<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1130-6343</journal-id>
<journal-title><![CDATA[Farmacia Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Farm Hosp.]]></abbrev-journal-title>
<issn>1130-6343</issn>
<publisher>
<publisher-name><![CDATA[Grupo Aula Médica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1130-63432022000600008</article-id>
<article-id pub-id-type="doi">10.7399/fh.13288</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Farmacocinética poblacional de la digoxina en pacientes de edad avanzada: una revisión sistemática]]></article-title>
<article-title xml:lang="en"><![CDATA[Population pharmacokinetics of digoxin in elderly patients: a systematic review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salcedo-Mingoarranz]]></surname>
<given-names><![CDATA[Ángel Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Díaz]]></surname>
<given-names><![CDATA[Benito]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barcia-Hernández]]></surname>
<given-names><![CDATA[Emilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Severo Ochoa Servicio de Farmacia ]]></institution>
<addr-line><![CDATA[Leganés Madrid]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Complutense de Madrid Facultad de Farmacia Departamento de Farmacia Galénica y Tecnología Alimentaria]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>46</volume>
<numero>6</numero>
<fpage>359</fpage>
<lpage>366</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1130-63432022000600008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1130-63432022000600008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1130-63432022000600008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Resumir la literatura disponible sobre los estudios de farmacocinética poblacional de digoxina en pacientes de edad avanzada e identificar los cambios fisiopatológicos en esta subpoblación, que conllevan implicaciones clínicas en la farmacocinética de la digoxina.  Método: Se realizó una revisión sistemática de los estudios de farmacocinética poblacional en pacientes ancianos que recibían digoxina. Se utilizaron PubMed, ISI Web of Science, SCOPUS y Science Direct para identificar los artículos con los descriptores (&#8220;Digoxin&#8221;[Mesh]) AND (&#8220;Pharmacokinetics&#8221;[Mesh]) AND (&#8220;Aged&#8221;[Mesh] OR &#8220;Elderly&#8221;[Mesh]), seguido de una búsqueda manual.  Resultados: Se encontraron y revisaron nueve estudios, cinco de los cuales de desarrollaron en pacientes asiáticos. Se utilizó NONMEM para el análisis farmacocinético de los niveles plasmáticos de la digoxina, mayoritariamente descrita como un modelo monocompartimental.  Conclusiones: Los pacientes ancianos presentan cambios fisiopatológicos con gran influencia en la farmacocinética de muchos fármacos. Las covariables con un mayor impacto en la farmacocinética de la digoxina deben tenerse en cuenta al ajustar la dosis de este medicamento en pacientes de edad avanzada con el fin de lograr beneficios óptimos para la salud y prevenir posibles efectos adversos en esta subpoblación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: To resume the available literature about digoxin population pharmacokinetic studies in elderly patients. To identify the pathophysiological changes in this subpopulation with clinical implications on digoxin pharmacokinetics.  Method: A systematic review was performed regarding the population pharmacokinetic studies in elderly patients receiving digoxin. PubMed, ISI Web of Science, SCOPUS and Science Direct were used to identify the articles with the descriptors (&#8220;Digoxin&#8221;[Mesh]) AND (&#8220;Pharmacokinetics&#8221;[Mesh]) AND (&#8220;Aged&#8221;[Mesh] OR &#8220;Elderly&#8221;[Mesh]), followed by a manual search.  Results: Nine studies were found and reviewed, five of them carried out in Asian patients. NONMEM was used for pharmacokinetic analysis of digoxin blood levels, being mostly described by a one-compartment model. Serum creatinine, body weight and concomitant administration of calcium channel blockers are the covariates that most frequently influence digoxin pharmacokinetics in elderly patients.  Conclusions: Elderly people present pathophysiological changes with influence on the pharmacokinetics of many drugs. The covariates with most influence on digoxin pharmacokinetics should be considered when adjusting this drug dosage in elder patients to achieve optimum health benefits and prevent possible side effects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Farmacocinética poblacional]]></kwd>
<kwd lng="es"><![CDATA[Digoxina]]></kwd>
<kwd lng="es"><![CDATA[Ancianos]]></kwd>
<kwd lng="es"><![CDATA[Revisión]]></kwd>
<kwd lng="en"><![CDATA[Population pharmacokinetics]]></kwd>
<kwd lng="en"><![CDATA[Digoxin]]></kwd>
<kwd lng="en"><![CDATA[Elderly]]></kwd>
<kwd lng="en"><![CDATA[Systematic review]]></kwd>
</kwd-group>
</article-meta>
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