<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1130-0558</journal-id>
<journal-title><![CDATA[Revista Española de Cirugía Oral y Maxilofacial]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Esp Cirug Oral y Maxilofac]]></abbrev-journal-title>
<issn>1130-0558</issn>
<publisher>
<publisher-name><![CDATA[ Sociedad Española de Cirugía Oral y Maxilofacial y de Cabeza y Cuello]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1130-05582024000300002</article-id>
<article-id pub-id-type="doi">10.20986/recom.2025.1586/2024</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Salivary matrix metalloproteinase-2 as a non-invasive biomarker for oral squamous cell carcinoma: diagnostic and prognostics]]></article-title>
<article-title xml:lang="es"><![CDATA[La metaloproteinasa-2 de matriz salival como biomarcador no invasivo del carcinoma oral de células escamosas: diagnóstico y pronóstico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hema-Shree]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gayathri]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Priya-Veeraraghavan]]></surname>
<given-names><![CDATA[Vishnu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Selvaraj]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramani]]></surname>
<given-names><![CDATA[Pratibha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Saveetha Institute Medical and Technical Science Saveetha Dental College and Hospitals Department of Oral and Maxillofacial Pathology]]></institution>
<addr-line><![CDATA[Chennai ]]></addr-line>
<country>India</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Saveetha Dental College Department of Biochemistry ]]></institution>
<addr-line><![CDATA[Chennai ]]></addr-line>
<country>India</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Saveetha Institute Medical and Technical Science Saveetha Dental College and Hospitals Department of Biochemistry]]></institution>
<addr-line><![CDATA[Chennai ]]></addr-line>
<country>India</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>46</volume>
<numero>3</numero>
<fpage>110</fpage>
<lpage>118</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1130-05582024000300002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1130-05582024000300002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1130-05582024000300002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy characterized by late-stage diagnosis and high recurrence rates, underscoring the need for reliable biomarkers. Matrix metalloproteinase-2 (MMP-2), a zinc-dependent enzyme implicated in extracellular matrix degradation, has shown potential as a biomarker for OSCC progression. Saliva, being non-invasive and accessible, offers a promising medium for MMP-2 assessment.  Objectives: This study aimed to evaluate salivary MMP-2 levels in OSCC patients and healthy controls to determine its diagnostic and prognostic significance.  Methods: This clinical study included 60 participants divided into three groups: healthy controls (n = 20), pre-operative OSCC patients and post-operative OSCC patients (n = 40). Saliva samples were collected, processed, and analyzed for MMP-2 levels using ELISA. Statistical analyses, including ANOVA and post-hoc Tukey tests, were performed to compare groups. Kaplan-Meier survival analysis was used to assess the prognostic impact of MMP-2 expression.  Results: MMP-2 levels were significantly elevated in pre-operative OSCC patients (78.69 ± 2.65 ng/mL) compared to controls (36.20 ± 1.83 ng/mL; p &lt; 0.0001). Post-operative patients exhibited reduced but still elevated levels (51.88 ± 4.25 ng/mL), highlighting the partial impact of surgical intervention. Kaplan-Meier analysis revealed poorer survival probabilities in patients with high MMP-2 levels, emphasizing its prognostic value.  Conclusions: Salivary MMP-2 serves as a potential non-invasive biomarker for OSCC diagnosis, disease monitoring, and prognosis. Its incorporation into clinical practice could enhance early detection and treatment planning, improving patient outcomes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Antecedentes: El carcinoma oral de células escamosas (OSCC) es una neoplasia prevalente caracterizada por un diagnóstico tardío y altas tasas de recurrencia, lo que subraya la necesidad de biomarcadores fiables. La metaloproteinasa de matriz-2 (MMP-2), una enzima dependiente del zinc implicada en la degradación de la matriz extracelular, ha demostrado su potencial como biomarcador de la progresión del OSCC. La saliva, al ser no invasiva y accesible, ofrece un medio prometedor para la evaluación de la MMP-2.  Objetivos: El objetivo de este estudio es evaluar los niveles de MMP-2 en la saliva de pacientes con OSCC y controles sanos para determinar su importancia diagnóstica y pronóstica.  Métodos: Este estudio clínico incluyó 60 participantes divididos en tres grupos: controles sanos (n = 20), pacientes preoperatorios de OSCC y pacientes postoperatorios de OSCC (n = 40). Se recogieron, procesaron y analizaron muestras de saliva para determinar los niveles de MMP-2 mediante ELISA. Se realizaron análisis estadísticos, incluyendo ANOVA y pruebas post hoc de Tukey, para comparar los grupos. Se utilizó el análisis de supervivencia de Kaplan-Meier para evaluar el impacto pronóstico de la expresión de MMP-2.  Resultados: Los niveles de MMP-2 fueron significativamente elevados en los pacientes preoperatorios de OSCC (78,69 ± 2,65 ng/ml) en comparación con los controles (36,20 ± 1,83 ng/ml; p &lt; 0,0001). Los pacientes postoperados mostraron niveles reducidos, pero aún elevados (51,88 ± 4,25 ng/ml), lo que pone de manifiesto el impacto parcial de la intervención quirúrgica. El análisis de Kaplan-Meier reveló peores probabilidades de supervivencia en pacientes con niveles elevados de MMP-2, lo que subraya su valor pronóstico.  Conclusiones: La MMP-2 salival sirve como un biomarcador potencial no invasivo para el diagnóstico del OSCC, la monitorización de la enfermedad y el pronóstico. Su incorporación a la práctica clínica podría mejorar la detección precoz y la planificación del tratamiento, mejorando los resultados de los pacientes.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Oral squamous cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[MMP-2]]></kwd>
<kwd lng="en"><![CDATA[saliva]]></kwd>
<kwd lng="en"><![CDATA[non-invasive diagnostics]]></kwd>
<kwd lng="en"><![CDATA[biomarker]]></kwd>
<kwd lng="en"><![CDATA[prognosis]]></kwd>
<kwd lng="en"><![CDATA[ELISA]]></kwd>
<kwd lng="es"><![CDATA[Carcinoma oral de células escamosas]]></kwd>
<kwd lng="es"><![CDATA[MMP-2]]></kwd>
<kwd lng="es"><![CDATA[saliva]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico no invasivo]]></kwd>
<kwd lng="es"><![CDATA[biomarcador]]></kwd>
<kwd lng="es"><![CDATA[pronóstico]]></kwd>
<kwd lng="es"><![CDATA[ELISA]]></kwd>
</kwd-group>
</article-meta>
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