<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462021000100031</article-id>
<article-id pub-id-type="doi">10.20986/resed.2021.3876/2020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sensibilización central en la artrosis]]></article-title>
<article-title xml:lang="en"><![CDATA[Central sensitization in osteoarthritis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monfort Faure]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital del Mar Servicio de Reumatología ]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<fpage>31</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462021000100031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462021000100031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462021000100031&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El dolor de los pacientes con artrosis es un problema sociosanitario de primera magnitud y es el responsable de la importante limitación funcional y pérdida de calidad de vida en esta enfermedad. A pesar de haberse producido avances importantes en el conocimiento de los mecanismos fisiopatológicos del dolor, son muchos los interrogantes del dolor artrósico que todavía quedan por contestar. Uno de los aspectos menos estudiados del dolor crónico en la artrosis es el fenómeno de sensibilización central. La resonancia magnética nuclear funcional se ha mostrado como una técnica útil para el abordaje de este fenómeno. Diferentes estudios realizados a pacientes afectos de artrosis con distintos grados de sensibilización ponen de manifiesto que la incidencia de este fenómeno es elevada, que los pacientes sensibilizados y no sensibilizados muestran patrones diferentes en cuanto a la magnitud de la repuesta cerebral al dolor y que los patrones de conectividad difieren de una enfermedad a otra. Finalmente, en los pacientes candidatos a artroplastia de rodilla es importante evaluar el grado de sensibilización previo a la cirugía, puesto que son los pacientes con mayor grado de sensibilización los que presentarán evoluciones más tórpidas y mayores niveles de dolor posquirúrgico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Pain in patients with osteoarthritis is a social and health problem of great magnitude and is responsible for the significant functional limitation and loss of quality of life in this disease. Despite the important advances made in the knowledge of the pathophysiological mechanisms of pain, many questions about arthritic pain remain unanswered. One of the least studied aspects of chronic pain in osteoarthritis is the phenomenon of central sensitization. Functional Magnetic Resonance Imaging has shown to be a useful technique for addressing this phenomenon. Many studies carried out in patients with osteoarthritis with different degrees of sensitization show that the incidence of this phenomenon is high, that sensitized and non-sensitized patients show different patterns in terms of the magnitude of the cerebral response to pain and that the connectivity patterns differ from one disease to another. Finally, in patients who are candidates for knee arthroplasty, it is important to evaluate the degree of sensitization prior to surgery, since it is the patients with the highest degree of sensitization who will present more torpid evolutions and higher levels of post-surgical pain.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Osteoarthritis]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="en"><![CDATA[central sensitization]]></kwd>
<kwd lng="en"><![CDATA[functional magnetic resonance imaging]]></kwd>
<kwd lng="es"><![CDATA[Artrosis]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
<kwd lng="es"><![CDATA[sensibilización central]]></kwd>
<kwd lng="es"><![CDATA[resonancia magnética nuclear funcional]]></kwd>
</kwd-group>
</article-meta>
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