<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1139-7632</journal-id>
<journal-title><![CDATA[Pediatría Atención Primaria]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pediatr Aten Primaria]]></abbrev-journal-title>
<issn>1139-7632</issn>
<publisher>
<publisher-name><![CDATA[Asociación Española de Pediatría de Atención Primaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1139-76322019000100007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Perfil hormonal tiroideo poco frecuente. Síndrome de resistencia a hormonas tiroideas]]></article-title>
<article-title xml:lang="en"><![CDATA[Rare thyroid hormone profile. Thyroid hormone resistance syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marbán Calzón]]></surname>
<given-names><![CDATA[Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Jimeno]]></surname>
<given-names><![CDATA[Alicia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Bermejo]]></surname>
<given-names><![CDATA[Alba]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Belmonte Pintre]]></surname>
<given-names><![CDATA[Zaira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General La Mancha Centro Servicio de Endocrinología Pediátrica ]]></institution>
<addr-line><![CDATA[Alcázar de San Juan Ciudad Real]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Infanta Elena Servicio de Pediatría ]]></institution>
<addr-line><![CDATA[Valdemoro Madrid]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital General La Mancha Centro Servicio de Pediatría ]]></institution>
<addr-line><![CDATA[Alcázar de San Juan Ciudad Real]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>81</numero>
<fpage>e1</fpage>
<lpage>e5</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1139-76322019000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1139-76322019000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1139-76322019000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Solo puede asegurarse que la función tiroidea es normal cuando los niveles de hormona estimulante del tiroides y hormonas tiroideas tiroxina y triyodotironina libres son normales. Un patrón hormonal con tiroxina y triyodotironina libres elevadas y hormona estimulante del tiroides no suprimida es muy poco habitual, su principal causa es el síndrome de resistencia a hormonas tiroideas, entidad poco frecuente de causa genética que puede asociar síntomas de hipo- e hipertiroidismo y cuyo diagnóstico requiere un alto índice de sospecha. En niños la única o principal manifestación puede ser un trastorno por déficit de atención con hiperactividad. Presentamos una familia caracterizada a partir del diagnóstico inicial de dos hermanas gemelas a los 20 meses de edad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract It can only be ensured that thyroid function is normal when thyroid-stimulating hormone and free thyroid hormones thyroxine and triiodothyronine levels are normal. A hormonal pattern with elevated free thyroxine and triiodothyronine and unsuppressed thyroid-stimulating hormone is very rare, and its main cause is thyroid hormone resistance syndro¬me, a rare genetic entity that can associate symptoms of hypo and hyperthyroidism and whose diag¬nosis requires a high rate of suspicion. In children, the sole or main manifestation may be an attention deficit hyperactivity disorder. We present a family characterized by the initial diagnosis of twin sisters at 20 months of age.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hormonas tiroideas libres]]></kwd>
<kwd lng="es"><![CDATA[Resistencia a hormonas tiroideas]]></kwd>
<kwd lng="en"><![CDATA[Free thyroid hormones]]></kwd>
<kwd lng="en"><![CDATA[Thyroid hormone resistance]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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