0465-546X 0465-546X S0465-546X2025000400224 10.4321/s0465-546x2025000400001 España 00 12 2025 00 12 2025 71 281 224 227 1 2007 53 206 206 2 2020 66 260 260 141-2 3 2012 58 226 226 1-5 4 2007 53 207 207 5-10 5 2017 63 246 246 1-3 6 2022 67 263 263 84-7 7 2024 70 274 274 6-9 8 Instituto de Salud Carlos III 2024