<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1139-7632</journal-id>
<journal-title><![CDATA[Pediatría Atención Primaria]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pediatr Aten Primaria]]></abbrev-journal-title>
<issn>1139-7632</issn>
<publisher>
<publisher-name><![CDATA[Asociación Española de Pediatría de Atención Primaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1139-76322021000400020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La metformina podría ser un apoyo en el tratamiento de la obesidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Metformin could be of help in the treatment of obesity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Esparza-Olcina]]></surname>
<given-names><![CDATA[Mª Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Rodríguez]]></surname>
<given-names><![CDATA[Mª Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pediatra de Atención Primaria  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Salud Potes  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>23</volume>
<numero>92</numero>
<fpage>429</fpage>
<lpage>432</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1139-76322021000400020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1139-76322021000400020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1139-76322021000400020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Conclusiones de los autores del estudio: La metformina, asociada a intervenciones en el estilo de vida, puede tener un efecto favorable pequeño en el z-score del índice de masa corporal y en la resistencia a la insulina. Muestra un perfil de seguridad aceptable en niños y adolescentes con obesidad. La calidad de las pruebas disponibles es variable.  Comentario de los revisores: El tratamiento farmacológico de la obesidad podría ayudar a conseguir metas a corto y medio plazo, pero se desconoce su efecto a largo plazo. La utilización de la metformina, además de su modesto efecto sobre el índice de masa corporal, presenta efectos secundarios gastrointestinales frecuentes que pueden reducir el cumplimiento. Se podría valorar su uso individualizado en casos concretos de obesidad, sobre todo si presentan repercusión metabólica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Authors' conclusions: Metformin associated with lifestyle interventions may have a small favorable effect on BMI z-score and insulin resistance. It shows an acceptable safety profile in children and adolescents with obesity. The quality of the available evidence is variable.  Reviewers' commentary: Obesity drug therapy could help to achieve targets in the short and medium term, but the effect in the long term remains unknown. Metformin has a modest effect on BMI and produces frequent gastrointestinal adverse events that could reduce completion of treatments. Individual use of metformin could be proposed in specific obesity cases, especially if they present metabolic consequences.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Metformina]]></kwd>
<kwd lng="es"><![CDATA[Obesidad pediátrica]]></kwd>
<kwd lng="es"><![CDATA[Resistencia a la insulina]]></kwd>
<kwd lng="en"><![CDATA[Insulin resistance]]></kwd>
<kwd lng="en"><![CDATA[Metformin]]></kwd>
<kwd lng="en"><![CDATA[Pediatric obesity]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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