<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0465-546X</journal-id>
<journal-title><![CDATA[Medicina y Seguridad del Trabajo]]></journal-title>
<abbrev-journal-title><![CDATA[Med. segur. trab.]]></abbrev-journal-title>
<issn>0465-546X</issn>
<publisher>
<publisher-name><![CDATA[Escuela Nacional de Medicina del Trabajo. Instituto de Salud Carlos III]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0465-546X2018000300295</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Revisión Sistemática sobre los efectos tóxicos de las nanopartículas metálicas en la salud de los trabajadores]]></article-title>
<article-title xml:lang="en"><![CDATA[Systematic Review of Toxic Effects of Metal Nanoparticles on Workers&#8217; Health]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santana Báez]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza Martín]]></surname>
<given-names><![CDATA[Mariazel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quevedo Villegas]]></surname>
<given-names><![CDATA[María Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez Disla]]></surname>
<given-names><![CDATA[Edgar Josue]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidad Docente Médica de Salud Laboral de Canarias  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidad Docente Médica de Castilla y León  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<volume>64</volume>
<numero>252</numero>
<fpage>295</fpage>
<lpage>311</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0465-546X2018000300295&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0465-546X2018000300295&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0465-546X2018000300295&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La exposición a nanopartículas metálicas se ha incrementado en los últimos años de forma significativa debido a su mayor utilización en diversos sectores industriales. A pesar del número creciente de industrias y trabajadores expuestos, existen pocos estudios que evalúen los riesgos para la seguridad y salud de estos trabajadores.  Objetivo: Revisar la evidencia científica para determinar los posibles efectos tóxicos de las nanopartículas metálicas en la salud de los trabajadores expuestos.  Metodología: Revisión sistemática de la literatura científica mediante búsqueda en las bases de datos MEDLINE (PUBMED), WOS, SCIELO, IBECS y LILACS hasta el 10 de diciembre de 2017.  Resultados: Se incluyeron 6 artículos científicos que cumplían los criterios de selección. Las principales nanopartículas identificadas fueron hierro, cromo, manganeso, níquel, aluminio, zinc, cobre y plata. Los estudios objetivaron daños a la salud como aumento de sustancias proinflamatorias, aumento de la agregación de macrófagos, proliferación de fibroblastos, producción de especies reactivas de oxígeno, daños en la mitocondria y el ADN, y datos de daño cardiovascular, pulmonar y renal.  Conclusiones: Existen pocas investigaciones científicas relativas al daño a la salud por exposición laboral a nanopartículas metálicas. Es necesario fomentar la realización de más trabajos sobre el tema, ya que los estudios existentes demuestran una asociación entre la exposición a nanopartículas metálicas y la presencia de toxicidad cardiovascular, renal y pulmonar.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The exposure to metal nanoparticles has significantly increased in recent years due to its greater use in various industrial sectors. Despite the growing number of industries and workers exposed, there are few studies that evaluate the significant impact on the health and safety of workers.  Objective:  To review the scientific evidence to determine the possible toxic effects of metallic nanoparticles on the health of exposed workers.  Methodology:  Systematic review of the scientific literature through search in MEDLINE (PUBMED), WOS, SCIELO, IBECS and LILACS databases until 10 December, 2017.  Results: The 6 scientific articles included met the selection criteria. The main nanoparticles identified were iron, chromium, manganese, nickel, aluminium, zinc, copper and silver. The studies observed health damages like an increase in proinflammatory substances, increase in macrophage aggregation, proliferation of fibroblasts, production of reactive oxygen species, damage to mitochondria and DNA, and cardiovascular, pulmonary and renal damage data.  Conclusions: There are not many scientific studies related to the health effects associated with occupational exposure to metallic nanoparticles. Since current works evidence an association between exposure to metal nanoparticles and the presence of cardiovascular, renal and pulmonary toxicity, further investigation on the subject is necessary to be enhanced.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[revisión sistemática]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas metálicas]]></kwd>
<kwd lng="es"><![CDATA[exposición profesional]]></kwd>
<kwd lng="en"><![CDATA[Systematic review]]></kwd>
<kwd lng="en"><![CDATA[metallic nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[professional exposure]]></kwd>
</kwd-group>
</article-meta>
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