<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462021000100049</article-id>
<article-id pub-id-type="doi">10.20986/resed.2021.3855/2020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Opioides en la artrosis]]></article-title>
<article-title xml:lang="en"><![CDATA[Opioids in osteoarthritis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tornero Molina]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Universitario de Guadalajara Servicio de Reumatología ]]></institution>
<addr-line><![CDATA[Guadalajara ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Alcalá de Henares Departamento de Medicina y Especialidades Médicas ]]></institution>
<addr-line><![CDATA[Alcalá de Henares Madrid]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<fpage>49</fpage>
<lpage>56</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462021000100049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462021000100049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462021000100049&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La artrosis (OA) es una de las principales causas de discapacidad y dolor crónico. La OA es también responsable de un sustancial coste sociosanitario, tanto directo como por la pérdida de productividad laboral e invalidez. A pesar de numerosos esfuerzos, los tratamientos para mitigar el impacto de esta enfermedad no han alcanzado el umbral deseable de eficacia. Revisamos la utilidad de los opioides para la terapia del dolor de la OA. Los opioides proporcionan un alivio clínicamente poco relevante del dolor en el corto y medio plazo. Pueden mejorar la capacidad funcional a corto, pero no a medio plazo. La tolerabilidad a estos agentes es baja. Por lo tanto, los opioides juegan un papel limitado en el manejo del dolor por la OA en un reducido grupo de pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Osteoarthritis (OA) rank highly among global causes of disability and chronic pain. OA is also responsible for substantial health and societal costs, both directly and as a consequence of impaired work productivity and early retirement. Despite numerous efforts, treatments to paliate the impact of the disease have not reached a threshold of efficacy. We review the utility of opioids for the treatment of pain due to OA. Opioids provide no clinically relevant pain relief in the short- and intermediate-term for osteoarthritis pain. They provide a clinically relevant reduction in disability in the short but not in the intermediate term. The short- and intermediate-term tolerability of opioids is low. Therefore, opioids have a limited role in the management of OA pain in selected patients.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Osteoarthritis]]></kwd>
<kwd lng="en"><![CDATA[opioids]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="es"><![CDATA[Artrosis]]></kwd>
<kwd lng="es"><![CDATA[opioides]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
</kwd-group>
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