<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1130-6343</journal-id>
<journal-title><![CDATA[Farmacia Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Farm Hosp.]]></abbrev-journal-title>
<issn>1130-6343</issn>
<publisher>
<publisher-name><![CDATA[Grupo Aula Médica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1130-63432020000400006</article-id>
<article-id pub-id-type="doi">10.7399/fh.11388</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[New ophthalmic drug delivery systems]]></article-title>
<article-title xml:lang="es"><![CDATA[Nuevos sistemas de liberación de fármacos a nivel ocular]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Balado]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mondelo-García]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zarra-Ferro]]></surname>
<given-names><![CDATA[Irene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Ferreiro]]></surname>
<given-names><![CDATA[Anxo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Servicio Galego de Saúde (SERGAS) Área Sanitaria de Santiago de Compostela e Barbanza Servicio de Farmacia]]></institution>
<addr-line><![CDATA[Santiago de Compostela ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Investigación Sanitaria Santiago de Compostela (IDIS) Grupo de Farmacología Clínica ]]></institution>
<addr-line><![CDATA[Santiago de Compostela ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Santiago de Compostela Departamento de Farmacología, Farmacia y Tecnología Farmacéutica Facultad de Farmacia]]></institution>
<addr-line><![CDATA[Santiago de Compostela ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>44</volume>
<numero>4</numero>
<fpage>149</fpage>
<lpage>157</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1130-63432020000400006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1130-63432020000400006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1130-63432020000400006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract For decades, topical ophthalmic drug administration through the use of eye drops has been the most widely used technique for the treatment of eye diseases. The development of galenic formulation has led to the use and commercialization of new formulations, such as suspensions, emulsions, and ophthalmic ointments that increase residence time in the site of action. Recently, new administration systems have been developed, such as devices and inserts that provide the sustained release of active substance. Some of these systems are already available on the market, whereas others are still undergoing clinical trials, such as promising systems based on nanostructures (nanocapsules, cyclodextrins, nanoemulsions, etc.). Similarly, various formulations and devices have been developed in the field of intravitreal administration, with different implants available on the European market for the treatment of age-related macular degeneration (AMD), diabetic macular edema, or infections that affect the posterior segment. This review includes current developments in ophthalmic topical and intravitreal drug administration routes as well as those under investigation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Desde hace décadas, la administración tópica oftálmica de fármacos mediante el empleo de colirios ha sido la técnica más empleada para el tratamiento de patologías oculares. El desarrollo de la galénica ha permitido el uso y comercialización de nuevas formulaciones que incrementan el tiempo de residencia en el lugar de acción, como es el caso de las suspensiones, emulsiones y pomadas oftálmicas. Recientemente se han desarrollado nuevos sistemas de administración, como es el caso de dispositivos e insertos que proporcionan una cesión sostenida de principio activo. Algunos de estos sistemas ya se encuentran disponibles en el mercado, mientras que otros todavía están en fase de ensayo clínico, como es el caso también de los prometedores sistemas basados en nanoestructuras (nanocápsulas, ciclodextrinas, nanoemulsiones, etc.). De la misma forma, diversas formulaciones y dispositivos han sido desarrollados en el campo de la administración intravítrea, estando disponibles en el mercado europeo diversos implantes para el tratamiento de la degeneración macular asociada a la edad (DMAE), el edema macular diabético o infecciones que afectan al segmento posterior. En esta revisión se recogen los desarrollos actualmente implementados y en fase de investigación asociados a las vías de administración oftálmica de fármacos tópicos e intravítreos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Ophthalmic solutions]]></kwd>
<kwd lng="en"><![CDATA[Intravitreal injections]]></kwd>
<kwd lng="en"><![CDATA[Ocular inserts]]></kwd>
<kwd lng="en"><![CDATA[Drug delivery systems]]></kwd>
<kwd lng="es"><![CDATA[Soluciones oftálmicas]]></kwd>
<kwd lng="es"><![CDATA[Inyecciones intravítreas]]></kwd>
<kwd lng="es"><![CDATA[Insertos oculares]]></kwd>
<kwd lng="es"><![CDATA[Sistemas de liberación oftálmica]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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