<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462019000200008</article-id>
<article-id pub-id-type="doi">10.20986/resed.2018.3695/2018</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dexmedetomidina como coadyuvante en bloqueos de nervio periférico]]></article-title>
<article-title xml:lang="en"><![CDATA[Dexmedetomidine as an adjuvant to peripheral nerve block]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas González]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Puerto Montt Unidad de Dolor Agudo Servicio Anestesia y Pabellón]]></institution>
<addr-line><![CDATA[Puerto Montt ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad San Sebastián Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Puerto Montt ]]></addr-line>
<country>Chile</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>26</volume>
<numero>2</numero>
<fpage>103</fpage>
<lpage>115</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462019000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462019000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462019000200008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: Dexmedetomidina (DEX) es un fármaco multifunción propuesto en los últimos años como coadyuvante para bloqueos regionales con anestésico local (AL). Objetivos: Evaluar las propiedades analgésicas de este &#945;-2 agonista al adicionarse a AL en diferentes abordajes de bloqueo de nervio periférico (anestesia regional), en términos de calidad de la analgesia obtenida y potenciales complicaciones asociadas.  Materiales y métodos: Se llevó a cabo una revisión narrativa, utilizando términos MeSH (inglés-español), con motores de búsqueda ampliamente conocidos (PUBMED, EMBASE, COCHRANE y LILACS), considerando los últimos 5 años a la fecha (entre otros filtros), analizando revisiones sistemáticas, metanálisis o ensayos clínicos que comparasen bloqueos regionales con AL de larga duración con/sin DEX perineural.  Resultados: En líneas generales, al utilizar este &#945;-2 agonista selectivo, la latencia del bloqueo disminuyó - 19,16 %, aumentó la duración de la analgesia + 60,79 % y bloqueo motor + 54,71 %; reduciendo además consumo de opioides - 49,54 % y anestésicos locales - 52,00%, lo cual se explicaría por un mecanismo de acción intrínseco a nivel perineural. Su asociación a depresión cardiovascular y sedación (ambas transitorias, reversibles y sin mayor repercusión clínica) es dosis-dependiente, recomendándose 0,5-1 µg/kg perineural (máximo 100 µg).  Conclusiones: En términos de riesgo-beneficio, DEX perineural mejora la calidad de la analgesia obtenida con mínimos efectos adversos asociados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Dexmedetomidine (DEX) is a multifunction drug proposed in recent years as an adjuvant for regional nerve blocks with local anesthetic (LA).  Objetives: to evaluate the analgesic properties of this &#945;-2 agonist when added to LA in different peripheral nerve block approaches (regional anesthesia), in terms of the quality of the analgesia obtained and potential associated complications.  Materials and methods: Narrative review, using MeSH terms (English-Spanish), widely-known search engines, considering the last 5 years to date (among other filters), analyzing systematic reviews, meta-analysis or clinical trials comparing nerve blocks with/without perineural DEX added to long-term LA.  Results: In general terms, it's observed with this selective &#945;-2 agonist, that the blockade latency decreases -19.16 %, increases analgesia duration + 60,79 % and motor blockade + 54,71 %; decreasing postoperative opioids - 49,54 % and LA consumption - 52,00 %, which would be explained by an intrinsic mechanism at perineural level. Its association with cardiovascular depression and sedation (both transient, reversible and without major clinical consequences) is dose-dependent, recommending 0,5-1 &#956;g/kg perineural (maximum 100 &#956;g).  Conclusions: In terms of risk-benefit, perineural DEX improves the quality of analgesia obtained with minimal associated adverse effects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dexmedetomidina]]></kwd>
<kwd lng="es"><![CDATA[anestésicos]]></kwd>
<kwd lng="es"><![CDATA[locales analgesia]]></kwd>
<kwd lng="es"><![CDATA[anestesia]]></kwd>
<kwd lng="es"><![CDATA[bloqueo nervio]]></kwd>
<kwd lng="en"><![CDATA[Dexmedetomidine]]></kwd>
<kwd lng="en"><![CDATA[anesthetics]]></kwd>
<kwd lng="en"><![CDATA[local analgesia]]></kwd>
<kwd lng="en"><![CDATA[anesthesia]]></kwd>
<kwd lng="en"><![CDATA[nerve block]]></kwd>
</kwd-group>
</article-meta>
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