<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462017000400188</article-id>
<article-id pub-id-type="doi">10.20986/resed.2017.3586/2017</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Fentanilo: una molécula y múltiples formulaciones galénicas de trascendencia clínica en el tratamiento del dolor irruptivo oncológico]]></article-title>
<article-title xml:lang="en"><![CDATA[Fentanyl: a molecule and multiple dose formulations of clinical transcendence in the in the treatment of breakthrough cancer pain]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álamo]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zaragozá-Arnáez]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Noriega-Matanza]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[M.-Torres]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Alcalá Facultad de Medicina y Ciencias de la Salud Departamento de Ciencias biomédicas]]></institution>
<addr-line><![CDATA[Alcalá de Henares Madrid]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Alcalá Facultad de Medicina y Ciencias de la Salud Departamento de Enfermería y Fisioterapia]]></institution>
<addr-line><![CDATA[Alcalá de Henares Madrid]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario Puerta del Mar Servicio de Anestesiología, Reanimación y Tratamiento del Dolor ]]></institution>
<addr-line><![CDATA[Cádiz ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2017</year>
</pub-date>
<volume>24</volume>
<numero>4</numero>
<fpage>188</fpage>
<lpage>200</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462017000400188&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462017000400188&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462017000400188&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El manejo del dolor irruptivo oncológico exige tener prevista una medicación "de rescate" con opioides de liberación rápida. Sin embargo, pese a la existencia de medios para su control, este es muchas veces inadecuado. La mayoría de los autores señalan que el inicio y la duración de la acción de los opiáceos orales no son las adecuadas para el tratamiento del dolor irruptivo. Los opioides de acción rápida, especialmente el fentanilo, son los fármacos de elección para el tratamiento del dolor irruptivo. En este trabajo se revisan las características de las diferentes formulaciones transmucosas bucales, sublinguales e intranasales de fentanilo que, pese a ser siempre la misma molécula, tienen matices diferenciales de importancia. De hecho, estas presentaciones no son intercambiables. La elección del tratamiento más adecuado para cada paciente debe tener en consideración los perfiles farmacocinéticos de las distintas formulaciones, ya que estas definen cuándo se inicia el efecto, cuánto dura la analgesia y cuál es el nivel del pico plasmático máximo (Cmax), muchas veces responsable de los efectos adversos. La bibliografía general y diversos consensos de expertos recomiendan individualizar el tratamiento tras una cuidadosa evaluación del dolor. Las dosis de productos de fentanilo administradas deben tener en cuenta el nivel de tolerancia opioide de los pacientes, el perfil farmacocinético de cada preparado y las condiciones de cada paciente en relación con las vías de administración. En determinadas circunstancias clínicas, las presentaciones de fentanilo intranasal parece tener un inicio de acción más rápido y ser mejor toleradas desde el punto digestivo que las presentaciones transmucosas orales. La preferencia del paciente debe también tenerse en consideración.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The breakthrough cancer pain management requires planned a "rescue" medication with quick-release opioids. However, despite the existence of media for their control, this is often inappropriate. Most of the authors point out that the onset and duration of action of oral opioids are not appropriate for the treatment of breakthrough pain. Fast-acting opioid, notably fentanyl, are the drugs of choice for the treatment of breakthrough pain. This paper reviews the characteristics of the different transmucosal formulations of fentanyl that, despite the same molecule, have differential degrees of importance. In fact, these presentations are not interchangeable. The choice of the most appropriate treatment for each patient should take into consideration the different Pharmacokinetic profiles, since they define when the effect starts, how long lasting analgesia and what is the level of the plasma peak (Cmax), often responsible for the adverse effects. General bibliography and various consensus of experts recommended to individualize the treatment after a carefully evaluation of the pain. Administered doses of different fentanyl formulations must take into account patient's opioid tolerance, the pharmacokinetic profile of each products and conditions of each patient in relation to the routes of administration. In certain clinical circumstances, intranasal fentanyl appears to have a faster onset of action and be better tolerated at the gastrointestinal level that buccal presentations. The preference of the patient must also be taken into consideration.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[breakthrough cancer pain]]></kwd>
<kwd lng="es"><![CDATA[dolor irruptivo oncológico]]></kwd>
</kwd-group>
</article-meta>
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