<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1886-5887</journal-id>
<journal-title><![CDATA[Revista de Bioética y Derecho]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Bioética y Derecho]]></abbrev-journal-title>
<issn>1886-5887</issn>
<publisher>
<publisher-name><![CDATA[Observatori de Bioètica i Dret - Cátedra UNESCO de Bioética]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1886-58872019000300003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Interrogantes y retos actuales de la edición genética]]></article-title>
<article-title xml:lang="en"><![CDATA[Open questions and challenges of gene editing]]></article-title>
<article-title xml:lang="ca"><![CDATA[Interrogants i reptes actuals de l'edició genètica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marfany]]></surname>
<given-names><![CDATA[Gemma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universitat de Barcelona  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Investigación Biomédica en Red de Enfermedades Raras  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Barcelona Instituto de Biomedicina Institut de Recerca Sant Joan de Déu]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<numero>47</numero>
<fpage>17</fpage>
<lpage>31</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1886-58872019000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1886-58872019000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1886-58872019000300003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La tecnología de la edición génica por CRISPR ha revolucionado tanto la investigación en biotecnología como en biomedicina. Esta técnica tan poderosa y versátil permite editar los genes de cualquier especie a la carta. A pesar de su potencia y efectividad, quedan muchas cuestiones para resolver y controlar su resultado final, particularmente en las aplicaciones sobre el genoma de los seres humanos. En este artículo se plantean tanto los puntos fuertes y puntos débiles de la técnica, como otras cuestiones abiertas sobre la edición génica, sobre si debe dirigirse a la terapia o a la mejora, si la modificación debe constreñirse a células somáticas o también a editar a embriones, modificando el genoma de los seres humanos del futuro.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Gene editing using CRISPR has completely revolutionized the research in biotechnology and biomedicine. This powerful and versatile technique enables the precise edition of genes from any organism. Even though the technique is so effective and amenable, many questions remain to be solved before the final genetic outcome can be fully controlled, particularly in its uses on the human genome. In this article, I discuss the current strengths and weaknesses of the technique. I also pose other open questions on gene editing, such as whether it should be used for either therapy or genetic enhancement, and whether it should be used only on somatic cells or also for embryo gene editing, the latter resulting in the modification of future human beings.]]></p></abstract>
<abstract abstract-type="short" xml:lang="ca"><p><![CDATA[Resum La tecnologia de l'edició gènica mitjançant CRISPR ha revolucionat tant la recerca en biotecnologia com en biomedicina. Aquesta tècnica tan poderosa i versàtil permet editar els gens de qualsevol espècie a la carta. Malgrat la seva potència i efectivitat, queden moltes qüestions per resoldre i controlar el seu resultat final, particularment en les aplicacions sobre el genoma dels éssers humans. En aquest article es plantegen els punts forts i els punts febles de la tècnica, així com altres qüestions obertes sobre l'edició gènica, si ha de dirigir-se a la teràpia o a la millora, si la modificació ha de constrènyer-se a cèl·lules somàtiques o també es poden editar en embrions, modificant el genoma dels éssers humans del futur.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[edición génica]]></kwd>
<kwd lng="es"><![CDATA[modificación genética]]></kwd>
<kwd lng="es"><![CDATA[células germinales]]></kwd>
<kwd lng="es"><![CDATA[terapia génica]]></kwd>
<kwd lng="es"><![CDATA[impulso génico]]></kwd>
<kwd lng="en"><![CDATA[gene editing]]></kwd>
<kwd lng="en"><![CDATA[genetic modification]]></kwd>
<kwd lng="en"><![CDATA[germinal cells]]></kwd>
<kwd lng="en"><![CDATA[gene therapy]]></kwd>
<kwd lng="en"><![CDATA[gene drive]]></kwd>
<kwd lng="ca"><![CDATA[edició gènica]]></kwd>
<kwd lng="ca"><![CDATA[modificació genètica]]></kwd>
<kwd lng="ca"><![CDATA[cèl·lules germinals]]></kwd>
<kwd lng="ca"><![CDATA[teràpia gènica]]></kwd>
<kwd lng="ca"><![CDATA[impuls gènic]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mojica]]></surname>
<given-names><![CDATA[FJM]]></given-names>
</name>
<name>
<surname><![CDATA[Montoliu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends in Microbiology]]></source>
<year>2016</year>
<volume>24</volume>
<page-range>811-20</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR/Cas9 in Genome Editing and Beyond]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[La-Russa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[QS]]></given-names>
</name>
</person-group>
<source><![CDATA[Annual Reviews in Biochemistry]]></source>
<year>2016</year>
<volume>85</volume>
<page-range>227-64</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR creates wave of exotic model organisms]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reardon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2019</year>
<volume>568</volume>
<page-range>441-2</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Collateral damage and CRISPR genome editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[PLOS Genetics]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The new frontier of genome engineering with CRISPR-Cas9]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doudna]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Charpentier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2014</year>
<volume>346</volume>
<page-range>1077</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="">
<source><![CDATA[FDA Statement Commissioner Scott Gottlieb, M.D., and Deputy Commissioner Anna Abram on the FDA's new plan to advance plant, animal biotechnology innovation]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="">
<collab>European Commission</collab>
<source><![CDATA[European Commission Scientific Advisors Statement on the regulation of gene editing]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Efficient generation of myostatin knock-out sheep using CRISPR-Cas9 technology and microinjection in zygotes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Crispo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS One]]></source>
<year>2015</year>
<volume>10</volume>
<page-range>e0136690</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Use the patent system to regulate gene editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parthasarathy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2018</year>
<volume>562</volume>
<page-range>486-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Concerning RNA-guided gene drives for the alteration of wild populations]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Esvelt]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
</person-group>
<source><![CDATA[eLife]]></source>
<year>2014</year>
<volume>3</volume>
<page-range>e03401</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Regulate gene editing in wild animals]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lunshof]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2015</year>
<volume>521</volume>
<page-range>127</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR: la edición genética aún no está preparada para tratar a pacientes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Montoliu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[The Conversation]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The Future of Gene Editing -Toward Scientific and Social Consensus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosenbaum]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[New England Journal of Medicine]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tomorrow's children]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Check-Hayden]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2019</year>
<volume>530</volume>
<page-range>402-5</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lessard]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Proceedings of the National Academy of Sciences (USA)]]></source>
<year>2017</year>
<volume>114</volume>
<page-range>E11257-66</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Highly efficient therapeutic gene editing of human hematopoietic stem cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature Medicine]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Novartis's pricing might be tested with costly eye therapy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Thomson Reuters News]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Public views on gene editing and its uses]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gaskell]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2017</year>
<volume>35</volume>
<page-range>1021-102</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Brave New Genome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lander]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
</person-group>
<source><![CDATA[New England Journal of Medicine]]></source>
<year>2015</year>
<volume>373</volume>
<page-range>5-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[I prefer a child with...: designer babies, another controversial patent in the arena of direct-to-consumer genomics]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sterckx]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Genetics in Medicine]]></source>
<year>2013</year>
<volume>15</volume>
<page-range>923-4</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Biohackers gear up for genome editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ledford]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2015</year>
<volume>524</volume>
<page-range>398-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[FDA warns public of dangers of DIY gene therapy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smalley]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2018</year>
<volume>36</volume>
<page-range>119-20</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Shock greets claim of CRISPR-edited babies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Normille]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2018</year>
<volume>362</volume>
<page-range>978-9</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Rogues and Regulation of Germline Editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alta-Charo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[New England Journal of Medicine]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR-baby scientist fails to satisfy his critics]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cyranoski]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2018</year>
<volume>564</volume>
<page-range>13-4</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[What's next for CRISPR babies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cyranoski]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2019</year>
<volume>566</volume>
<page-range>440-2</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[China sprints ahead in CRISPR therapy race]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Normille]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2017</year>
<volume>358</volume>
<page-range>20-1</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Don't edit the human germ line]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lanphier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2015</year>
<volume>519</volume>
<page-range>410-1</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Adopt a moratorium on heritable genome editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lander]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2019</year>
<volume>567</volume>
<page-range>165-8</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santaló]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Casado]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Document sobre bioètica i edició genòmica en humans]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Edicions UB ]]></publisher-loc>
<publisher-name><![CDATA[Barcleona]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Gene Editing in Humans: Towards a Global and Inclusive Debate for Responsible Research]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[LECUONA]]></surname>
<given-names><![CDATA[I de]]></given-names>
</name>
</person-group>
<source><![CDATA[Yale Journal of Biology and Medicine]]></source>
<year>2017</year>
<volume>90</volume>
<page-range>673-81</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[One small edit for humans, one giant edit for humankind? Points and questions to consider for a responsible way forward for gene editing in humans]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
</person-group>
<source><![CDATA[European Journal of Human Genetics]]></source>
<year>2017</year>
<volume>26</volume>
<page-range>1-11</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[ARRIGE Arrives: Toward the Responsible Use of Genome Editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Montoliu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[The CRISPR Journal]]></source>
<year>2018</year>
<volume>1</volume>
<page-range>128-9</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="">
<collab>Nuffield Council of Bioethics</collab>
<source><![CDATA[Genome editing and human reproduction]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The illusion of control in germline-engineering policy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[König]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2017</year>
<volume>35</volume>
<page-range>502-6</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Savulescu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genetic interventions and the ethics of enhancement of human beings]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Steinbock]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[The Oxford Handbook of Bioethics]]></source>
<year>2009</year>
<page-range>516-35</page-range><publisher-loc><![CDATA[Oxford ]]></publisher-loc>
<publisher-name><![CDATA[Oxford University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Knoepfler]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[A conversation with George Church on Genomics &amp; Germline Human Genetic Modification]]></source>
<year>2015</year>
<publisher-name><![CDATA[The Niche]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Genome editing: science, ethics, and public engagement]]></article-title>
<collab>The Lancet</collab>
<source><![CDATA[The Lancet]]></source>
<year>2017</year>
<volume>390</volume>
<page-range>625</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
