<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1130-6343</journal-id>
<journal-title><![CDATA[Farmacia Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Farm Hosp.]]></abbrev-journal-title>
<issn>1130-6343</issn>
<publisher>
<publisher-name><![CDATA[Grupo Aula Médica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1130-63432019000500005</article-id>
<article-id pub-id-type="doi">10.7399/fh.11226</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Physicochemical characterization of micafungin and anidulafungin for its nebulized administration]]></article-title>
<article-title xml:lang="es"><![CDATA[Caracterización fisicoquímica de micafungina y anidulafungina para su administración mediante nebulización]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Ganda]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Terradas-Campanario]]></surname>
<given-names><![CDATA[Sonia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campany-Herrero]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Vall d&#8217;Hebron University Hospital Pharmacy Service ]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2019</year>
</pub-date>
<volume>43</volume>
<numero>5</numero>
<fpage>163</fpage>
<lpage>165</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1130-63432019000500005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1130-63432019000500005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1130-63432019000500005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization.  Method PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry in two samples of different concentrations, 5 and 10 mg/mL each echinocandin.  Results The results obtained for micafungin solution were: pH 5.80 (0.14), osmolality 293.33 (1.53) mOsm/kg, chloride content 134.67 (0.58) mmol/L and density 1,009.4 (0,1) kg/m3; while for 10 mg/mL solution: osmolality 342.00 (1.00) mOsm/kg, chloride content 139.67 (0.58) mmol/L and density 1,014.5 (0.2) kg/m3. The results obtained for 5 mg/mL anidulafungin were: pH 4.22 (0.01), osmolality 464.67 (2.52) mOsm/kg, chloride content 137.00 (0.00) mmol/L and density 1,016.5 (0,2) kg/m3; while for 10 mg/mL solution: osmolality 656.33 (1.15) mOsm/kg, chloride content 132.00 (0.00) mmol/L and density 1,029.8 (0.4) kg/m3.  Conclusions PH, osmolality, chloride content and density values proved to be suitable for proper tolerability by nebulization.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo Determinar experimentalmente si micafungina y anidulafungina poseen propiedades fisicoquímicas adecuadas para su nebulización.  Método Se determinó el pH, la osmolalidad, la viscosidad, la densidad y el contenido en cloruros mediante pH-metría, osmometría, viscosimetría, densitometría y potenciometría, respectivamente, en dos muestras de diferente concentración, 5 y 10 mg/ml, de cada equinocandina.  Resultados Para la solución de micafungina 5 mg/ml los resultados obtenidos fueron: pH 5,80 (0,14), osmolalidad 293,33 (1,53) mOsm/kg, contenido en cloruros 134,67 (0,58) mmol/l y densidad 1.009,4 (0,1) kg/m3; y para la solución de 10 mg/ml: osmolalidad 342,00 (1,00) mOsm/kg, contenido en cloruros 139,67 (0,58) mmol/l y densidad 1.014,5 (0,2) kg/m3. Para la solución de anidulafungina 5 mg/ml los resultados obtenidos fueron: pH 4,22 (0,01), osmolalidad 464,67 (2,52) mOsm/kg, contenido en cloruros 137,00 (0,00) mmol/l y densidad 1.016,5 (0,2) kg/m3; y para la solución de 10 mg/ml: osmolalidad 656,33 (1,15) mOsm/kg, contenido en cloruros 132,00 (0,00) mmol/l y densidad 1.029,8 (0,4) kg/m3.  Conclusiones Los valores de pH, osmolalidad, contenido en cloruros y densidad resultaron adecuados para una correcta tolerabilidad mediante nebulización.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Micafungin]]></kwd>
<kwd lng="en"><![CDATA[Anidulafungin]]></kwd>
<kwd lng="en"><![CDATA[Antifungal]]></kwd>
<kwd lng="en"><![CDATA[Nebulized]]></kwd>
<kwd lng="en"><![CDATA[Scedosporium]]></kwd>
<kwd lng="en"><![CDATA[Scopulariopsis]]></kwd>
<kwd lng="es"><![CDATA[Micafungina]]></kwd>
<kwd lng="es"><![CDATA[Anidulafungina]]></kwd>
<kwd lng="es"><![CDATA[Antifúngico]]></kwd>
<kwd lng="es"><![CDATA[Nebulizado]]></kwd>
<kwd lng="es"><![CDATA[Scedosporium]]></kwd>
<kwd lng="es"><![CDATA[Scopulariopsis]]></kwd>
</kwd-group>
</article-meta>
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