<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1130-0558</journal-id>
<journal-title><![CDATA[Revista Española de Cirugía Oral y Maxilofacial]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Esp Cirug Oral y Maxilofac]]></abbrev-journal-title>
<issn>1130-0558</issn>
<publisher>
<publisher-name><![CDATA[ Sociedad Española de Cirugía Oral y Maxilofacial y de Cabeza y Cuello]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1130-05582021000200071</article-id>
<article-id pub-id-type="doi">10.20986/recom.2021.1261/2021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Epidermodisplasia verruciforme como una entidad predisponente para carcinoma escamocelular en cabeza y cuello. Relato de un caso clínico familiar]]></article-title>
<article-title xml:lang="en"><![CDATA[Epidermodysplasia verruciformis as a predisposal entity for squamous cell carcinoma. A familial case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán Castillo]]></surname>
<given-names><![CDATA[Galo Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vásconez Escobar]]></surname>
<given-names><![CDATA[Judith Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Cortes]]></surname>
<given-names><![CDATA[Elio Fabio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno Torres]]></surname>
<given-names><![CDATA[Andrey]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gnecco Stouvenel]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pontificia Universidad Javeriana Instituto Nacional de Cancerología Servicio de Cirugía Maxilofacial]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Cancerología  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Cancerología  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Cancerología Servicio de Cabeza y Cuello ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>43</volume>
<numero>2</numero>
<fpage>71</fpage>
<lpage>75</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1130-05582021000200071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1130-05582021000200071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1130-05582021000200071&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La epidermodisplasia verruciforme (EV) es una genodermatosis rara, caracterizada por producir susceptibilidad a la infección por el virus del papiloma humano (VPH) y la consecuente aparición de tumores malignos en la piel expuesta al sol. Dentro de estos, el más frecuente es el carcinoma escamocelular. Presentamos un reporte de caso familiar con el antecedente de EV de dos hermanos que se encontraban en estadios avanzados de carcinoma escamocelular en región facial, además de lesiones en miembros superiores, quienes fueron sometidos a resección quirúrgica amplia, vaciamiento linfático ganglionar cervical y reconstrucción con colgajos libres mediante microcirugía.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Epidermodysplasia verruciformis is a rare genodermatosis, in which there is an increased susceptibility for human papillomavirus (HPV) infection and the subsequent apparition of malignant tumours, being the squamous cell carcinoma the most frequent of those. We present this familiar case report of two male siblings who presented advanced squamous cell carcinoma in the facial area and lesions in arms and forearms, who were taken to major surgical resection, cervical lymph node resection and microvascular free flap reconstruction.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Epidermodisplasia verruciforme]]></kwd>
<kwd lng="es"><![CDATA[carcinoma escamocelular]]></kwd>
<kwd lng="es"><![CDATA[genodermatosis]]></kwd>
<kwd lng="es"><![CDATA[virus del papiloma humano]]></kwd>
<kwd lng="en"><![CDATA[Epidermodysplasia verruciformis]]></kwd>
<kwd lng="en"><![CDATA[squamous cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[human papilomavirus]]></kwd>
<kwd lng="en"><![CDATA[genodermatosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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