<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1699-695X</journal-id>
<journal-title><![CDATA[Revista Clínica de Medicina de Familia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Clin Med Fam]]></abbrev-journal-title>
<issn>1699-695X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Medicina de Familia y Comunitaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1699-695X2020000200004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características epidemiológicas del hipotiroidismo en un área del sur de España (Sevilla)]]></article-title>
<article-title xml:lang="en"><![CDATA[Epidemiological characteristics of hypothyroidism in an área in southern Spain (Seville)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mohedano López]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sanchís Osuna]]></surname>
<given-names><![CDATA[Luis Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Vargas]]></surname>
<given-names><![CDATA[José Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez Hurtado]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luque Romero]]></surname>
<given-names><![CDATA[Luis Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Atención Primaria Bormujos  ]]></institution>
<addr-line><![CDATA[Sevilla ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Atención Primaria Castilleja de la Cuesta  ]]></institution>
<addr-line><![CDATA[Sevilla ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidad de Investigación Distrito Aljarafe - Sevilla Norte  ]]></institution>
<addr-line><![CDATA[Mairena del Aljarafe Sevilla]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>13</volume>
<numero>2</numero>
<fpage>123</fpage>
<lpage>130</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1699-695X2020000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1699-695X2020000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1699-695X2020000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: Determinar la incidencia y prevalencia del hipotiroidismo, estratificándolas por sexo y edad; así como el coste por dosis diaria definida (cDDD) de levotiroxina.  Diseño: Estudio observacional, descriptivo, longitudinal y retrospectivo.  Emplazamiento: Área Sanitaria Aljarafe-Sevilla Norte.  Participantes: Pacientes de cualquier edad y sexo residentes en este Área Sanitaria, que tuvieran prescrita levotiroxina en los años 2015-2017 y al menos dos analíticas consecutivas para el control tiroideo entre 2014-2017.  Mediciones Principales: Se determinaron los valores de tirotropina, tiroxina y anticuerpos antiperoxidasa tiroidea facilitados por la Unidad de Laboratorio del Hospital San Juan de Dios. También los datos de prescripción de levotiroxina y su coste por dosis diaria definida, aportados por la Unidad de Farmacia del Distrito Sanitario Sevilla-Norte. Se consideró el coste del valor medio por dosis diaria definida de levotiroxina.  Resultados: Se analizaron 45.224 analíticas tiroideas. El 78,4 % pertenecían a mujeres. La edad media fue 49,04 (DE: 21,24) años. La prevalencia (2017) de hipotiroidismo fue del 5,54 % (IC 95 %: 5,45-5,62), la incidencia acumulada de hipotiroidismo clínico fue 2,67 casos/1.000 personas-año (IC 95 %: 2,67-2,68) y del subclínico 52,04 casos/1.000personas-año (IC 95 %: 52,01-52,06). El coste medio anual asociado al consumo de levotiroxina fue de 153.081,13 &#8364; (DE:12.662,03) (IC 95 %:152.964,43-153.197,83).  Conclusiones: El presente estudio establece los primeros datos de incidencia acumulada de hipotiroidismo en un área de España y presenta una prevalencia mayor en comparación con la mayoría de estudios previos. Asimismo, muestra el coste por dosis diaria definida (cDDD) de levotiroxina, que tuvo una tendencia ascendente en el período 2015-2017.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Objective: To determine the incidence and prevalence of hypothyroidism, stratifying by sex and age, as well as the cost per defined daily dose (cDDD) of levothyroxine.  Design: Observational, descriptive, longitudinal, retrospective study.  Setting: Aljarafe-Sevilla Norte Health Area.  Participants: Patients of any age and either sex living in this Health Area, who were treated with levothyroxine in 2015-2017 and who had at least two consecutive blood tests for thyroid control between 2014-2017  Main measures: Levels of thyrotropin, thyroxine, and anti-thyroid peroxidase antibodies were determined, provided by the Laboratory Unit of the Hospital San Juan de Dios. Data on levothyroxine prescription and its cost per defined daily dose were also determined, provided by the Pharmacy Unit of the Distrito Sanitario Sevilla-Norte. We considered the cost of the mean value per defined daily dose of levothyroxine.  Results: 45,224 thyroid tests were analysed. 78.4% belonged to women. The average age was 49.04 (SD: 21.24). The prevalence (2017) of hypothyroidism was 5.54% (95% CI: 5.45-5.62), the cumulative incidence of clinical hypothyroidism was 2.67 cases/1000 persons-year (95% CI: 2.67-2.68) and of subclinical hypothyroidism was 52.04 cases/1000 persons-year (95% CI: 52.01-52.06). The annual average cost associated with levothyroxine use was 153,081.13 &#8364; (SD: 12,662.03) (95% CI: 152,964.43-153,197.83).  Conclusions: This study establishes the first data on cumulative incidence of hypothyroidism in a Spanish area and presents a higher prevalence compared to most of the previous studies. Likewise, it shows a cost per defined daily dose (cDDD) of levothyroxine which followed an upward trend in the period 2015-2017.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hipotiroidismo]]></kwd>
<kwd lng="es"><![CDATA[Incidencia]]></kwd>
<kwd lng="es"><![CDATA[Prevalencia]]></kwd>
<kwd lng="es"><![CDATA[Atención Primaria]]></kwd>
<kwd lng="en"><![CDATA[Hypothyroidism]]></kwd>
<kwd lng="en"><![CDATA[Incidence]]></kwd>
<kwd lng="en"><![CDATA[Prevalence]]></kwd>
<kwd lng="en"><![CDATA[Primary care]]></kwd>
</kwd-group>
</article-meta>
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