<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462021000100043</article-id>
<article-id pub-id-type="doi">10.20986/resed.2021.3864/2020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Revisión del tratamiento farmacológico del dolor secundario a artrosis con paracetamol, antinflamatorios no esteroideos clásicos (AINE) y los inhibidores selectivos de la ciclooxigenasa tipo 2 (COXIB)]]></article-title>
<article-title xml:lang="en"><![CDATA[Review of the pharmacological treatment of osteoarthritis pain with paracetamol, non-steroid anti-inflammatory (NSAIDSS) and selective cyclooxygenase-2 inhibitors (COXIB)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tornero Crespo]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montero Matamala]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Arnau de Vilanova Unidad del Dolor ]]></institution>
<addr-line><![CDATA[Lleida ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<fpage>43</fpage>
<lpage>48</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462021000100043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462021000100043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462021000100043&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En este monográfico se realiza una revisión de todos los aspectos relacionados con la artrosis para poder ofrecer al/la paciente el manejo más óptimo a la luz de la bibliografía disponible en el momento de redacción del mismo. En este artículo en concreto realizamos una revisión bibliográfica del tratamiento farmacológico de la artrosis con paracetamol, antinflamatorios no esteroideos clásicos (AINE) e inhibidores selectivos de la ciclooxigenasa tipo 2 (COXIB). Actualizamos los aspectos que más nos interesan desde un punto de vista clínico: eficacia, seguridad, comparativa dentro de estas opciones y con el resto de alternativas (intervencionistas u otras farmacológicas), para poder decidir los perfiles de pacientes en los que puede estar indicado este tipo de opciones farmacológicas, el momento evolutivo de su enfermedad o incluso el tiempo de mantenimiento de este tipo de fármacos. Para ello hemos realizado una revisión bibliográfica de los estudios que evalúan el efecto de estos fármacos analgésicos en la artrosis mediante una búsqueda electrónica utilizando Google Scholar, Medline/PubMed y la base de datos Cochrane de revisiones sistemáticas con el fin de recopilar la literatura disponible entre los años 2000 y 2020.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT In this monograph, a review of all aspects related to osteoarthritis is carried out in order to offer the patient with osteoarthritis the most optimal management in light of the bibliography available at the time of writing. In this specific article, we made a bibliographic review of the pharmacological treatment of osteoarthritis with paracetamol, classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase type 2 inhibitors (COXIBS). We update the aspects that interest us most from a clinical point of view: efficacy, safety, comparison within these options and with the rest of the alternatives (interventional or other pharmacological) for being able to decide the patient profiles in which this type is indicated of pharmacological options, the evolutionary moment of the disease or even the maintenance time of this type of drug. For reaching our objective, we have carried out a bibliographic review of the studies evaluating the effect of these analgesic drugs in osteoarthritis with an electronic search using Google Scholar, Medline/PubMed and the Cochrane database of systematic reviews to compile the available literature between the years 2000 and 2020.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Osteoarthritis]]></kwd>
<kwd lng="en"><![CDATA[paracetamol]]></kwd>
<kwd lng="en"><![CDATA[COXIB]]></kwd>
<kwd lng="en"><![CDATA[NSAIDS]]></kwd>
<kwd lng="en"><![CDATA[nonsteroidal anti-inflammatory drugs]]></kwd>
<kwd lng="en"><![CDATA[topical therapies]]></kwd>
<kwd lng="en"><![CDATA[cyclooxygenase-2 inhibitors.]]></kwd>
<kwd lng="es"><![CDATA[Artrosis]]></kwd>
<kwd lng="es"><![CDATA[paracetamol]]></kwd>
<kwd lng="es"><![CDATA[COXIB]]></kwd>
<kwd lng="es"><![CDATA[AINE]]></kwd>
<kwd lng="es"><![CDATA[antinflamatorios no esteroideos]]></kwd>
<kwd lng="es"><![CDATA[tratamiento tópico]]></kwd>
<kwd lng="es"><![CDATA[inhibidores de la ciclooxigenasa-2]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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