<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462021000100057</article-id>
<article-id pub-id-type="doi">10.20986/resed.2021.3863/2020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nuevas dianas terapéuticas en dolor por artrosis]]></article-title>
<article-title xml:lang="en"><![CDATA[New pharamcological targets for osteoarthritis induced pain]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Goicoechea García]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Rey Juan Carlos Facultad Ciencias de la Salud Departamento de Farmacología]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<fpage>57</fpage>
<lpage>63</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462021000100057&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462021000100057&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462021000100057&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La artrosis puede provocar la aparición de un proceso doloroso que es, hasta cierto punto, independiente de la patología, dado que su aparición y evolución no están directamente relacionadas con la progresión de la enfermedad. Estas características diferenciales hacen que el tratamiento del dolor por artrosis pueda tener y requerir un abordaje particular. La evidencia creciente del papel de la inflamación, sinovitis, en este dolor ha supuesto un aumento de la investigación destinada a identificar nuevas dianas farmacológicas relacionadas con este proceso. Entre las dianas que han ido descubriéndose a lo largo de los últimos años, pueden destacarse la PGE2 (liberada por los osteoblastos, y que aumentan la expresión de canales Nav1.8), determinados miARN y receptores TLR (activados por la sinovitis y que facilitan la transmisión de la señal nociceptiva) y el factor de crecimiento nervioso (NGF), que, mediante su unión al receptor trkA, contribuye a la sensibilización periférica y a la cronificación del dolor. Estas son solo algunas de las más prometedoras dianas farmacológicas para el tratamiento del dolor asociado a la artrosis que tal vez puedan, algún día, poner remedio al dolor de los pacientes aquejados de esta enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Osteoarthritis can be accompanied by a painful process that is mainly independent of the pathology, since its appearance and evolution are not directly related to the progression of the disease. These differential characteristics mean that the treatment of osteoarthritis pain may require a differential approach. The growing evidence of the role of inflammation, synovitis, in this osteoarthritis related-pain has led to an increase in research aimed at identifying new drug targets. Among those that have been identified in recent years, we can highlight PGE2 (released by osteoblasts, and that can increase the expression of Nav1.8 channels), certain miRNAs and TLR receptors (activated by synovitis and which facilitate the transmission of the nociceptive signal) and nerve growth factor (NGF), which, through its binding to the trkA receptor, contributes to peripheral sensitization and chronic pain. These are just some of the most promising drug targets for osteoarthritis pain that may one day be able to remedy the pain of osteoarthritis patients.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[NGF]]></kwd>
<kwd lng="en"><![CDATA[miRNA]]></kwd>
<kwd lng="en"><![CDATA[osteoarthritis]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="en"><![CDATA[rat]]></kwd>
<kwd lng="en"><![CDATA[review]]></kwd>
<kwd lng="es"><![CDATA[Artrosis]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
<kwd lng="es"><![CDATA[NGF]]></kwd>
<kwd lng="es"><![CDATA[nuevas dianas]]></kwd>
<kwd lng="es"><![CDATA[miRNA]]></kwd>
<kwd lng="es"><![CDATA[rata]]></kwd>
<kwd lng="es"><![CDATA[revisión]]></kwd>
</kwd-group>
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