<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1139-7632</journal-id>
<journal-title><![CDATA[Pediatría Atención Primaria]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pediatr Aten Primaria]]></abbrev-journal-title>
<issn>1139-7632</issn>
<publisher>
<publisher-name><![CDATA[Asociación Española de Pediatría de Atención Primaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1139-76322022000100025</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hemofilia B, un sangrado atípicamente abundante durante una prueba rutinaria de un neonato]]></article-title>
<article-title xml:lang="en"><![CDATA[Hemophilia B, an atypically heavy bleeding during a routine newborn test]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibáñez Navarro]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zardoya Santos]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garbayo Solana]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roncal Pérez-Zabalza]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García López]]></surname>
<given-names><![CDATA[Estibaliz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,CS de Cintruénigo  ]]></institution>
<addr-line><![CDATA[Navarra ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,CS de Valtierra  ]]></institution>
<addr-line><![CDATA[Navarra ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,CS de Cintruénigo  ]]></institution>
<addr-line><![CDATA[Navarra ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,CS de Cintruénigo  ]]></institution>
<addr-line><![CDATA[Navarra ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>24</volume>
<numero>93</numero>
<fpage>e129</fpage>
<lpage>e131</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1139-76322022000100025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1139-76322022000100025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1139-76322022000100025&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La hemofilia B es un trastorno hematológico producido por el déficit del factor IX. Aunque generalmente se diagnostica cuando el lactante inicia el gateo o deambulación en forma de hemartros o hemorragias musculares, en este caso el debut es a los 3 días de vida, con un sangrado abundante atípico durante una prueba de rutina. La exploración y pruebas complementarias (hemograma, coagulación, ecografías de partes blandas y grandes articulaciones) no revelaron datos de gravedad. El factor IX, que determina la gravedad, pasó del 1% a un 3% en 24 horas por lo que no precisó de tratamiento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Hemophilia B is a blood disorder caused by a deficiency of factor IX. Although it is usually diagnosed when the infant starts crawling or walking like hemarthroses or muscle bleeds, in this case the debut is at 3 days of age in the face of heavy atypical bleeding during a routine test. Examination and further testing (blood count, coagulation, ultrasound of soft tissue and large joints) revealed no data on complications. Factor IX, which determines the severity, was increased from 1% to 3% in 24 hours and therefore didn't require treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedades genéticas]]></kwd>
<kwd lng="es"><![CDATA[Enfermedades hematológicas]]></kwd>
<kwd lng="es"><![CDATA[Factor IX]]></kwd>
<kwd lng="es"><![CDATA[Hemofilia B]]></kwd>
<kwd lng="es"><![CDATA[Trastornos de la coagulación sanguínea]]></kwd>
<kwd lng="en"><![CDATA[Blood coagulation disorders]]></kwd>
<kwd lng="en"><![CDATA[Factor IX]]></kwd>
<kwd lng="en"><![CDATA[Genetic diseases]]></kwd>
<kwd lng="en"><![CDATA[Hematologic diseases]]></kwd>
<kwd lng="en"><![CDATA[Hemophilia B]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alshaikhli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rokkam]]></surname>
<given-names><![CDATA[VR]]></given-names>
</name>
</person-group>
<source><![CDATA[Hemophilia B]]></source>
<year></year>
<publisher-loc><![CDATA[Treasure Island ]]></publisher-loc>
<publisher-name><![CDATA[StatPearls]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goodeve]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemophilia B: molecular pathogenesis and mutation analysis]]></article-title>
<source><![CDATA[J Thromb Haemost]]></source>
<year>2015</year>
<volume>13</volume>
<page-range>1184-95</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Konkle]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Huston]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Nakaya Fletcher]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemophilia B]]></article-title>
<source><![CDATA[GeneReviews Island]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Current challenges in the management of hemophilia]]></article-title>
<source><![CDATA[Am J Manag Care]]></source>
<year>2015</year>
<volume>21</volume>
<page-range>S112-22</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miesbach]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Schwäble]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Müller]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Seifried]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment Options in Hemophilia]]></article-title>
<source><![CDATA[Dtsch Arztebl Int]]></source>
<year>2019</year>
<numero>116</numero>
<issue>116</issue>
<page-range>791-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Djambas Khayat]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Once-weekly prophylactic dosing of recombinant factor IX improves adherence in hemophilia B]]></article-title>
<source><![CDATA[J Blood Med]]></source>
<year>2016</year>
<volume>7</volume>
<page-range>275-82</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ljung]]></surname>
<given-names><![CDATA[RCR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevention and Management of Bleeding Episodes in Children with Hemophilia]]></article-title>
<source><![CDATA[Paediatr Drugs]]></source>
<year>2018</year>
<volume>20</volume>
<page-range>455-64</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zaliuniene]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Peciuliene]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Brukiene]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Aleksejuniene]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemophilia and oral health]]></article-title>
<source><![CDATA[Stomatologija]]></source>
<year>2014</year>
<volume>16</volume>
<page-range>127-31</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
