<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462017000600324</article-id>
<article-id pub-id-type="doi">10.20986/resed.2016.3508/2016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Terapias intervencionistas para manejo de dolor en osteoartrosis de rodilla sintomática]]></article-title>
<article-title xml:lang="en"><![CDATA[Interventional therapies for pain management in symptomatic knee osteoarthrosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco-Arango]]></surname>
<given-names><![CDATA[J.-A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Departamental Universitario Santa Sofía de Caldos Instituto Caldense de Medicina del Dolor ]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>24</volume>
<numero>6</numero>
<fpage>324</fpage>
<lpage>332</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462017000600324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462017000600324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462017000600324&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La osteoartrosis (OA) de rodilla es el tipo más común de OA. Es un desorden multifactorial donde el dolor es la característica clínica más importante. El tratamiento analgésico en la OA de rodilla usualmente comienza con acetaminofén y antinflamatorios no esteroideos. El manejo intervencionista no quirúrgico está indicado en la gonartrosis sintomática no quirúrgica sin respuesta a tratamiento analgésico y antinflamatorio vía oral y tópica, así como en la gonartrosis en fase quirúrgica cuando la cirugía sea desaconsejable o esté contraindicada.  Objetivos:  Hacer una revisión crítica sobre la evidencia actual para las siguientes terapias intrarticulares (IA): corticoesteroides, ácido hialurónico (AH), ozono, plasma rico en plaquetas (PRP), toxina botulínica (TBA) y radiofrecuencia de nervios geniculados.  Metodología:  Se hizo una búsqueda y revisión no sistemática de artículos individuales, revisiones sistemáticas y metanálisis.  Resultados y conclusiones:  Los esteroides IA son efectivos, principalmente en aquellos con mayor compromiso radiográfico, con un nivel de evidencia 1B. El PRP y AH son útiles en pacientes con gonartrosis leve a moderada pero no en gonartrosis severa, con una mayor duración del efecto para el PRP. En grados severos de gonartrosis (grado III-IV), la terapia más indicada es la radiofrecuencia de nervios geniculados. La toxina botulínica es superior a los esteroides IA con adecuada respuesta en los diferentes grados de artrosis, incluso cuando las demás terapias no han logrado una respuesta adecuada. Todas las terapias revisadas han sido efectivas para mejoría del dolor en gonartrosis; sin embargo, hay gran controversia sobre el grado de recomendación para cada una de las terapias, esto debido a la gran variabilidad en los fenotipos de los pacientes incluidos en los diferentes estudios, lo que limita generalizar los resultados y dificulta el enfoque de los pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Osteoarthritis (OA) of knee is the most common type of OA. It is a multifactorial disorder where pain is the most important clinical feature. Analgesic treatment in knee OA usually begins with acetaminophen and NSAIDs. Nonsurgical interventional indicated on nonsurgical symptomatic knee OA unresponsive to analgesic and anti-inflammatory oral and topical treatment, as well as knee osteoarthritis in surgery, when surgery is contraindicated or inadvisable.  Objectives:  A critical review of the current evidence for the following therapies intraarticular (IA): corticosteroids, hyaluronic acid (HA), ozone, platelet-rich plasma (PRP), botulinum toxin and RF geniculate nerves.  Methodology:  A search and no systematic review of individual articles, systematic reviews, meta-analysis was performed.  Results and conclusions:  IA steroids are effective, especially in those with greater radiographic commitment, with a level of evidence 1B. The PRP and AH, are useful in patients with mild to moderate knee osteoarthritis but not in severe knee osteoarthritis, with a longer duration of effect for the PRP. In severe degrees of gonarthrosis (Grades III-IV), the most suitable therapy is the RF geniculate nerves. Botulinum toxin, is superior to IA steroids with adequate response in different degrees of arthrosis, even when other therapies have not achieved adequate response. All therapies have been revised effective pain relief in knee osteoarthritis. However, there is great controversy over the degree of recommendation for each of the therapies, this because of the great variability in the phenotypes of patients included in the different studies, limiting generalizability of the results and hinders the approach of patients.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Interventional therapies]]></kwd>
<kwd lng="en"><![CDATA[knee osteoarthrosis]]></kwd>
<kwd lng="en"><![CDATA[corticosteroid]]></kwd>
<kwd lng="en"><![CDATA[hyaluronic acid]]></kwd>
<kwd lng="en"><![CDATA[platelet-rich plasma]]></kwd>
<kwd lng="en"><![CDATA[botulinum toxins]]></kwd>
<kwd lng="en"><![CDATA[ozone]]></kwd>
<kwd lng="en"><![CDATA[radiofrequency]]></kwd>
<kwd lng="es"><![CDATA[Terapias intervencionistas]]></kwd>
<kwd lng="es"><![CDATA[osteoartrosis de rodilla]]></kwd>
<kwd lng="es"><![CDATA[corticosteroides]]></kwd>
<kwd lng="es"><![CDATA[ácido hialurónico]]></kwd>
<kwd lng="es"><![CDATA[plasma rico en plaquetas]]></kwd>
<kwd lng="es"><![CDATA[toxina botulínica]]></kwd>
<kwd lng="es"><![CDATA[ozono]]></kwd>
<kwd lng="es"><![CDATA[radiofrecuencia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis A Pilot Study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Delgado]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Muiños-López]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Paiva]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Granero-Moltó]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Biomed Res Int]]></source>
<year>2016</year>
<volume>2016</volume>
<page-range>4868613</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sotos Borrás]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
<name>
<surname><![CDATA[López Gómez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández García]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Rehabilitación Intervencionista]]></source>
<year>2012</year>
<publisher-loc><![CDATA[Madrid ]]></publisher-loc>
<publisher-name><![CDATA[Ergon]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pain sensitivity profiles in patients with advanced kneeosteoarthritis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frey-Law]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Bohr]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Sluka]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Herr]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[CR]]></given-names>
</name>
<name>
<surname><![CDATA[Noiseux]]></surname>
<given-names><![CDATA[NO]]></given-names>
</name>
</person-group>
<source><![CDATA[Pain]]></source>
<year>2016</year>
<volume>157</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1988-99</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Radiofrequency Thermocoagulation in Relieving Refractory Pain of Knee Osteoarthritis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[WS]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[XQ]]></given-names>
</name>
<name>
<surname><![CDATA[Zhai]]></surname>
<given-names><![CDATA[NN]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[ZS]]></given-names>
</name>
<name>
<surname><![CDATA[Shao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[YH]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Ther]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Subjects with Knee Osteoarthritis Exhibitm Widespread Hyperalgesia to Pressure and Cold]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moss]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Knight]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS One]]></source>
<year>2016</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>e0147526</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hylan G-F 20 versus low molecular weight hyaluronic acids for knee osteoarthritis A meta-analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[BioDrugs]]></source>
<year>2016</year>
<volume>30</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>387-96</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: A randomized, double-blind, placebocontrolled trial]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Görmeli]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Görmeli]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Ataoglu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Çolak]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Aslantürk]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Ertem]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Knee Surg Sports Traumatol Arthrosc]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The discrepancy between recommendations and clinical practice for viscosupplementation in osteoarthritis: Mind the gap!]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Migliore]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bizzi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Herrero-Beaumont]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Petrella]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Raman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Chevalier]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur Rev Med Pharmacol Sci]]></source>
<year>2015</year>
<volume>19</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1124-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis A network meta-analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[da Costa]]></surname>
<given-names><![CDATA[BR]]></given-names>
</name>
<name>
<surname><![CDATA[Reichenbach]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Keller]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Nartey]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wandel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Jüni]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2016</year>
<volume>387</volume>
<numero>10033</numero>
<issue>10033</issue>
<page-range>2093-105</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Topical capsaicin for pain in osteoarthritis: A literature review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guedes]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Reumatol Clin]]></source>
<year>2016</year>
<volume>16</volume>
<page-range>30089-4</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intra-Articular corticosteroids in addition to exercise for reducing pain sensitivity in knee osteoarthritis Exploratory outcome from a randomized controlled trial]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Soriano-Maldonado]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Klokker]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bartholdy]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bandak]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Ellegaard]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Bliddal]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS One]]></source>
<year>2016</year>
<volume>11</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>e0149168</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Predictors of response to intraarticular steroid injections in patients with osteoarthritis of the knee joint]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fatimah]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Salim]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Raja]]></surname>
<given-names><![CDATA[EU]]></given-names>
</name>
<name>
<surname><![CDATA[Nasim]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Rheumatol]]></source>
<year>2016</year>
<volume>35</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2541-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evidence and recommendations for use of intra-articular injections for knee osteoarthritis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lefèvre-Colau]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Poiraudeau]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rannou]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Phys Rehabil Med]]></source>
<year>2016</year>
<volume>59</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>184-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee A systematic review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Altman]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
<name>
<surname><![CDATA[Manjoo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fierlinger]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Niazi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Nicholls]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[BMC Musculoskelet Disord]]></source>
<year>2015</year>
<volume>16</volume>
<page-range>321</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hylan versus hyaluronic acid for osteoarthritis of the knee A systematic review and meta-analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reichenbach]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Blank]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rutjes]]></surname>
<given-names><![CDATA[AW]]></given-names>
</name>
<name>
<surname><![CDATA[Shang]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[King]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Dieppe]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<source><![CDATA[Arthritis Rheum]]></source>
<year>2007</year>
<volume>57</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1410-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Altman]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
<name>
<surname><![CDATA[Bedi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Karlsson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sancheti]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Schemitsch]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Sports Med]]></source>
<year>2016</year>
<volume>44</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2158-65</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ozonoterapia en medicina del dolor Revisión]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hidalgo-Tallón]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Soc Esp Dolor]]></source>
<year>2013</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>291-300</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparative efficacy of intraarticular injection of combination of ozone and steroid and ozone alone in patients with primary knee osteoarthritis A prospective, randomized clinical analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chansoria]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Upadhyay]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Panwar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Shivhare]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Vyas]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[J Recent Adv Pain]]></source>
<year>2016</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>11-4</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ozone therapy in rheumatic diseases: A systematic review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carmona]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Reumatol Clin]]></source>
<year>2006</year>
<volume>2</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>119-23</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Radiological assessment of osteo-arthrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellgren]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Lawrence]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Rheum Dis]]></source>
<year>1957</year>
<volume>16</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>494-502</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation A randomized controlled trial]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Filardo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Di Matteo]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Di Martino]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Merli]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Cenacchi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fornasari]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Sports Med]]></source>
<year>2015</year>
<volume>43</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1575-82</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain A randomized clinical trial in the context of the spanish national health care system]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Montañez-Heredia]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Irízar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Huertas]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Otero]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[del Valle]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Prat]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2016</year>
<volume>17</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>pii</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Usefulness of intra-articular botulinum toxin injections]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khenioui]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Houvenagel]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Catanzariti]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Guyot]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Agnani]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Donze]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[A systematic review Joint Bone Spine]]></source>
<year>2016</year>
<volume>83</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>149-54</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Efectos de la toxina botulínica A (Botox(r)) intraarticular en la artrosis de rodilla avanzada]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fenollosa Vázquez]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Izquierdo Aguirre]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Canós Verdecho]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Pallarés Delgado]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Soc Esp Dolor]]></source>
<year>2011</year>
<volume>18</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>320-5</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of botulinum toxin landmark-guided intra-articular injection in subjects with knee osteoarthritis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hsieh]]></surname>
<given-names><![CDATA[LF]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
<name>
<surname><![CDATA[Chou]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[YJ]]></given-names>
</name>
</person-group>
<source><![CDATA[PMR]]></source>
<year>2016</year>
<volume>8</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1127-35</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Extra articular management of knee osteoarthritis pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thapa]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ahuja]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Verma]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dass]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Pain Med]]></source>
<year>2015</year>
<volume>16</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1846-7</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pulsed radiofrequency of the composite nerve supply to the knee joint as a new technique for relieving osteoarthritic pain A preliminary report]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pai]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Khandagale]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pattnaik]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Pain Physician]]></source>
<year>2014</year>
<volume>17</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>493-506</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Eficacia de la radiofrecuencia convencional de geniculados para el tratamiento del dolor en gonartrosis moderada-severa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramírez Ogalla]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno Martín]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Santana Pineda]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez Huertas]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Soc Esp Dolor]]></source>
<year>2014</year>
<volume>21</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>212-8</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pulse-dose radiofrequency for knee osteoartrithis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Masala]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fiori]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Raguso]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Morini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Calabria]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Simonetti]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Cardiovasc Intervent Radiol]]></source>
<year>2014</year>
<volume>37</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>482-7</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Is genicular nerve radiofrequency ablation safe A literature review and anatomical study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[SY]]></given-names>
</name>
<name>
<surname><![CDATA[Le]]></surname>
<given-names><![CDATA[PU]]></given-names>
</name>
<name>
<surname><![CDATA[Kosharskyy]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kaye]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Shaparin]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Downie]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<source><![CDATA[Pain Physician]]></source>
<year>2016</year>
<volume>19</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>E697-705</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Radiofrequency neurotomy for the treatment of chronic pain interference with implantable medical devices]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barbieri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bellini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Anaesthesiol Intensive Ther]]></source>
<year>2014</year>
<volume>46</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>162-5</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robinson]]></surname>
<given-names><![CDATA[WH]]></given-names>
</name>
<name>
<surname><![CDATA[Lepus]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Raghu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mao]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lindstrom]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Rheumatol]]></source>
<year>2016</year>
<volume>12</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>580-92</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Validation of the Spanish version of the WOMAC questionnaire for patients with hip or knee osteoarthritis Western Ontario and McMaster Universities Osteoarthritis Index]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Escobar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Quintana]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Bilbao]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Azkarate]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guenaga]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Rheumatol]]></source>
<year>2002</year>
<volume>21</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>466-71</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intra-articular corticosteroid for knee osteoarthritis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jüni]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hari]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rutjes]]></surname>
<given-names><![CDATA[AW]]></given-names>
</name>
<name>
<surname><![CDATA[Fischer]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Silletta]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Reichenbach]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2015</year>
<numero>10</numero>
<issue>10</issue>
<page-range>CD005328</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Viscosupplementation for Osteoarthritis of the Knee A Systematic Review of the Evidence]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jevsevar]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Donnelly]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Cummins]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
</person-group>
<source><![CDATA[J Bone Joint Surg Am]]></source>
<year>2015</year>
<volume>97</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>2047-60</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Giombini]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Menotti]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Di Cesare]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Giovannangeli]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rizzo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Moffa]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Regul Homeost Agents]]></source>
<year>2016</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>621-5</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Choice of intra-articular injection in treatment of knee osteoarthritis Platelet-rich plasma, hyaluronic acid or ozone options]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duymus]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Mutlu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Dernek]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Komur]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Aydogmus]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kesiktas]]></surname>
<given-names><![CDATA[FN]]></given-names>
</name>
</person-group>
<source><![CDATA[Knee Surg Sports Traumatol Arthrosc]]></source>
<year>2017</year>
<volume>25</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>485-92</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Platelet-rich plasma why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Filardo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Kon]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Roffi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Di Matteo]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Merli]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Marcacci]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Knee Surg Sports Traumatol Arthrosc]]></source>
<year>2015</year>
<volume>23</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2459-74</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: Radiofrequency neurotomy of the genicular nerves or intra-articular injection?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sari]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Aydin]]></surname>
<given-names><![CDATA[ON]]></given-names>
</name>
<name>
<surname><![CDATA[Turan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Özlülerden]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Efe]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Kurt-Ömürlü]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Rheum Dis]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Long term effects of intra-articular botulinum toxin A for refractory joint pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahowald]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Singh]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Dykstra]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurotox Res]]></source>
<year>2006</year>
<volume>9</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>179-88</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
