<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922022000300006</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922022000300006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad por inyección de rellenos sintéticos permanentes (EIRSP). Recomendaciones del grupo de expertos del Capítulo de Biomateriales de la FILACP]]></article-title>
<article-title xml:lang="en"><![CDATA[Disease caused by permanent synthetic fillers FILACP Biomaterials Committee expert group recomendations]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveros]]></surname>
<given-names><![CDATA[César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Rivera]]></surname>
<given-names><![CDATA[Fabián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betti-Kraemer]]></surname>
<given-names><![CDATA[Giovanni]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cordero-de Oliveros]]></surname>
<given-names><![CDATA[María Daniela]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Romero]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medrano-Ramírez]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Schenone]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Slobodianik-Correa]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Bermúdez]]></surname>
<given-names><![CDATA[Joselit]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Federación Ibero Latinoamericana de Cirugía Plástica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Federación Ibero Latinoamericana de Cirugía Plástica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brasil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>48</volume>
<numero>3</numero>
<fpage>287</fpage>
<lpage>304</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922022000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922022000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922022000300006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La enfermedad por rellenos sintéticos permanentes (EIRSP) representa un verdadero problema de salud pública sobre todo en América Latina, afectando a millones de personas, predominantemente mujeres de mediana edad de estrato económico medio-bajo. Actualmente no existe una conducta terapéutica consensuada, razón que motivó al Comité de Biomateriales de la FILACP 2020-2022 a crear un grupo de 9 expertos quienes se plantearon los siguientes objetivos: 1.- Resaltar la importancia de la enfermedad, 2.- Clasificar sus estadios clínicos, 3.- Proponer un protocolo integral de diagnóstico y tratamiento, 4.- Proponer una estrategia terapéutica multidisciplinaria y 5.- Promover campañas de prevención. El relleno sintético más utilizado con fines estéticos ha sido la silicona inyectada en cara, glúteos, mamas, miembros inferiores, manos y genitales, con alto potencial de migración. Otras substancias son el metacrilato, aceites minerales, parafina y la combinación de ellas. Ninguno de estos productos es de grado médico ni biocompatible. Al ser inyectados van a producir diversas reacciones locales y sistémicas desencadenadas por reacción de hipersensibilidad tipo IV, conduciendo al desarrollo de una enfermedad autoinmune de tejido conectivo. Se propone una clasificación basada en 6 estadios clínicos o grados. 1: Sin signos ni síntomas. 2: Cambios de coloración. 3: Inflamación, induraciones, cambios de textura y dolor. 4: Extrusión del producto con o sin infección. 5: Migración. 6: Complicaciones locales o sistémicas graves. Se establecen las pautas diagnósticas basadas en la historia clínica, exámenes de laboratorio, inmunológicos y radiológicos. Para este último, la resonancia magnética es la técnica de elección y en algunos casos, con excepción de glúteos y mamas, el ultrasonido es de gran utilidad. Se plantean medidas de cuidados y pautas terapéuticas dependiendo del grado clínico según la clasificación propuesta en pacientes afectados por rellenos sintéticos que comprometen las regiones glúteas, lumbosacra, facial, genital, mamaria, ganglios axilares e inguinales y miembros inferiores.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Disease caused by permanent synthetic fillers (EIRSP acronym in Spanish) represents a real public health problem, especially in Latin America, affecting millions of people, predominantly middle-aged women from a medium-low economic stratum. Currently, there is no consensual therapeutic behavior, the reason that motivated the FILACP Biomaterials Committee 2020-2022 to create a group of 9 experts, who set the following objectives: 1.- Highlight the importance of the disease, 2.- Classify the clinical stages, 3.- Propose a comprehensive diagnosis and treatment protocol, 4.- Propose a multidisciplinary therapeutic strategy and 5.- Promote prevention campaigns. The most widely used synthetic filler for aesthetic purposes has been silicone injected into the face, buttocks, breasts, lower limbs, hands and genitals, with a high potential for migration. Other substances are methacrylate, mineral oils, paraffin, and a combination. None of these products have a medical grade or are biocompatible. When injected, they will produce various local and systemic reactions triggered by type IV hypersensitivity reactions, leading to the development of autoimmune connective tissue disease. A classification based on 6 clinical stages or grades is proposed. 1: No signs or symptoms. 2: Color changes. 3: Inflammation, indurations, texture changes, and pain. 4: Extrusion of the product with or without infection. 5: Migration. 6: Severe local or systemic complications. Diagnostic guidelines are established based on clinical history, laboratory, immunological and radiological tests. For the latter, magnetic resonance imaging is the technique of choice, and in some cases, except for the buttocks and breasts, ultrasound is beneficial. Care measures and therapeutic guidelines are proposed depending on the clinical grade according to the proposed classification in patients affected by synthetic fillers that compromise the gluteal, lumbosacral, facial, genital, mammary regions, axillary and inguinal nodes and lower limbs.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biopolímeros]]></kwd>
<kwd lng="es"><![CDATA[Rellenos permanentes]]></kwd>
<kwd lng="es"><![CDATA[inyección silicona]]></kwd>
<kwd lng="es"><![CDATA[Polimetilmetacrilato]]></kwd>
<kwd lng="es"><![CDATA[Síndrome ASIA.]]></kwd>
<kwd lng="en"><![CDATA[Biopolymers]]></kwd>
<kwd lng="en"><![CDATA[Permanent fillers]]></kwd>
<kwd lng="en"><![CDATA[Silicone injection]]></kwd>
<kwd lng="en"><![CDATA[Polymethyl-methacrylate]]></kwd>
<kwd lng="en"><![CDATA[ASIA Syndrome]]></kwd>
</kwd-group>
</article-meta>
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<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zandi]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Failure to remove soft tissue injected with liquid silicone with use of suction and honesty in scientific medical reports]]></article-title>
<source><![CDATA[Plast Reconstr Surg]]></source>
<year>2000</year>
<volume>76</volume>
<page-range>1555-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
