<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0465-546X</journal-id>
<journal-title><![CDATA[Medicina y Seguridad del Trabajo]]></journal-title>
<abbrev-journal-title><![CDATA[Med. segur. trab.]]></abbrev-journal-title>
<issn>0465-546X</issn>
<publisher>
<publisher-name><![CDATA[Escuela Nacional de Medicina del Trabajo. Instituto de Salud Carlos III]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0465-546X2018000100089</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Óxido Nítrico como biomarcador en asma ocupacional inducida por isocianatos en talleres de pintura automotriz]]></article-title>
<article-title xml:lang="en"><![CDATA[Nitric-Oxide as Biomarker in Isocyanate-Induced Occupational Asthma at the Vehicle Paint and Body Repair Industry]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fumero Lessmann]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez Vólquez]]></surname>
<given-names><![CDATA[Lídia Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meza Caballero]]></surname>
<given-names><![CDATA[María Eva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidad Docente de Medicina del Trabajo de Asturias  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidad Docente de Medicina del Trabajo de la Comunidad de Madrid  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<volume>64</volume>
<numero>250</numero>
<fpage>89</fpage>
<lpage>103</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0465-546X2018000100089&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0465-546X2018000100089&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0465-546X2018000100089&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El asma ocupacional (AO) es la enfermedad respiratoria de origen laboral más prevalente en los países desarrollados. Ocurre principalmente por exposición inhalatoria a agentes como el isocianato, contenido en las pinturas utilizadas en el sector automotriz. Su diagnóstico depende de varios factores y está en estudio la utilidad de la fracción espirada de óxido nítrico (FeNO) como marcador de inflamación respiratoria, siendo un método sencillo, rápido y no invasivo. Este trabajo resume la evidencia científica sobre la utilidad de FeNO en la evaluación del asma inducida por isocianato.  Material y Métodos: Se realizó una revisión sistemática de la literatura científica publicada en 6 bases de datos, utilizando ecuaciones de búsqueda en términos MeSH. Se procedió a un cribado de las referencias y se seleccionaron los artículos basándonos en los objetivos del estudio y en los de mayor evidencia científica según SIGN.  Resultados: Se recuperaron 45 referencias y se incluyeron 8 en la revisión; 7 de ellos fueron de diseño transversal. Hubo asociación estadísticamente significativa entre hiperreactividad bronquial (HRB) y FeNO en trabajadores expuestos a isocianato en todos los artículos, con excepción de uno.  Conclusiones: A pesar de las limitaciones en los estudios revisados en cuanto al tipo de diseño, tamaño de la muestra y objetivos, se demuestra que existe evidencia científica que apoya la utilidad del FeNO en la evaluación del asma ocupacional por isocianatos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Occupational asthma (AO) is the most predominant work-related respiratory illness in developing countries. It shows up mainly due to the inhalation of agents like isocyanate, a compound used during automobile painting application and widely used in the vehicle body repair industry. Its diagnosis is multifactorial. The nitric oxide fraction concentration in exhaled breath (FeNO) as a marker of respiratory inflammation is a simple, fast and non-invasive method. This paper summarizes the scientific evidence on the usefulness of FeNO in the assessment of isocyanate induced asthma.  Material and Methods: A systematic review of the published scientific literature was carried out in 6 databases, using search equations in terms of MeSH. The references were filtered and the articles were selected based on the objectives of the study and on the highest scientific evidence according to SIGN.  Results: 45 references were retrieved and 8 were included in the review; 7 of them were of transversal design. With the exception of one of them, there was a statistically significant association between bronchial hyperresponsiveness (BHP) and FeNO in isocyanate exposed workers in all articles.  Conclusions: Despite the limitations of the reviewed studies regarding design type, sample size and objectives, it is showed that there is scientific evidence supporting the validity of FeNO in the assessment of occupational asthma by isocyanates.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Asma ocupacional]]></kwd>
<kwd lng="es"><![CDATA[isocianato]]></kwd>
<kwd lng="es"><![CDATA[óxido nítrico]]></kwd>
<kwd lng="es"><![CDATA[pintura]]></kwd>
<kwd lng="es"><![CDATA[automóviles]]></kwd>
<kwd lng="en"><![CDATA[Occupational asthma]]></kwd>
<kwd lng="en"><![CDATA[isocyanate]]></kwd>
<kwd lng="en"><![CDATA[nitric oxide]]></kwd>
<kwd lng="en"><![CDATA[paint]]></kwd>
<kwd lng="en"><![CDATA[automobiles]]></kwd>
</kwd-group>
</article-meta>
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