<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462018000200106</article-id>
<article-id pub-id-type="doi">10.20986/resed.2017.3617/2017</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eficacia analgésica del sevoflurano tópico en heridas]]></article-title>
<article-title xml:lang="en"><![CDATA[Analgesic efficacy of topical sevoflurane on wounds]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gerónimo-Pardo]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortiñas-Sáenz]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Complejo Hospitalario Universitario Servicio de Anestesiología, Reanimación y Terapéutica del Dolor ]]></institution>
<addr-line><![CDATA[Albacete ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Torrecárdenas Servicio de Anestesiología, Reanimación y Terapéutica del Dolor Unidad del Dolor]]></institution>
<addr-line><![CDATA[Almería ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2018</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<fpage>106</fpage>
<lpage>111</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462018000200106&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462018000200106&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462018000200106&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El sevoflurano es un anestésico derivado halogenado del éter dietílico que se presenta como un líquido volátil. Es ampliamente utilizado por vía inhalatoria para la inducción y el mantenimiento de la anestesia general, pues su perfil de seguridad es muy bueno. Además de su acción hipnótica, diversas experiencias preclínicas muestran que el sevoflurano y otros derivados halogenados del éter producen un efecto analgésico/anestésico importante cuando son administrados en su formulación líquida directamente al sistema nervioso central, concretamente a la médula espinal, pero clásicamente se les considera carentes de efecto analgésico a nivel periférico. Sin embargo, en los últimos años se están comunicando experiencias clínicas en las que el sevoflurano produce un efecto analgésico importante sobre heridas dolorosas cuando es irrigado en su presentación líquida sobre el lecho de dichas heridas. Este efecto analgésico se caracteriza por instaurarse en escasos minutos, ser lo bastante intenso como para permitir el desbridamiento mecánico de las heridas, y extenderse por espacio de varias horas. Referido a efectos adversos, hasta ahora no ha sido comunicado ninguno a nivel sistémico, y el efecto local más frecuentemente referido por los pacientes es prurito leve y transitorio. Hasta ahora las comunicaciones clínicas se limitan a casos clínicos aislados y series de casos, y es obvio que se precisa la realización de los pertinentes ensayos clínicos para establecer adecuadamente su papel en el tratamiento analgésico de las heridas dolorosas. Pero mientras estos ensayos clínicos se realizan, el empleo fuera de indicación de sevoflurano irrigado tópicamente sobre el lecho de heridas dolorosas es una alternativa analgésica de rescate a tener en cuenta en aquellas heridas de dolor refractario a los tratamientos habituales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Sevoflurane is a halogenated anesthetic derived from diethyl ether, which is presented as a volatile liquid. Administered by inhalation, it is widely used for the induction and maintenance of general anesthesia, as its safety profile is very good. In addition to their hypnotic action, various preclinical experiences show that sevoflurane and other halogenated ether derivatives produce an important analgesic/anesthetic effect when administered in their liquid form directly to the central nervous system, specifically to the spinal cord. However, it is classically thought they lack analgesic effect at peripheral level. However, clinical experiences in which sevoflurane had an important analgesic effect on painful wounds when it was irrigated in its liquid presentation on the bed of such wounds have been reported in recent years. Such analgesic effect is characterized by being established in a few minutes, be intense enough to allow sharp debridement of the wounds, and last for several hours. Concerning adverse effects, it has been reported so far no case of systemic adverse events; only local adverse effects have been reported, the most frequently reported one being mild and transitory itching. For the moment, clinical communications are limited to isolated clinical cases and case series of patients; obviously, relevant clinical trials are required to adequately establish the role of topical sevoflurane in the analgesic treatment of painful wounds. But while conducting these clinical trials, the off-label use of topical sevoflurane irrigated on the bed of painful wounds may be an alternative option for the analgesic treatment of wounds with pain refractory to usual treatments.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Sevoflurane]]></kwd>
<kwd lng="en"><![CDATA[anesthetics inhalation]]></kwd>
<kwd lng="en"><![CDATA[administration topical]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="en"><![CDATA[analgesics]]></kwd>
<kwd lng="es"><![CDATA[Sevoflurano]]></kwd>
<kwd lng="es"><![CDATA[anestésicos por inhalación]]></kwd>
<kwd lng="es"><![CDATA[administración tópica]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
<kwd lng="es"><![CDATA[analgésicos]]></kwd>
</kwd-group>
</article-meta>
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