<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1139-7632</journal-id>
<journal-title><![CDATA[Pediatría Atención Primaria]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pediatr Aten Primaria]]></abbrev-journal-title>
<issn>1139-7632</issn>
<publisher>
<publisher-name><![CDATA[Asociación Española de Pediatría de Atención Primaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1139-76322024000300013</article-id>
<article-id pub-id-type="doi">10.60147/c1bc667b</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[¿Pero esto qué es? ¿El ácido valproico es el culpable?]]></article-title>
<article-title xml:lang="en"><![CDATA[But what is this? Is valproic acid a potential culprit?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Labjaková]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díez Román]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carabaño Aguado]]></surname>
<given-names><![CDATA[Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario 12 de Octubre Servicio de Pediatría ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario 12 de Octubre Servicio de Radiodiagnóstico ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario 12 de Octubre Servicio de Pediatría Sección de Gastroenterología, Hepatología y Nutrición Infantil]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<volume>26</volume>
<numero>103</numero>
<fpage>307</fpage>
<lpage>310</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1139-76322024000300013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1139-76322024000300013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1139-76322024000300013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[ Resumen La pancreatitis aguda en la edad pediátrica se debe a etiología muy variada, siendo una de ellas la toxicidad por fármacos. Aunque la lista de fármacos que pueden causar pancreatitis aguda es muy amplia, en la literatura se relaciona con más evidencia con el uso de 6-mercaptopurina, azatioprina, los inhibidores de la enzima convertidora de angiotensina (IECA), metronidazol, asparaginasa, paracetamol y el ácido valproico. El ácido valproico es un medicamento frecuentemente utilizado en Pediatría. A pesar de que la mayoría de los efectos adversos asociados al uso de este medicamento son benignos, puede asociarse a reacciones adversas graves. Las más frecuentemente descritas son: hepatotoxicidad, teratogenicidad y pancreatitis aguda. La pancreatitis aguda inducida por ácido valproico se debe a una reacción idiosincrásica, que no depende de los niveles del fármaco en la sangre y puede ocurrir en cualquier momento tras el inicio del tratamiento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ Abstract Acute pancreatitis in children can result from a wide variety of etiologies, one of them being drug toxicity. Although the list of medications associated with acute pancreatitis is extensive, the literature provides stronger evidence for drugs such as 6-mercaptopurine, azathioprine, angiotensin-converting enzyme (ACE) inhibitors, metronidazole, asparaginase, acetaminophen and valproic acid. Valproic acid is a drug frequently used in pediatrics. Although most side effects associated with its use are benign, it may also be linked to severe adverse reactions. The most commonly reported include hepatotoxicity, teratogenicity, and acute pancreatitis. Valproic acid-induced acute pancreatitis is thought to occur due to an idiosyncratic reaction, which is independent of drug levels in the blood and can happen at any time during treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ácido valproico]]></kwd>
<kwd lng="es"><![CDATA[Pancreatitis aguda]]></kwd>
<kwd lng="es"><![CDATA[Reacción adversa]]></kwd>
<kwd lng="en"><![CDATA[Acute pancreatitis]]></kwd>
<kwd lng="en"><![CDATA[Adverse event]]></kwd>
<kwd lng="en"><![CDATA[Valproic acid]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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</back>
</article>
