<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462019000400009</article-id>
<article-id pub-id-type="doi">10.20986/resed.2019.3710/2018</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Antagonismo NMDA en el tratamiento de la cefalea en racimos]]></article-title>
<article-title xml:lang="en"><![CDATA[NMDA antagonism in the treatment of cluster headache]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Padilla del Rey]]></surname>
<given-names><![CDATA[M L]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benítez Jiménez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Canuel]]></surname>
<given-names><![CDATA[J F]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Alejo Marchante]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Universitario José María Morales Meseguer Servicio de Anestesiología, Reanimación y Terapéutica del Dolor Unidad del Dolor]]></institution>
<addr-line><![CDATA[Murcia ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Universitario José María Morales Meseguer Servicio de Anestesiología, Reanimación y Terapéutica del Dolor ]]></institution>
<addr-line><![CDATA[Murcia ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Université Laval Centro Hospitalario Universitario de Québec Unidad del Dolor]]></institution>
<addr-line><![CDATA[Québec ]]></addr-line>
<country>Canada</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Universitario del Vinalopó Servicio de Anestesiología, Reanimación y Terapéutica del Dolor Unidad del Dolor]]></institution>
<addr-line><![CDATA[Alicante ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>26</volume>
<numero>4</numero>
<fpage>247</fpage>
<lpage>250</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462019000400009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462019000400009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462019000400009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El tratamiento estándar de la cefalea en racimos consiste en un tratamiento abortivo con oxígeno, triptanes, alcaloides ergóticos y/o anestésico local nasal tópico durante los episodios agudos y un tratamiento preventivo, como infiltraciones con esteroides, antagonistas de los canales del calcio y litio. Aunque la fisiopatología exacta de la cefalea en racimos no se conoce bien, se han demostrado niveles reducidos de metabolitos de quinurenina, los cuales gozan de propiedades anti-NMDA (N-metil-D-aspartato). La ketamina y el magnesio, que tienen una potente actividad antagonista NMDA, se han usado en múltiples síndromes de dolor refractario. Describimos un caso de cefalea en racimos que no respondió al tratamiento estándar y se trató de forma efectiva con infusión intravenosa de magnesio y ketamina.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Standard treatment for cluster headache consists of abortive treatment with oxygen, triptans, ergot alkaloids and/or topical nasal local anesthetic during acute episodes and preventive treatment such as steroid injections, calcium channel blockers and lithium. Although the exact pathophysiology of cluster headache is not well understood, reduced serum levels of kynurenine metabolites with anti-NMDA (N-methyl-D-aspartate) properties have been demonstrated. Ketamine and magnesium, which both have potent anti-NMDA receptor activity, have been used in multiple refractory pain syndromes. We describe a case of cluster headache that was non-responsive to standard therapy and treated effectively with intravenous infusion of magnesium and ketamine.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[NMDA]]></kwd>
<kwd lng="es"><![CDATA[ketamina]]></kwd>
<kwd lng="es"><![CDATA[sulfato de magnesio]]></kwd>
<kwd lng="es"><![CDATA[cefalea en racimos]]></kwd>
<kwd lng="en"><![CDATA[NMDA]]></kwd>
<kwd lng="en"><![CDATA[ketamine]]></kwd>
<kwd lng="en"><![CDATA[magnesium sulfate]]></kwd>
<kwd lng="en"><![CDATA[cluster headache]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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