<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462019000100052</article-id>
<article-id pub-id-type="doi">10.20986/resed.2018.3664/2018</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Oxytocin and chronic pain in humans]]></article-title>
<article-title xml:lang="es"><![CDATA[Oxitocina y dolor crónico en humanos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palacios-Espinosa]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Carvajal]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Botero-Meneses]]></surname>
<given-names><![CDATA[J. S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palacios-Sánchez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Rosario Escuela de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Rosario Escuela de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2019</year>
</pub-date>
<volume>26</volume>
<numero>1</numero>
<fpage>52</fpage>
<lpage>58</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462019000100052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462019000100052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462019000100052&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Oxytocin (OT) is a long known neuropeptide, and it's uses in clinical practice, mainly those regarding obstetrics have been thoroughly studied. However, there's been an increasing interest in identifying other roles OT plays in emotion, cognition, perception and higher cognitive processing. OT is also believed o have a mayor role in the physiology and physiopathology of pain. We have reviewed existent literature and current human studies on the relationship between OT and chronic pain. The present work compiles a significant number of research papers and may cast some light on a remarkably interesting and promising matter.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La oxitocina (OT) es un neuropéptido conocido desde hace mucho tiempo, y sus usos en la práctica clínica, principalmente los relacionados con la obstetricia, se han estudiado en múltiples ocasiones. Sin embargo, ha habido un creciente interés en la identificación de otros roles que la OT pudiera tener en la emoción, la cognición, la percepción y otras funciones cognitivas superiores. También se cree que la OT es de gran importancia en la fisiología y la fisiopatología del dolor. Hemos revisado la literatura existente y los estudios actuales en humanos sobre la relación entre la OT y el dolor crónico. El presente trabajo compila un número significativo de trabajos de investigación y pudiera arrojar alguna luz sobre un asunto sumamente interesante y prometedor.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Chronic pain]]></kwd>
<kwd lng="en"><![CDATA[oxytocin]]></kwd>
<kwd lng="en"><![CDATA[prosocial behavior]]></kwd>
<kwd lng="en"><![CDATA[emotion]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="es"><![CDATA[Dolor crónico]]></kwd>
<kwd lng="es"><![CDATA[oxitocina]]></kwd>
<kwd lng="es"><![CDATA[conducta prosocial]]></kwd>
<kwd lng="es"><![CDATA[emoción]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[OXT - A Multifunctional Analgesic for Chronic Deep Tissue Pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burel]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Timothy]]></surname>
<given-names><![CDATA[JN]]></given-names>
</name>
<name>
<surname><![CDATA[Meredith]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Pharm Des]]></source>
<year>2015</year>
<volume>21</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>906-13</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A brief history of OXT and its role in modulating psychostimulant effects]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carson]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Guastella]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[ER]]></given-names>
</name>
<name>
<surname><![CDATA[McGregor]]></surname>
<given-names><![CDATA[IS]]></given-names>
</name>
</person-group>
<source><![CDATA[J Psychopharmacol]]></source>
<year>2013</year>
<volume>27</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>231-47</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="">
<collab>AB NM</collab>
<source><![CDATA[Vincent du Vigneaud - Facts]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Anagelsic effect of intracerebroventricular (ICV) somatostatin-14 (SOM-14), arginine vasopressin (AVP) and OXT (OT) in a patient with terminal cancer pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Madrazo]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Franco-Bourland]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Leon]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Mena]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Pain]]></source>
<year>1987</year>
<volume>30</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>S142</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intrathecal administration of OXT induces analgesia in low back pain involving the endogenous opiate peptide system]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Spine]]></source>
<year>1994</year>
<volume>19</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>867-71</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Decreased pain sensitivity in man after treatment with superlow doses of OXT]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Uryvaev]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Petrov]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Bulletin of Experimental Biology and Medicine]]></source>
<year>1996</year>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The interaction between the OXT and pain modulation in headache patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
<name>
<surname><![CDATA[Yuan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[YJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Neuropeptides]]></source>
<year>2013</year>
<volume>47</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>93-7</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The effect of intranasal OXT administration on acute cold pressor pain a placebo-controlled, double-blind, within-participants crossover investigation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rash]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Campbell]]></surname>
<given-names><![CDATA[TS]]></given-names>
</name>
</person-group>
<source><![CDATA[Psychosom Med]]></source>
<year>2014</year>
<volume>76</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>422-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[OXT nasal spray in fibromyalgic patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mameli]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pisanu]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Sardo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Marchi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pili]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Carboni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Rheumatol Int]]></source>
<year>2014</year>
<volume>34</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1047-52</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Turk]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gatchel]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Psychological approaches to pain management]]></source>
<year>2002</year>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Review OXT and the modulation of pain experience: Implications for chronic pain management]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tracy]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Georgiou-Karistianis]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Giummarra]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Neuroscience and Biobehavioral Reviews]]></source>
<year>2015</year>
<volume>55</volume>
<page-range>53-67</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[OXT - A Multifunctional Analgesic for Chronic Deep Tissue Pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goodin]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ness]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Pharm Des]]></source>
<year>2015</year>
<volume>21</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>906-13</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Plasma OXT levels in female fibromyalgia syndrome patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anderberg]]></surname>
<given-names><![CDATA[UM]]></given-names>
</name>
<name>
<surname><![CDATA[Uvnas-Moberg]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Z Rheumatol]]></source>
<year>2000</year>
<volume>59</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>373-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Plasma OXT in children with recurrent abdominal pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alfven]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[J Pediatric Gastroenterol Nutr]]></source>
<year>2004</year>
<volume>38</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>513-7</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[OXT actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Condés-Lara]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Maie]]></surname>
<given-names><![CDATA[IAS]]></given-names>
</name>
<name>
<surname><![CDATA[Dickenson]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
</person-group>
<source><![CDATA[Brain Research]]></source>
<year>2005</year>
<volume>1045</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>124-33</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Successful Pain Management with Epidural OXT]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Condes-Lara]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Zayas-González]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Manzano-García]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cordova-Quiroz]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Granados-Mortera]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia-Cuevas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[CNS Neurosci Ther]]></source>
<year>2016</year>
<volume>22</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>532-4</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Depressed concentrations of OXT and cortisol in children with recurrent abdominal pain of non-organic origin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alfven]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Acta Paediatrica]]></source>
<year>1994</year>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of OXT and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Snozzi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Silani]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bird]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Petrovic]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Heinrichs]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Emotion]]></source>
<year>2008</year>
<volume>8</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>781-91</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[OXT increases thresholds of colonic visceral perception in patients with irritable bowel syndrome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Louvel]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Delvaux]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Felez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fioramonti]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bueno]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lazorthes]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Gut]]></source>
<year>1996</year>
<volume>39</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>741-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
