<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1886-5887</journal-id>
<journal-title><![CDATA[Revista de Bioética y Derecho]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Bioética y Derecho]]></abbrev-journal-title>
<issn>1886-5887</issn>
<publisher>
<publisher-name><![CDATA[Observatori de Bioètica i Dret - Cátedra UNESCO de Bioética]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1886-58872021000100005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El sesgo de publicación y la no reproducibilidad en el balance ético de los proyectos de investigación con animales]]></article-title>
<article-title xml:lang="en"><![CDATA[Publication bias and non-reproducibility in the ethical balance of animal research projects]]></article-title>
<article-title xml:lang="ca"><![CDATA[El biaix de publicació i la no reproducibilitat en el balanç ètic dels projectes de recerca amb animals]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigo Calduch]]></surname>
<given-names><![CDATA[Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universitat de Barcelona Comité Ético de Experimentación Animal ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<numero>51</numero>
<fpage>61</fpage>
<lpage>79</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1886-58872021000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1886-58872021000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1886-58872021000100005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La normativa que rige la investigación con animales establece la aprobación de proyectos de investigación tras haber sido sometidos a una valoración ética costes-beneficios apropiada. El sesgo de publicación y la falta de reproducibilidad en la investigación animal socavan el adecuado balance ético de los proyectos. Es necesario promover medidas que impliquen a todos los participantes (científicos, grupos editoriales, organismos gubernamentales y financiadores) y que generen un cambio en la cultura científica que revalorice los resultados negativos como parte del conocimiento científico general e incremente la calidad de las publicaciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Regulations governing animal research establish approval of research projects after having undergone a proper ethical harm-benefit assessment. Publication bias and lack of reproducibility in animal research undermine the proper ethical balance of projects. It is necessary to promote measures involving all participants (scientists, editorial groups, governmental and funder's agencies) to generate changes in the scientific culture in order to revalue negative results as part of general scientific knowledge and to increase quality of reports.]]></p></abstract>
<abstract abstract-type="short" xml:lang="ca"><p><![CDATA[Resum La normativa que regeix la recerca amb animals estableix l'aprovació de projectes de recerca després d'haver estat sotmesos a una valoració ètica de costos-beneficis apropiada. El biaix de publicació i la falta de reproducibilitat en la recerca animal soscaven l'adequat balanç ètic dels projectes. És necessari promoure mesures que impliquin a tots els participants (científics, grups editorials, organismes governamentals i finançadors) i que generin un canvi en la cultura científica que revalori els resultats negatius com a part del coneixement científic general i incrementi la qualitat de les publicacions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[investigación animal]]></kwd>
<kwd lng="es"><![CDATA[balance ético]]></kwd>
<kwd lng="es"><![CDATA[sesgo de publicación]]></kwd>
<kwd lng="es"><![CDATA[resultados negativos]]></kwd>
<kwd lng="es"><![CDATA[crisis de reproducibilidad]]></kwd>
<kwd lng="en"><![CDATA[animal research]]></kwd>
<kwd lng="en"><![CDATA[ethical balance]]></kwd>
<kwd lng="en"><![CDATA[publication bias]]></kwd>
<kwd lng="en"><![CDATA[negative results]]></kwd>
<kwd lng="en"><![CDATA[crisis of reproducibility]]></kwd>
<kwd lng="ca"><![CDATA[recerca animal]]></kwd>
<kwd lng="ca"><![CDATA[balanç ètic]]></kwd>
<kwd lng="ca"><![CDATA[biaix de publicació]]></kwd>
<kwd lng="ca"><![CDATA[resultats negatius]]></kwd>
<kwd lng="ca"><![CDATA[crisis de reproductibilitat]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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