<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462018000300166</article-id>
<article-id pub-id-type="doi">10.20986/resed.2017.3620/2017</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La epigenética en el tratamiento del dolor]]></article-title>
<article-title xml:lang="en"><![CDATA[Epigenetics in the treatment of pain]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Toro]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bolivar]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Seijas]]></surname>
<given-names><![CDATA[M.E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rotondo]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Central de Venezuela (UCV) Hospital de Clínicas Caracas (HCC) Instituto Médico La Floresta (IMLF)]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Médico La Floresta  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Médico La Floresta  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Médico La Floresta  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Médico La Floresta  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>25</volume>
<numero>3</numero>
<fpage>166</fpage>
<lpage>169</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462018000300166&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462018000300166&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462018000300166&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La epigenética se refiere a los cambios en el ADN e histonas que no implican alteraciones en la secuencia de nucleótidos y modifican la estructura y condensación de la cromatina, afectando de esta manera la expresión génica y el fenotipo. Las modificaciones epigenéticas son metilación del ADN y modificaciones de histonas.  Objetivo:  Realizar una revisión de la literatura sobre la importancia de la epigenética en la fisiopatología y el tratamiento del dolor.  Materiales y métodos:  se hizo una revisión de la bibliografía sobre el concepto de epigenética, sus bases biológicas, impacto sobre el dolor y su relación con posibles tratamientos.  Resultados:  Los mecanismos epigenéticos han cobrado cada vez más importancia debido a la creciente asociación con enfermedades complejas y comunes, así como por su influencia en el dolor y sus posibles tratamientos.  Conclusiones:  La epigenética tiene una clara relación en el dolor, en sus bases fisiopatológicas y posibles tratamientos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Epigenetics refers to changes in DNA and histones that do not involve alterations in the nucleotide sequence and modify the structure and condensation of the chromatin, thus affecting gene expression and phenotype. Epigenetic modifications are DNA methylation and histone modifications.  Objective:  To carry out a review of the literature on the importance of Epigenetics in the pathophysiology and treatment of pain.  Materials and methods:  A review of the literature on the concept of epigenetics, its biological bases, the impact on pain and its relation to possible treatments.  Results:  Epigenetic mechanisms have become increasingly important due to the growing association with complex and common diseases, as well as their influence on pain and its possible treatments.  Conclusions:  Epigenetics has a clear relationship in pain, its pathophysiological bases and possible treatments.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Epigenetics]]></kwd>
<kwd lng="en"><![CDATA[DNA methylation]]></kwd>
<kwd lng="en"><![CDATA[histones]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="en"><![CDATA[treatment]]></kwd>
<kwd lng="es"><![CDATA[Epigenética]]></kwd>
<kwd lng="es"><![CDATA[metilación del ADN]]></kwd>
<kwd lng="es"><![CDATA[histonas]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
<kwd lng="es"><![CDATA[tratamiento]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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