<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1134-928X</journal-id>
<journal-title><![CDATA[Gerokomos]]></journal-title>
<abbrev-journal-title><![CDATA[Gerokomos]]></abbrev-journal-title>
<issn>1134-928X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Enfermería Geriátrica y Gerontológica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1134-928X2023000200008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alteraciones del sueño y demencia en población mayor. Revisión sistemática]]></article-title>
<article-title xml:lang="en"><![CDATA[Sleep disturbances and dementia in the elderly population. Systematic review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mérida-Raigón]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Plaza-Carmona]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Reina Sofía Unidad de Neumología ]]></institution>
<addr-line><![CDATA[Córdoba ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Complejo Asistencial Universitario de León Servicio Hospitalario de Urgencias ]]></institution>
<addr-line><![CDATA[León ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>34</volume>
<numero>2</numero>
<fpage>126</fpage>
<lpage>133</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-928X2023000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1134-928X2023000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1134-928X2023000200008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La demencia en la persona mayor es uno de los factores que más disminuye la calidad de vida, junto a las comorbilidades que conlleva, como las alteraciones del sueño. Sin embargo, numerosos estudios apuntan a una bidireccionalidad causal entre estos 2 factores. El objetivo del trabajo consiste en elaborar una revisión sistemática de las bases de datos disponibles acerca de la relación entre alteraciones en el sueño y la demencia.  Metodología: Las fuentes de búsqueda fueron PubMed, Scopus y Cochrane. Se siguió la estrategia de búsqueda &#8220;((Dementia) OR (&#8220;Alzheimer Disease&#8221;)) AND ((&#8220;Sleep Wake Disorders&#8221;) OR (circadia*) OR (&#8220;sleep disorders, intrinsic&#8221;) OR (&#8220;Sleep Disorders&#8221;) OR (&#8220;Circadian Rhythm&#8221;) OR (&#8220;Circadian Clocks&#8221;) OR (&#8220;sleep disorders, circadian rhythm&#8221;) OR (&#8220;circadian dysregulation&#8221;))&#8221;, se atendieron a los criterios de inclusión/exclusión y se extrajeron 35 artículos.  Resultados: La bibliografía revisada sustenta la relación de retroalimentación entre las alteraciones del sueño y la demencia. El beta-amiloide, característico de las placas y ovillos neurofibrilares en la enfermedad del Alzheimer, aumenta tras la privación de sueño, lo que, a su vez, suele generar acúmulo en el núcleo supraquiasmático, principal regulador del ciclo sueño-vigilia y de los ritmos circadianos.  Conclusiones: Las alteraciones del sueño son posibles predictores de la enfermedad del Alzheimer y, en su mayor parte, son un factor modificable de la gravedad y tiempo de inicio de la patología. Ambos se interrelacionan en una sinergia mutua.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Dementia in the elderly is one of the factors that most reduces the quality of life, together with the comorbidities that it entails, such as sleep disturbances. However, numerous studies point to a causal bidirectionality between these two factors. The aim of the study is to elaborate a systematic review of the available data base on the relationship between sleep disturbances and dementia.  Methodology: The search sources were PubMed, Scopus and Cochrane, following the search strategy &#8220;((Dementia) OR (&#8220; Alzheimer Disease &#8220;)) AND ((&#8220; Sleep Wake Disorders &#8220;) OR (circadia *) OR (&#8220; sleep disorders, intrinsic &#8220;) OR (&#8220; Sleep Disorders &#8220;) OR (&#8220;Circadian Rhythm&#8221;) OR (&#8220;Circadian Clocks&#8221;) OR (&#8220;sleep disorders, circadian rhythm&#8221;) OR (&#8220;circadian dysregulation&#8221;))&#8221;and according to the inclusion / exclusion criteria, 35 articles were extracted.  Results: The literature reviewed supports the feedback relationship between sleep disturbances and dementia. Amyloid-beta, characteristic of neurofibrillary plaques and tangles in Alzheimer disease, increases after sleep deprivation. Its accumulation is usually generated in the suprachiasmatic nucleus, the main regulator of the sleep-wake cycle and circadian rhythms.  Conclusions: Sleep disturbances are possible predictors of AD and, for the most part, a modifiable factor of the severity and time of onset of the pathology. Both are interrelated in a mutual synergy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Alzheimer]]></kwd>
<kwd lng="es"><![CDATA[demencia]]></kwd>
<kwd lng="es"><![CDATA[trastornos del sueño-vigilia]]></kwd>
<kwd lng="es"><![CDATA[trastornos del sueño del ritmo circadiano]]></kwd>
<kwd lng="es"><![CDATA[relojes circadianos]]></kwd>
<kwd lng="en"><![CDATA[Alzheimer disease]]></kwd>
<kwd lng="en"><![CDATA[dementia]]></kwd>
<kwd lng="en"><![CDATA[sleep wake disorders]]></kwd>
<kwd lng="en"><![CDATA[sleep disorders]]></kwd>
<kwd lng="en"><![CDATA[circadian rhythm]]></kwd>
<kwd lng="en"><![CDATA[circadian clocks]]></kwd>
</kwd-group>
</article-meta>
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