<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1137-6627</journal-id>
<journal-title><![CDATA[Anales del Sistema Sanitario de Navarra]]></journal-title>
<abbrev-journal-title><![CDATA[Anales Sis San Navarra]]></abbrev-journal-title>
<issn>1137-6627</issn>
<publisher>
<publisher-name><![CDATA[Gobierno de Navarra. Departamento de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1137-66272017000100119</article-id>
<article-id pub-id-type="doi">10.23938/assn.0011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores predictores del fracaso al tratamiento antibiótico empírico]]></article-title>
<article-title xml:lang="en"><![CDATA[Factors predicting failure in empirical antibiotic treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Lamberechts]]></surname>
<given-names><![CDATA[E.J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-del Castillo]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hormigo-Sánchez]]></surname>
<given-names><![CDATA[A.I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez-Orantos]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Candel]]></surname>
<given-names><![CDATA[F.J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Sánchez]]></surname>
<given-names><![CDATA[F.J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico San Carlos Servicio de Urgencias ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Fundación Jiménez Díaz Servicio de Medicina Interna-Geriatría ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Clínico San Carlos Servicio de Medicina Interna ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Clínico San Carlos Servicio de Microbiología Clínica ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>40</volume>
<numero>1</numero>
<fpage>119</fpage>
<lpage>130</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1137-66272017000100119&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1137-66272017000100119&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1137-66272017000100119&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las infecciones constituyen uno de las principales causas de morbimortalidad en la población. La elección del tratamiento empírico es una de las decisiones más habituales para cualquier médico responsable de su atención. Además, esta primera decisión puede tener consecuencias en cuanto al pronóstico del paciente o provocar un incremento de los costes asociados al proceso. Esta revisión intenta resumir cuáles son los aspectos que pueden provocar el fracaso al tratamiento antibiótico considerando aspectos microbiológicos, farmacológicos, del perfil del paciente y del control del foco infeccioso. Además, se establecen una serie de recomendaciones para minimizar este riesgo, desde el punto de vista de la precisión diagnóstica del foco y de la etiología, la estratificación adecuada de la gravedad del paciente, el conocimiento de los aspectos farmacocinéticos y farmacodinámicos de los antibióticos y el control, quirúrgico o mediante radiología intervencionista, del foco infeccioso.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Infections are one of the main causes of morbidity and mortality in the population. The choice of empirical treatment is one of the most common decisions facing the physician. This first decision has consequences in the prognosis of the patient and the costs associated with the process. This review attempts to summarize the aspects that can lead to failure of antibiotic treatment by considering microbiological and pharmacological aspects, patient profile and infectious focus control. In addition, a series of recommendations are established to minimize this risk, from the point of view of diagnostic accuracy, adequate severity stratification of the patient, knowledge of the pharmacokinetic and pharmacodynamic aspects of antibiotics and control of the infectious focus.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Antibiótico]]></kwd>
<kwd lng="es"><![CDATA[Adecuación]]></kwd>
<kwd lng="es"><![CDATA[Tratamiento inapropiado]]></kwd>
<kwd lng="es"><![CDATA[Infección]]></kwd>
<kwd lng="es"><![CDATA[Urgencias]]></kwd>
<kwd lng="en"><![CDATA[Antibiotic]]></kwd>
<kwd lng="en"><![CDATA[Adequacy]]></kwd>
<kwd lng="en"><![CDATA[Inappropriate treatment]]></kwd>
<kwd lng="en"><![CDATA[Infection]]></kwd>
<kwd lng="en"><![CDATA[Emergency]]></kwd>
</kwd-group>
</article-meta>
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