<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0376-7892</journal-id>
<journal-title><![CDATA[Cirugía Plástica Ibero-Latinoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. plást. iberolatinoam.]]></abbrev-journal-title>
<issn>0376-7892</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0376-78922025000200211</article-id>
<article-id pub-id-type="doi">10.4321/s0376-78922025000200013</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reconstrucción de tejidos blandos en Síndrome de Nicolau: a propósito de un caso y revisión de la literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Soft tissue reconstruction in Nicolau Syndrome: a case and review of the literature]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte]]></surname>
<given-names><![CDATA[Juan Pablo Zaraza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ballesteros]]></surname>
<given-names><![CDATA[Paula X. Cardona]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez]]></surname>
<given-names><![CDATA[Frank A. Álvarez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[Nicol D. Cala]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mantilla]]></surname>
<given-names><![CDATA[Iván R. Rodríguez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallardo]]></surname>
<given-names><![CDATA[Luz E. Rueda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Rosario  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Clínica Los Nogales Bogotá]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>51</volume>
<numero>2</numero>
<fpage>211</fpage>
<lpage>216</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0376-78922025000200211&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0376-78922025000200211&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0376-78922025000200211&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El Síndrome de Nicolau, también denominado embolia cutis medicamentosa o dermatitis livedoide, es una vasculopatía muy rara pero una complicación muy seria que se produce tras la aplicación intramuscular o parenteral de un fármaco generando necrosis de la piel y tejidos blandos en los sitios de inyección, llegando así a su diagnóstico entre causa y efecto. Su manejo requiere tratamiento multidisciplinar de acuerdo con la extensión, profundidad y ubicación de las lesiones, con tratamiento oral, tópico y/o quirúrgico. Según el tipo de defecto residual, serán necesarios injertos de piel o colgajos locales de avance, en isla, de rotación o trasposición para su reconstrucción. El objetivo de este trabajo es familiarizar al personal de salud dedicado a la Cirugía Plástica sobre su existencia y el rol importante que tiene en la reconstrucción de estos defectos. Nivel de evidencia científica 4d Terapéutico]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Nicolau Syndrome, also called drug-induced cutaneous embolism or livedoid dermatitis, is a very rare vasculopathy but a serious complication generated by the intramuscular or parenteral application of a medicament generating skin and soft tissue necrosis at the injection site, thus reaching a diagnosis between cause and effect. Management requires multidisciplinary treatment according to the extension, depth, and location of the lesions with oral, topical and/or surgical approach. Based on the residual defect, skin grafts or flaps: local advancement, island, rotation or transposition, will be required for their reconstruction. The aim of this paper is to familiarize the Plastic Surgery healthcare personnel with its existence and the important role they play in the reconstruction of the defect. Level of evidence 4d Therapeutic]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Nicolau Syndrome]]></kwd>
<kwd lng="en"><![CDATA[Embolism cutis]]></kwd>
<kwd lng="en"><![CDATA[Dypirone.]]></kwd>
<kwd lng="es"><![CDATA[Síndrome de Nicolau]]></kwd>
<kwd lng="es"><![CDATA[Embolia cutis medicamentosa]]></kwd>
<kwd lng="es"><![CDATA[Dipirona.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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