<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922022000400003</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922022000400003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto del uso de secretoma de células madre mesenquimales sobre heridas cutáneas. Análisis comparativo in vitro e in vivo de tres tipos de secretoma]]></article-title>
<article-title xml:lang="en"><![CDATA[Effects of mesenchymal stem cell secretome on skin wounds. In vitro and in vivo comparative analysis of three types of secretome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cases-Perera]]></surname>
<given-names><![CDATA[Oriol]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blanco-Elices]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Piedra]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alaminos]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garzón]]></surname>
<given-names><![CDATA[Ingrid]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Virgen de las Nieves Servicio de Cirugía Plástica ]]></institution>
<addr-line><![CDATA[Granada ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Granada Facultad de Medicina Departamento de Histología (Grupo de Ingeniería Tisular)]]></institution>
<addr-line><![CDATA[Granada ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>48</volume>
<numero>4</numero>
<fpage>367</fpage>
<lpage>376</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922022000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922022000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922022000400003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y objetivo. Los avances en el campo de la Ingeniería Tisular han promovido el desarrollo de sustitutos de piel y su aplicación en el campo de la Cirugía Plástica. Uno de los principales inconvenientes de la bioingeniería de la piel es la necesidad de obtener una gran cantidad de células viables en periodos cortos de tiempo, lo que conlleva que el proceso de biofabricación sea largo y complejo. En este estudio se pretende valorar los efectos de la aplicación de tres tipos diferentes de secretoma derivados de células madre mesenquimales humanas en cultivos de fibroblastos con el objetivo de favorecer la escalabilidad de los procesos de fabricación de piel artificial.  Material y método. Se evaluaron los efectos a las 24, 48 y 72 horas sobre la viabilidad, la proliferación y la migración celular de fibroblastos humanos tras la aplicación de dos concentraciones (C1 y C2) de tres tipos diferentes de secretoma derivado de células madre mesenquimales humanas. Los resultados in vitro fueron contrastados en un modelo in vivo.  Resultados. El uso de secretoma derivado de células madre mesenquimales mejoró los protocolos de cultivo de fibroblastos actualmente disponibles. El uso de secretoma se asoció a un aumento de la proliferación y migración celular manteniendo cifras altas de viabilidad. Los datos fueron especialmente positivos para el secretoma de células madre mesenquimales de pulpa dental y de tejido adiposo.  Conclusiones. El efecto de la aplicación de secretoma procedentes de células madre mesenquimales permite mantener cifras de viabilidad celular elevadas, además de incrementar el ritmo de proliferación de fibroblastos. Los estudios in vivo e in vitro no evidenciaron efectos adversos a corto plazo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background and objective. Advances in Tissue Engineering promoted the development of skin substitutes. One of the main drawbacks of skin bioengineering is the requirement of a considerable quantity of viable cells in short periods of time, which leads to a challenging biofabrication process. This article aims to analyse the effects of the application of three different types of human mesenchymal stem cell-derived secretome in fibroblast cultures. The final goal is to achieve new strategies to promote the scalability of artificial skin manufacturing processes.  Methods. The effects of the three different types of human mesenchymal stem cell-derived secretome were analyzed at 24, 48 and 72 hours. To study cell viability, cell proliferation and cell migration we exposed human fibroblasts to different secretome concentrations (C1 and C2). An in vivo study was proposed to corroborate in vitro results.  Results. The use of mesenchymal stem cell-derived secretome improved the currently available fibroblast culture protocols. The use of secretome was associated with increased cell proliferation and cell migration while maintaining high viability values. Data were especially positive when secretome from dental pulp mesenchymal stem cells and adipose tissue mesenchymal stem cells were applied.  Conclusions. The application of mesenchymal stem cell-derived secretome maintained high cell viability data and increased fibroblast proliferation. In vivo and in vitro studies showed no short-term adverse effects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fibroblastos]]></kwd>
<kwd lng="es"><![CDATA[Células madre mesenquimales]]></kwd>
<kwd lng="es"><![CDATA[Secretoma]]></kwd>
<kwd lng="es"><![CDATA[Ingeniería Tisular]]></kwd>
<kwd lng="es"><![CDATA[Piel artificial]]></kwd>
<kwd lng="en"><![CDATA[Fibroblasts]]></kwd>
<kwd lng="en"><![CDATA[Mesenchymal stem cell]]></kwd>
<kwd lng="en"><![CDATA[Secretome]]></kwd>
<kwd lng="en"><![CDATA[Tissue Engineering]]></kwd>
<kwd lng="en"><![CDATA[Artificial skin]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khavkin]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Ellis]]></surname>
<given-names><![CDATA[D.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aging skin: histology, physiology, and pathology]]></article-title>
<source><![CDATA[Facial Plast Surg Clin North Am]]></source>
<year>2011</year>
<volume>19</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>229-34</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of micronutrients in skin health and function]]></article-title>
<source><![CDATA[Biomol Ther (Seoul)]]></source>
<year>2015</year>
<volume>23</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>207-17</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanitakis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anatomy, histology and immunohistochemistry of normal human skin]]></article-title>
<source><![CDATA[Eur J Dermatol]]></source>
<year>2002</year>
<volume>12</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>390-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mesa]]></surname>
<given-names><![CDATA[K.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation]]></article-title>
<source><![CDATA[Cell Stem Cell]]></source>
<year>2018</year>
<volume>23</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>677.e4-86.e4</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[White]]></surname>
<given-names><![CDATA[S.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Yager]]></surname>
<given-names><![CDATA[J.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resident Dendritic Cells in the Epidermis: Langerhans Cells, Merkel Cells and Melanocytes]]></article-title>
<source><![CDATA[Vet Dermatol]]></source>
<year>1995</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scheuplein]]></surname>
<given-names><![CDATA[R.J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Properties of the skin as a membrane]]></article-title>
<source><![CDATA[Adv Biol Skin]]></source>
<year>1972</year>
<volume>12</volume>
<page-range>125-52</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thulabandu]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Atit]]></surname>
<given-names><![CDATA[R.P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dermal fibroblast in cutaneous development and healing]]></article-title>
<source><![CDATA[Wiley Interdiscip Rev Dev Biol]]></source>
<year>2018</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kruglikov]]></surname>
<given-names><![CDATA[I.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Scherer]]></surname>
<given-names><![CDATA[P.E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dermal Adipocytes: From Irrelevance to Metabolic Targets?]]></article-title>
<source><![CDATA[Trends Endocrinol Metab]]></source>
<year>2016</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carriel]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epithelial and stromal developmental patterns in a novel substitute of the human skin generated with fibrin-agarose biomaterials]]></article-title>
<source><![CDATA[Cells Tissues Organs]]></source>
<year>2012</year>
<volume>196</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[F.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Salgado]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mesenchymal stem cells secretome: current trends and future challenges]]></article-title>
<source><![CDATA[Neural Regen Res]]></source>
<year>2020</year>
<volume>15</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>75-7</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vizoso]]></surname>
<given-names><![CDATA[F.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2017</year>
<volume>18</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yannas]]></surname>
<given-names><![CDATA[I.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Burke]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design of an artificial skin. I. Basic design principles]]></article-title>
<source><![CDATA[J Biomed Mater Res]]></source>
<year>1980</year>
<volume>14</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>65-81</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mao]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Study of novel chitosan-gelatin artificial skin in vitro]]></article-title>
<source><![CDATA[J Biomed Mater Res A]]></source>
<year>2003</year>
<volume>64</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>301-8</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Matsuda]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A bilayer &#8220;artificial skin&#8221; capable of sustained release of an antibiotic]]></article-title>
<source><![CDATA[Br J Plast Surg]]></source>
<year>1991</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>142-6</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ladhani]]></surname>
<given-names><![CDATA[H.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Yowler]]></surname>
<given-names><![CDATA[C.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Claridge]]></surname>
<given-names><![CDATA[J.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Burn Wound Colonization, Infection, and Sepsis]]></article-title>
<source><![CDATA[Surg Infect (Larchmt)]]></source>
<year>2021</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>44-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lachiewicz]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bacterial Infections After Burn Injuries: Impact of Multidrug Resistance]]></article-title>
<source><![CDATA[Clin Infect Dis]]></source>
<year>2017</year>
<volume>65</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2130-6</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arrell]]></surname>
<given-names><![CDATA[D.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome]]></article-title>
<source><![CDATA[Stem Cells Transl Med]]></source>
<year>2021</year>
<volume>10</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1320-8</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsuji]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Kitamura]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Wada]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity]]></article-title>
<source><![CDATA[Stem Cells Int]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muhammad]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Nordin]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Fakurazi]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regenerative potential of secretome from dental stem cells: a systematic review of preclinical studies]]></article-title>
<source><![CDATA[Rev Neurosci]]></source>
<year>2018</year>
<volume>29</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>321-32</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Radek]]></surname>
<given-names><![CDATA[K.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing]]></article-title>
<source><![CDATA[J Appl Physiol (1985)]]></source>
<year>2008</year>
<volume>104</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1295-303</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gail]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Boone]]></surname>
<given-names><![CDATA[C.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Thompson]]></surname>
<given-names><![CDATA[C.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A calcium requirement for fibroblast motility and prolifertion]]></article-title>
<source><![CDATA[Exp Cell Res]]></source>
<year>1973</year>
<volume>79</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>386-90</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Praveen Kumar]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine]]></article-title>
<source><![CDATA[Cytokine Growth Factor Rev]]></source>
<year>2019</year>
<volume>46</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zimmerlin]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mesenchymal stem cell secretome and regenerative therapy after cancer]]></article-title>
<source><![CDATA[Biochimie]]></source>
<year>2013</year>
<volume>95</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2235-45</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gonzalez Suarez]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[EGCG Inhibits Adipose-Derived Mesenchymal Stem Cells Differentiation into Adipocytes and Prevents a STAT3-Mediated Paracrine Oncogenic Control of Triple-Negative Breast Cancer Cell Invasive Phenotype]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2021</year>
<volume>26</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hendijani]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Javanmard]]></surname>
<given-names><![CDATA[S.H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dual Protective and Cytotoxic Benefits of Mesenchymal Stem Cell Therapy in Combination with Chemotherapy/Radiotherapy for Cancer Patients]]></article-title>
<source><![CDATA[Crit Rev Eukaryot Gene Expr]]></source>
<year>2015</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>203-7</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Rinkevich]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Scars or Regeneration?-Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2020</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling]]></article-title>
<source><![CDATA[Burns]]></source>
<year>2018</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>370-85</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ajit]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ambika Gopalankutty]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adipose-derived stem cell secretome as a cell-free product for cutaneous wound healing]]></article-title>
<source><![CDATA[3 Biotech]]></source>
<year>2021</year>
<volume>11</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vackovca]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Kubinova]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stem cell conditioned medium for cell-free therapies]]></article-title>
<source><![CDATA[Cesk Fysiol]]></source>
<year>2016</year>
<volume>65</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-31</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
