<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1139-7632</journal-id>
<journal-title><![CDATA[Pediatría Atención Primaria]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pediatr Aten Primaria]]></abbrev-journal-title>
<issn>1139-7632</issn>
<publisher>
<publisher-name><![CDATA[Asociación Española de Pediatría de Atención Primaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1139-76322017000100007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Posible síndrome de PHACE(S)]]></article-title>
<article-title xml:lang="en"><![CDATA[Possible PHACE(S) syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez Castillo]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moleón Rodríguez]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín Masot]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Salud Almanjayar  ]]></institution>
<addr-line><![CDATA[ Granada]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Salud Cartuja  ]]></institution>
<addr-line><![CDATA[ Granada]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Materno Infantil Virgen de las Nieves  ]]></institution>
<addr-line><![CDATA[ Granada]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2017</year>
</pub-date>
<volume>19</volume>
<numero>73</numero>
<fpage>51</fpage>
<lpage>56</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1139-76322017000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1139-76322017000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1139-76322017000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los hemangiomas infantiles son un motivo de consulta frecuente en Pediatría. El síndrome de PHACE(S) es un síndrome neurocutáneo a sospechar cuando se observan extensos hemangiomas cutáneos; en mayor grado si afectan al rostro. Es importante su diagnóstico, basado en criterios clínicos, para poder evaluar y tratar posibles complicaciones, algunas potencialmente letales. El adecuado manejo del paciente y sus necesidades requiere una intervención multidisciplinar, enfocada a disminuir el estrés e impedir la aparición de complicaciones del hemangioma y de las alteraciones asociadas al síndrome. Los &#946;-bloqueantes constituyen la primera línea en el tratamiento de los hemangiomas cutáneos, pero en estos pacientes, en caso de instaurarlos, es fundamental el despistaje previo de posibles malformaciones cerebrovasculares y cardiacas. Las alteraciones endocrinas son poco frecuentes, por lo que se precisa una alta sospecha diagnóstica para que no pasen desapercibidas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Infantile hemangiomas are a frequent reason for consultation in Pediatrics. When extensive cutaneous hemangiomas are observed and specially if they affect the face, we we should suspect a neurocutaneous disorder called PHACE(S) syndrome. Diagnosis must be based on clinical criteria in order to evaluate and treat possible complications that sometimes can be lethal. A proper management of the patients requires a multidisciplinary intervention, with the purpose of reducing stress and preventing the ocurrence of complications of the hemangioma and the disorders associated to the syndrome.Beta-blockers are employed as first-line treatment of cutaneous hemangiomas, but in these patients a prior screening of possible cerebrovascular and cardiac malformations is needed. Endocrine alterations are rare, so a high diagnostic suspicion is required to avoid going unnoticed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Anomalías cutáneas]]></kwd>
<kwd lng="es"><![CDATA[Accidente cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[Enfermedades arteriales cerebrales]]></kwd>
<kwd lng="es"><![CDATA[Infarto cerebral]]></kwd>
<kwd lng="es"><![CDATA[Dandy-Walker]]></kwd>
<kwd lng="es"><![CDATA[Hemangioma]]></kwd>
<kwd lng="en"><![CDATA[Skin abnormalities]]></kwd>
<kwd lng="en"><![CDATA[Stroke]]></kwd>
<kwd lng="en"><![CDATA[Cerebral arterial diseases]]></kwd>
<kwd lng="en"><![CDATA[Cerebral infarction]]></kwd>
<kwd lng="en"><![CDATA[Dandy-Walker]]></kwd>
<kwd lng="en"><![CDATA[Hemangioma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frieden]]></surname>
<given-names><![CDATA[IJ]]></given-names>
</name>
<name>
<surname><![CDATA[Reese]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PHACE. PHACE syndrome. The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities]]></article-title>
<source><![CDATA[Arch Dermatol]]></source>
<year>1996</year>
<volume>132</volume>
<page-range>307-11</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Metry]]></surname>
<given-names><![CDATA[DW]]></given-names>
</name>
<name>
<surname><![CDATA[Garzon]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Drolet]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Frommelt]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Haggstrom]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PHACE syndrome: current knowledge, future directions]]></article-title>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2009</year>
<volume>26</volume>
<page-range>381-98</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bhattacharya]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
<name>
<surname><![CDATA[Alvarez]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Rodesch]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Pongpech]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lasjaunias]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PHACES syndrome: a review of eight previously unreported cases with late arterial occlusions]]></article-title>
<source><![CDATA[Neuroradiology]]></source>
<year>2004</year>
<volume>46</volume>
<page-range>227-33</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Metry]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Heyer]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hess]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Garzon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Haggstrom]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Frommelt]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consensus statement on diagnostic criteria for PHACE syndrome]]></article-title>
<source><![CDATA[Pediatrics]]></source>
<year>2009</year>
<volume>124</volume>
<page-range>1447-56</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Recio-Rodríguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Martín Fernández-Mayoralas]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez de la Peña]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández-Jaén]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PHACES Syndrome (Pascual Castroviejo Type II): prenatal and postnatal magnetic resonance imaging]]></article-title>
<source><![CDATA[Radiologia]]></source>
<year>2013</year>
<volume>55</volume>
<page-range>537-40</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Haggstrom]]></surname>
<given-names><![CDATA[AN]]></given-names>
</name>
<name>
<surname><![CDATA[Drolet]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Baselga]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Chamlin]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Garzon]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Growth characteristics of infantile hemangiomas: implications for management]]></article-title>
<source><![CDATA[Pediatrics]]></source>
<year>2008</year>
<volume>122</volume>
<page-range>360-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Metry]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Frieden]]></surname>
<given-names><![CDATA[IJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hess]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Siegel]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Maheshwari]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Baselga]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Propranolol use in PHACE syndrome with cervical and intracranial arterial anomalies: collective experience in 32 infants]]></article-title>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2013</year>
<volume>30</volume>
<page-range>71-89</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chakkittakandiyil]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Phillips]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Frieden]]></surname>
<given-names><![CDATA[IJ]]></given-names>
</name>
<name>
<surname><![CDATA[Siegfried]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Lara-Corrales]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Lam]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study]]></article-title>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2012</year>
<volume>29</volume>
<page-range>28-31</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
