<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462023000200008</article-id>
<article-id pub-id-type="doi">10.20986/resed.2023.4042/2022</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Farmacogenética y respuesta analgésica: hacia una medicina personalizada con análisis de las diferencias por sexo]]></article-title>
<article-title xml:lang="en"><![CDATA[Pharmacogenetics in analgesic response: towards a sex-differences personalized medicine]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orts-Jorquera]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muriel-Serrano]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peiró-Peiró]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Universitario de Alicante Servicio de Farmacología Clínica ]]></institution>
<addr-line><![CDATA[Alicante ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Investigación Sanitaria y Biomédica de Alicante Grupo de Neurofarmacología aplicada al dolor Plataforma de Farmacogenética aplicada a la investigación]]></institution>
<addr-line><![CDATA[Alicante ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Miguel Hernández Departamento de Farmacología Clínica, Pediatría y Química Orgánica Instituto de Bioingenería]]></institution>
<addr-line><![CDATA[Elche Alicante]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>30</volume>
<numero>2</numero>
<fpage>115</fpage>
<lpage>124</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462023000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462023000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462023000200008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El dolor crónico supone una epidemia silenciosa que afecta a 1 de cada 5 personas adultas en Europa. Este hecho convive con el abuso que realizan algunos pacientes de los medicamentos analgésicos, circunstancia que está limitando su prescripción en el dolor crónico no oncológico. El reto sería poder seleccionar las personas que, a priori, tendrían una mejor respuesta analgésica en base a una serie de condicionamientos intrínsecos. La presente revisión analiza las diferencias en base al sexo y a la presencia de ciertas variantes en los genes que codifican el receptor opioide mu (OPRM1), la enzima metabolizadora del citocromo CYP2D6 y la catecol-O-metiltransferasa (COMT) que degrada catecolaminas. El objetivo es suministrar potenciales elementos explicativos que puedan orientar al profesional clínico en la selección de una analgesia más personalizada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Chronic pain is a silent epidemic, affecting 1 in 5 adults in Europe. This fact coexists with the abuse of analgesic drugs by some patients, a circumstance that is limiting their prescription in chronic non-cancer pain. The challenge would be to be able to select the people who, a priori, would have a better analgesic response based on a series of intrinsic conditions. This review analyzes the differences based on sex and the presence of certain variants in the genes that encode the mu opioid receptor (OPRM1), the cytochrome metabolizing enzyme CYP2D6 and the catechol-O-methyltransferase (COMT) that degrades catecholamines. The objective is to provide potentially explanatory elements that can guide the clinical professional in the selection of a more personalized analgesia.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dolor crónico]]></kwd>
<kwd lng="es"><![CDATA[farmacogenética]]></kwd>
<kwd lng="es"><![CDATA[OPRM1]]></kwd>
<kwd lng="es"><![CDATA[CYP2D6]]></kwd>
<kwd lng="es"><![CDATA[diferencias por sexo]]></kwd>
<kwd lng="en"><![CDATA[Chronic pain]]></kwd>
<kwd lng="en"><![CDATA[pharmacogenetics]]></kwd>
<kwd lng="en"><![CDATA[OPRM1]]></kwd>
<kwd lng="en"><![CDATA[CYP2D6]]></kwd>
<kwd lng="en"><![CDATA[sex-differences]]></kwd>
</kwd-group>
</article-meta>
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