1130-6343 1130-6343 S1130-63432018000200073 10.7399/fh.10807 Spain Spain Spain Spain 00 04 2018 00 04 2018 42 2 73 81

FDA 2013 EMA 2015 EMA 2015 2015 61 ^sSupl. 2 ^sSupl. 2 Supl. 2 S69-78 2009 15 9 9 1516-8 2013 15 ^sSupl. 1 ^sSupl. 1 Supl. 1 S39-41 2014 27 2 2 115-21 2013 2014 18 9 9 57 2009 2013 19 9 9 2009 133 14 14 552-64 2014 23 349 349 5493 European Centre for Disease Prevention and Control 2015 European Medicines Agency 2015 FDA Center For Drug Evaluation And Research 2015 European Medicines Agency 2015 2012 15 ^s54(Supl. 3) ^s54(Supl. 3) 54(Supl. 3) S214-9 2013 2016 2011 55 7 7 3476-84 2014 370 23 23 2180-90 2015 60 2 2 254-62 2015 31 8 8 1539-51 2006 79 6 6 521-8 2014 17 7 7 A605 2016 36 2 2 157-68 2015 18 3 3 A233 2013 30 13 13 252