<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-8046</journal-id>
<journal-title><![CDATA[Revista de la Sociedad Española del Dolor]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Soc. Esp. Dolor]]></abbrev-journal-title>
<issn>1134-8046</issn>
<publisher>
<publisher-name><![CDATA[Inspira Network Group, S.L ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-80462023000400002</article-id>
<article-id pub-id-type="doi">10.20986/resed.2023.4025/2022</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Problemas y reacciones adversas relacionados con dipirona en Colombia]]></article-title>
<article-title xml:lang="en"><![CDATA[Problems and adverse reactions related to dipyrone in Colombia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Rueda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Martínez]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Molina Arteta]]></surname>
<given-names><![CDATA[BM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinilla-Monsalve]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Tratamiento e Investigación sobre el Cáncer Luis Carlos Sarmiento Angulo Unidad Funcional Asistencial de Soporte Oncológico ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Cancerología Servicio de Dolor y Cuidados Paliativos ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Bucaramanga Facultad de Estudios Tecnológicos ]]></institution>
<addr-line><![CDATA[Bucaramanga, Santander ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>30</volume>
<numero>4</numero>
<fpage>210</fpage>
<lpage>216</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462023000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-80462023000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-80462023000400002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El dolor agudo es altamente prevalente en el ámbito hospitalario y en el servicio de urgencias. La dipirona (metamizol) es un medicamento ampliamente utilizado para el tratamiento de síndromes dolorosos agudos, como el dolor postoperatorio. Principalmente, esta investigación busca caracterizar los problemas (PRM) y las reacciones adversas medicamentosas (RAM) más frecuentemente asociadas con la dipirona.  Materiales y métodos:  Este es un estudio de los registros de farmacovigilancia incluidos en la base de datos del Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) de Colombia. Se describieron los PRM y se calculó su incidencia. Además, se determinaron las características relacionadas con RAM no recuperables.  Resultados:  Se registraron 1833 prescripciones de dipirona que correspondían a 4021 problemas relacionados con los medicamentos (3868 RAM, 96,19 %). La incidencia de PRM por dipirona fue de 101 por cada 100.000 pacientes únicos prescritos. El 54,55 % de los pacientes fueron mujeres y la mediana de edad fue de 28 años (IQR 10-46). Las RAM más frecuentes fueron erupción cutánea (905; 24,78 %), prurito (561; 15,36 %) y urticaria (365; 9,99 %). 38 RAM comprometieron el sistema hematológico (0,98 %). Las RAM hematológicas en mujeres tuvieron una mayor probabilidad de no recuperación (OR 14,52 IQR 5,25-40,20; p = 0,000).  Conclusiones:  En Colombia, las RAM asociadas con dipirona más comunes comprometen la piel y anexos. A diferencia de la incidencia en pacientes de otras etnias, las RAM hematológicas son poco frecuentes, aunque sí se asocian con una menor probabilidad de recuperación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Acute pain is highly prevalent in The Hospital Settings and in the emergency department. Dipyrone (metamizole) is a widely used medication for acute pain syndromes, such as postoperative pain. This study aims to characterize the adverse drug reactions (ADRs) most frequently associated with dipyrone.  Materials and methods:  This is a study based on records in the Colombian database of the National Institute for Food and Drug Surveillance (INVIMA). Incidences were calculated and characteristics related to non-recoverable ADRs were determined.  Results:  A total of 1833 prescriptions of dipyrone were recorded, corresponding to 4021 medication-related problems (3868 ADRs, 96.19 %). The incidence of MRP due to dipyrone was 101 per 100,000 unique prescribed patients. Women accounted for 54.55% of the patients, and the median age was 28 years (IQR 10-46). The most frequent ADRs were skin rash (905; 24.78 %), pruritus (561; 15.36 %), and urticaria (365; 9.99 %). Thirty-eight ADRs affected the hematologic system (0.98 %). Hematologic ADRs in women had a higher probability of non-recovery (OR 14.52 IQR 5.25-40.20; p = 0.000).  Conclusions:  In Colombia, the most common ADRs associated with dipyrone affect the skin and its appendages. Unlike the incidence in patients of other ethnicities, hematologic ADRs are rare but are associated with a lower probability of recovery.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dolor]]></kwd>
<kwd lng="es"><![CDATA[dipirona]]></kwd>
<kwd lng="es"><![CDATA[metamizol]]></kwd>
<kwd lng="es"><![CDATA[reacción adversa]]></kwd>
<kwd lng="en"><![CDATA[Pain]]></kwd>
<kwd lng="en"><![CDATA[dipyrone]]></kwd>
<kwd lng="en"><![CDATA[methimazole]]></kwd>
<kwd lng="en"><![CDATA[adverse reaction]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raja]]></surname>
<given-names><![CDATA[SN]]></given-names>
</name>
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Finnerup]]></surname>
<given-names><![CDATA[NB]]></given-names>
</name>
<name>
<surname><![CDATA[Flor]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises]]></article-title>
<source><![CDATA[Pain]]></source>
<year>2020</year>
<volume>161</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1976-82</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hachimi-Idrissi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Coffey]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Hautz]]></surname>
<given-names><![CDATA[WE]]></given-names>
</name>
<name>
<surname><![CDATA[Leach]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sauter]]></surname>
<given-names><![CDATA[TC]]></given-names>
</name>
<name>
<surname><![CDATA[Sforzi]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Approaching acute pain in emergency settings: European Society for Emergency Medicine (EUSEM) guidelines-part 1: Assessment]]></article-title>
<source><![CDATA[Intern Emerg Med]]></source>
<year>2020</year>
<volume>15</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1125-39</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erazo]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Colmenares]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Suárez]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Mendivelso]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia y caracterización del dolor en pacientes hospitalizados]]></article-title>
<source><![CDATA[Revista de la Sociedad Española del Dolor]]></source>
<year>2015</year>
<volume>22</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>241-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoffmann]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Meinecke]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Freitag]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Glaeske]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Schulze]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Schmiemann]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Who gets dipyrone (metamizole) in Germany Prescribing by age, sex and region]]></article-title>
<source><![CDATA[J Clin Pharm Ther]]></source>
<year>2015</year>
<volume>40</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>285-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramacciotti]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[BGO]]></given-names>
</name>
<name>
<surname><![CDATA[Atallah]]></surname>
<given-names><![CDATA[AN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dipyrone for acute primary headaches]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2007</year>
<volume>2</volume>
<page-range>CD004842</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Derry]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Faura]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[McQuay]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Andrew Moore]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single dose dipyrone for acute postoperative pain]]></article-title>
<source><![CDATA[Cochrane Database of Systematic Reviews]]></source>
<year>2010</year>
<volume>9</volume>
<page-range>CD003227</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gaertner]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Stamer]]></surname>
<given-names><![CDATA[UM]]></given-names>
</name>
<name>
<surname><![CDATA[Remi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Voltz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bausewein]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Sabatowski]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice]]></article-title>
<source><![CDATA[Palliat Med]]></source>
<year>2017</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>26-34</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nikolova]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Petkova]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Tencheva]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Benbasat]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Voinikov]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Danchev]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole: A review profile of a well-known "forgotten" drug. Part II: Clinical profile]]></article-title>
<source><![CDATA[Biotechnology &amp; Biotechnological Equipment]]></source>
<year>2013</year>
<volume>27</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>3605-19</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="book">
<collab>Ministerio de Protección Social</collab>
<source><![CDATA[Resolución 1403 del 2007, por la cual se determina el modelo de gestión del servicio farmacéutico y se adopta el manual de condiciones esenciales y procedimientos y se dictan otras disposiciones]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Bogotá D.C. ]]></publisher-loc>
<publisher-name><![CDATA[Ministerio de Protección Social]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<collab>Instituto Nacional de Vigilancia de Medicamentos y Alimentos</collab>
<source><![CDATA[Circular 600-7758-15, por medio de la cual se establece el reporte en línea de eventos adversos a medicamentos]]></source>
<year>2015</year>
<publisher-loc><![CDATA[Bogotá D.C. ]]></publisher-loc>
<publisher-name><![CDATA[Instituto Nacional de Vigilancia de Medicamentos y Alimentos]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<source><![CDATA[ATC/DDD Index]]></source>
<year>2023</year>
<publisher-name><![CDATA[WHO]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<source><![CDATA[Estadísticas de Medicamentos, MEDCOL-STAT]]></source>
<year>2022</year>
<publisher-name><![CDATA[Ministerio de Salud de Colombia]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pinilla-Monsalve]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes-Rueda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pinilla-Monsalve]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Problemas y reacciones adversas relacionadas con analgésicos opioides en Colombia]]></article-title>
<source><![CDATA[Rev Neurol]]></source>
<year>2021</year>
<volume>73</volume>
<page-range>39</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frome]]></surname>
<given-names><![CDATA[EL]]></given-names>
</name>
<name>
<surname><![CDATA[Checkoway]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of Poisson regression models in estimating in estimating incidence rates and ratios]]></article-title>
<source><![CDATA[American Journal of Epidemiology]]></source>
<year>1985</year>
<volume>121</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>309-23</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González-Cárdenas]]></surname>
<given-names><![CDATA[VH]]></given-names>
</name>
<name>
<surname><![CDATA[Laverde-Gaona]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Cabarique-Serrano]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Chávez-Rojas]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Reina-Sierra]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Infante]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of the incidence of adverse events related to the administration of dipyrone]]></article-title>
<source><![CDATA[Colombian Journal of Anesthesiology]]></source>
<year>2018</year>
<volume>46</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>119-25</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Machado-Alba]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Cardona-Trejos]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Morales]]></surname>
<given-names><![CDATA[LV]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez-Ramírez]]></surname>
<given-names><![CDATA[LF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Identificación de reacciones adversas medicamentosas en pacientes tratados con dipirona en un hospital de tercer nivel]]></article-title>
<source><![CDATA[CES Medicina]]></source>
<year>2019</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>13-20</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Salazar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rosales]]></surname>
<given-names><![CDATA[SPL]]></given-names>
</name>
<name>
<surname><![CDATA[Rangel-Frausto]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Criollo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Archer-Dubon]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Orozco-Topete]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiology of adverse cutaneous drug reactions. A prospective study in hospitalized patients]]></article-title>
<source><![CDATA[Arch Med Res]]></source>
<year>2006</year>
<volume>37</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>899-902</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trautmann]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Brockow]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Stoevesandt]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole-induced reactions as a paradigm of drug hypersensitivity: Non-allergic reactions, anaphylaxis, and delayed-type allergy]]></article-title>
<source><![CDATA[Clin Exp Allergy]]></source>
<year>2020</year>
<volume>50</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1103-6</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blanca-López]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Sánchez]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Agúndez]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[García-Martin]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cornejo-García]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Allergic reactions to metamizole: Immediate and delayed responses]]></article-title>
<source><![CDATA[Int Arch Allergy Immunol]]></source>
<year>2016</year>
<volume>169</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>223-30</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoffmann]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bantel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jobski]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Agranulocytosis attributed to metamizole: An analysis of spontaneous reports in EudraVigilance 1985-2017]]></article-title>
<source><![CDATA[Basic &amp; Clinical Pharmacology &amp; Toxicology]]></source>
<year>2020</year>
<volume>126</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>116-25</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blaser]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
<name>
<surname><![CDATA[Tramonti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Egger]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Haschke]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Krähenbühl]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rätz Bravo]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hematological safety of metamizole: Retrospective analysis of WHO and Swiss spontaneous safety reports]]></article-title>
<source><![CDATA[Eur J Clin Pharmacol]]></source>
<year>2015</year>
<volume>71</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>209-17</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stammschulte]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Ludwig]]></surname>
<given-names><![CDATA[WD]]></given-names>
</name>
<name>
<surname><![CDATA[Mühlbauer]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Bronder]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Gundert-Remy]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole (dipyrone)-associated agranulocytosis An analysis of German spontaneous reports 1990-2012]]></article-title>
<source><![CDATA[European Journal of Clinical Pharmacology]]></source>
<year>2015</year>
<volume>71</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1129-38</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hedenmalm]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Spigset]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)]]></article-title>
<source><![CDATA[Eur J Clin Pharmacol]]></source>
<year>2002</year>
<volume>58</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>265-74</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole (dipyrone)-induced agranulocytosis: Does the risk vary according to ethnicity?]]></article-title>
<source><![CDATA[J Clin Pharm Ther]]></source>
<year>2019</year>
<volume>44</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>129-33</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vlahov]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bacracheva]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tontcheva]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Naumova]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Mavrudieva]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ilieva]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genetic factors and risk of agranulocytosis from metamizol]]></article-title>
<source><![CDATA[Pharmacogenetics]]></source>
<year>1996</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>67-72</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lutz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole (dipyrone) and the liver: A review of the literature]]></article-title>
<source><![CDATA[J Clin Pharmacol]]></source>
<year>2019</year>
<volume>59</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1433-42</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Collares]]></surname>
<given-names><![CDATA[EF]]></given-names>
</name>
<name>
<surname><![CDATA[Troncon]]></surname>
<given-names><![CDATA[LEA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of dipyrone on the digestive tract]]></article-title>
<source><![CDATA[Braz J Med Biol Res]]></source>
<year>2019</year>
<volume>52</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weber]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Benesic]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Neumann]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gerbes]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver injury associated with metamizole exposure: Features of an underestimated adverse event]]></article-title>
<source><![CDATA[Drug Saf]]></source>
<year>2021</year>
<volume>44</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>669-80</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
