>
<name>
<surname><![CDATA[Romitti]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Pedersen]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Munger]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maternal alcohol binge-drinking in the frst trimester and the risk of orofacial clefts in offspring: a large population-based pooling study]]></article-title>
<source><![CDATA[Eur J Epidemiol]]></source>
<year>2016</year>
<volume>31</volume>
<page-range>1021-34</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Impellizzeri]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Giannantoni]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Polimeni]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Barbato]]></surname>
<given-names><![CDATA[Galluccio]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiological characteristic of Orofacial clefts and its associated congenital anomalies: retrospective study]]></article-title>
<source><![CDATA[BMC Oral Health]]></source>
<year>2019</year>
<volume>19</volume>
<page-range>290</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
<name>
<surname><![CDATA[Wanessa]]></surname>
<given-names><![CDATA[da Cruz K]]></given-names>
</name>
<name>
<surname><![CDATA[Monteiro]]></surname>
<given-names><![CDATA[de Barros L]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Martelli]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maternal and paternal age, birth order and interpregnancy interval evaluation for cleft lip palate]]></article-title>
<source><![CDATA[Braz J Otorhinolaryngol]]></source>
<year>2010</year>
<volume>76</volume>
<page-range>107-12</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[HPVD]]></given-names>
</name>
<name>
<surname><![CDATA[Arruda]]></surname>
<given-names><![CDATA[TTS]]></given-names>
</name>
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[KSC]]></given-names>
</name>
<name>
<surname><![CDATA[Bezerra]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Leite]]></surname>
<given-names><![CDATA[GCP]]></given-names>
</name>
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[MEF]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[VMGDM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk factors and comorbidities in Brazilian patients with orofacial clefts]]></article-title>
<source><![CDATA[Braz Oral Res]]></source>
<year>2018</year>
<volume>32</volume>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[UL]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[XH]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[SQ]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maternal age, parity and isolated birth defects: a population-based case-control study in Shenzhen, China]]></article-title>
<source><![CDATA[PLoS One]]></source>
<year>2013</year>
<volume>25, 8</volume>
<numero>11</numero>
<issue>11</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsuchiya]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tsuchiya]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Momma]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Koseki]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Igarashi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Nagatomi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of Cleft Lip and Palate on Mother-To-Infant Bonding: A Cross-Sectional Study in the Japan Environment and Children&#8217;s Study (JECS)]]></article-title>
<source><![CDATA[BMC Pediatr]]></source>
<year>2019</year>
<volume>20</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>505</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palomino]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Guzmán]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Blanco]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Familial recurrence of non syndromic cleft lip with or without cleft palate in Chilean populations]]></article-title>
<source><![CDATA[Rev Med Chil]]></source>
<year>2000</year>
<volume>128</volume>
<page-range>286-93</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zheng]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zeng]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Du]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors]]></article-title>
<source><![CDATA[BMC Pregnancy Childbirth]]></source>
<year>2016</year>
<volume>23</volume>
<page-range>368</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raut]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Simeone]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Tinker]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Canfeld]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Day]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Agopian]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proportion of orofacial clefts attributable to recognized risk factors]]></article-title>
<source><![CDATA[Cleft Palate Craniofac J]]></source>
<year>2019</year>
<volume>56</volume>
<page-range>151-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sigler]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Protocolo para la planificación quirúrgica en las clínicas de labio y paladar hendidos en la zona noroeste de la República Mexicana]]></article-title>
<source><![CDATA[Cir. plást. iberolatinoam]]></source>
<year>2017</year>
<volume>43</volume>
<page-range>313-25</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zambrana-Rojas]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Vallarta-Rodríguez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Duarte-Sánchez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Labor de proyección humanitaria de la FILACP. Campaña 2019]]></article-title>
<source><![CDATA[Cir. plást. iberolatinoam]]></source>
<year>2019</year>
<volume>45</volume>
<page-range>449-56</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
