<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1886-5887</journal-id>
<journal-title><![CDATA[Revista de Bioética y Derecho]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Bioética y Derecho]]></abbrev-journal-title>
<issn>1886-5887</issn>
<publisher>
<publisher-name><![CDATA[Observatori de Bioètica i Dret - Cátedra UNESCO de Bioética]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1886-58872021000100007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Retos de los Comités de Ética en Investigación en Animales. Experiencia de México]]></article-title>
<article-title xml:lang="en"><![CDATA[Challenges for Ethic Committees in Animal Research. Mexican experience]]></article-title>
<article-title xml:lang="ca"><![CDATA[Reptes dels Comitès d'Ética en Recerca en Animals. Experiència de Mèxic]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Heredia Antúnez]]></surname>
<given-names><![CDATA[Anayántzin Paulina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A1b"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vanda Cantón]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santillán-Doherty]]></surname>
<given-names><![CDATA[Patricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3b"/>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
</contrib>
</contrib-group>
<aff id="A1a">
<institution><![CDATA[,Consejo Nacional de Ciencia y Tecnología  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="A1b">
<institution><![CDATA[,Universidad Nacional Autónoma de México (UNAM)  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Departamento de de la Facultad de Medicina Veterinaria y Zootecnia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="A3a">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas"  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="A3b">
<institution><![CDATA[,Academia Mexicana de Cirugía  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="A3c">
<institution><![CDATA[,American Collegue of Surgeons  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="A3d">
<institution><![CDATA[,Sistema Nacional de Investigadores  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<numero>51</numero>
<fpage>99</fpage>
<lpage>121</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1886-58872021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1886-58872021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1886-58872021000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La aprobación de proyectos de investigación biomédica y prácticas en animales depende de los comités de ética para el cuidado y uso de animales, quienes deben evaluar los aspectos éticos y metodológicos de los proyectos que se realizan, y así garantizar el buen manejo y uso de los animales, desde su obtención hasta su muerte, con base en los conocimientos científicos actuales, el análisis riesgo-beneficio, la implementación de las Tres Erress que se refieren al reemplazo, reducción y refinamiento y en los criterios de la ciencia del bienestar animal. La atención a cada una de las etapas del diseño y evaluación de proyectos es a menudo subestimada tanto por los científicos como por los integrantes de comités, quienes deben asumir la responsabilidad de disminuir el dolor y el malestar de los animales a lo largo de la investigación. Por otro lado, se exponen algunas de las limitaciones que enfrentan dichos comités para realizar su trabajo y asegurar que los animales sean utilizados siempre y cuando se justifique.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The approval of the use of animals in biomedical research projects depends on the ethics committees for the care and use of laboratory animals, who must evaluate ethical and methodological aspects of the projects that are carried out and are intended to ensure the proper management and use of animals, from obtaining to death based on current scientific knowledge, risk-benefit analysis, the implementation of the three R's (3R's) applied to replacement, reduction and refinement, and the criteria of animal welfare science. Attention to each stage of project design and evaluation is often underestimated by both scientists and committee members, who must take responsibility for reducing pain and discomfort to animals throughout the investigation. On the other hand, some of the limitations that these committees face in carrying out their work and ensuring that animals are used are exposed as long as it is justified.]]></p></abstract>
<abstract abstract-type="short" xml:lang="ca"><p><![CDATA[Resum L'aprovació de projectes de recerca biomèdica i pràctiques en animals depèn dels comitès d'ètica per a la cura i ús d'animals, els qui han d'avaluar els aspectes ètics i metodològics dels projectes que es realitzen, i així garantir el bon maneig i ús dels animals, des de la seva obtenció fins a la seva mort, amb base en els coneixements científics actuals, l'anàlisi risc-beneficio, la implementació de les Tres Erress que es refereixen al reemplaçament, reducció i refinament i en els criteris de la ciència del benestar animal. L'atenció a cadascuna de les etapes del disseny i avaluació de projectes és sovint subestimada tant pels científics com pels integrants de comitès, els qui han d'assumir la responsabilitat de disminuir el dolor i el malestar dels animals al llarg de la recerca. D'altra banda, s'exposen algunes de les limitacions que enfronten aquests comitès per a fer el seu treball i assegurar que els animals siguin utilitzats sempre que es justifiqui.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[comités de ética para uso y cuidado de animales]]></kwd>
<kwd lng="es"><![CDATA[ética en investigación con animales]]></kwd>
<kwd lng="es"><![CDATA[análisis daño-beneficio]]></kwd>
<kwd lng="es"><![CDATA[bienestar animal]]></kwd>
<kwd lng="es"><![CDATA[investigación biomédica]]></kwd>
<kwd lng="en"><![CDATA[IACUC]]></kwd>
<kwd lng="en"><![CDATA[ethics in research]]></kwd>
<kwd lng="en"><![CDATA[risk-benefit analysis]]></kwd>
<kwd lng="en"><![CDATA[animal welfare]]></kwd>
<kwd lng="en"><![CDATA[animal research]]></kwd>
<kwd lng="ca"><![CDATA[comitès d'ètica per a ús i cura d'animals]]></kwd>
<kwd lng="ca"><![CDATA[ètica en recerca amb animals]]></kwd>
<kwd lng="ca"><![CDATA[anàlisi danyo-benefici]]></kwd>
<kwd lng="ca"><![CDATA[benestar animal]]></kwd>
<kwd lng="ca"><![CDATA[recerca biomèdica]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Adolphs]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A framework for studying emotions across species]]></article-title>
<source><![CDATA[Cell]]></source>
<year>2014</year>
<volume>157</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>187-200</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bateson]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[When to experiment on animals]]></article-title>
<source><![CDATA[New Scientist]]></source>
<year>1986</year>
<numero>109</numero>
<issue>109</issue>
<page-range>30-2</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Broom]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Welfare, stress, and the evolution of feelings]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Møller]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Milinski]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Slater]]></surname>
<given-names><![CDATA[PJB]]></given-names>
</name>
</person-group>
<source><![CDATA[Advances in the study of behavior]]></source>
<year>1998</year>
<volume>27</volume>
<page-range>371-403</page-range><publisher-name><![CDATA[Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Broom]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cognitive ability and awareness in domestic animals and decisions about obligations to animals]]></article-title>
<source><![CDATA[Applied Animal Behavior Science]]></source>
<year>2010</year>
<volume>126</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>1-11</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="book">
<collab>Canadian Council on Animal Care</collab>
<source><![CDATA[Policy Statement: Ethics of Animal Investigation]]></source>
<year>1989</year>
<publisher-loc><![CDATA[Ottawa ON ]]></publisher-loc>
<publisher-name><![CDATA[CCAC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="book">
<collab>Comisión Nacional de Bioética</collab>
<article-title xml:lang=""><![CDATA[Guía Nacional para la Integración y Funcionamiento de los Comités Hospitalarios de Bioética]]></article-title>
<source><![CDATA[]]></source>
<year>2016</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[Secretaría de Salud/ Comisión Nacional de Bioética]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="">
<collab>Diario Oficial de la Unión Europea</collab>
<source><![CDATA[Directiva 2010/63/UE del Parlamento Europeo y del Consejo, de 22 de septiembre relativa a la protección de los animales utilizados para fines científicos]]></source>
<year>2010</year>
<numero>L276</numero>
<issue>L276</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duncan]]></surname>
<given-names><![CDATA[IJH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The changing concept of animal sentience]]></article-title>
<source><![CDATA[Applied Animal Behaviour Science]]></source>
<year>2006</year>
<volume>100</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>11-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Heuze de Icaza]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El programa interno para el cuidado y uso de animales de laboratorio en las instituciones biomédicas docentes, de investigación científica e industria farmaceútica]]></article-title>
<source><![CDATA[Acta Bioethica]]></source>
<year>2007</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grimm]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Olsson]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Sandøe]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Harm-benefit analysis - what is the added value? A review of alternative strategies for weighing harms and benefits as part of the assessment of animal research]]></article-title>
<source><![CDATA[Laboratory animals]]></source>
<year>2019</year>
<volume>53</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>17-27</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<collab>Grupo de trabajo de expertos</collab>
<article-title xml:lang=""><![CDATA[Evaluación de proyectos y evaluación retrospectiva]]></article-title>
<source><![CDATA[Preocupándonos de los animales. Hacia una ciencia mejor]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Bruselas ]]></publisher-loc>
<publisher-name><![CDATA[Comisión Europea]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hansen]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Institution animal care and use committees need greater ethical diversity]]></article-title>
<source><![CDATA[Journal of medical ethics]]></source>
<year>2013</year>
<volume>39</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>188-90</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hasenau]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Honesty is the best policy]]></article-title>
<source><![CDATA[Lab animal]]></source>
<year>2018</year>
<volume>47</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>55</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Johansen]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Fields]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
<name>
<surname><![CDATA[Manning]]></surname>
<given-names><![CDATA[BH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex]]></article-title>
<source><![CDATA[Proceedings of the National Academy of Sciences]]></source>
<year>2001</year>
<volume>98</volume>
<numero>14</numero>
<issue>14</issue>
<page-range>8077-82</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Laber]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Newcomer]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
<name>
<surname><![CDATA[Decelle]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Everitt]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
<name>
<surname><![CDATA[Guillen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Brønstad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recommendations for Addressing Harm-Benefit Analysis and Implementation in Ethical Evaluation - Report from the AALAS-FELASA Working Group on Harm-Benefit Analysis - Part 2]]></article-title>
<source><![CDATA[Laboratory Animals]]></source>
<year>2016</year>
<volume>50</volume>
<numero>1_suppl</numero>
<issue>1_suppl</issue>
<page-range>21-42</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leyton]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ciencia y ética: acerca de la situación de los animales no humanos en la investigación]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Gallego]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chible]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Derecho Animal: Teoría y práctica]]></source>
<year>2018</year>
<page-range>289-311</page-range><publisher-loc><![CDATA[Chile ]]></publisher-loc>
<publisher-name><![CDATA[La Ley/Thomson Reuters]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Low]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Panksepp]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Reiss]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Edelman]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Van Swinderen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Low]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Koch]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Cambridge Declaration on Consciousness]]></source>
<year>2012</year>
<conf-name><![CDATA[ Francis Crick Memorial Conference on Consciousness in Human and non-Human Animals]]></conf-name>
<conf-loc>Cambridge, UK </conf-loc>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MacArthur Clark]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Guidelines for the ethical review of laboratory animal welfare People's Republic of China National Standard GB/T 35892-2018]]></article-title>
<source><![CDATA[Animal models and experimental medicine]]></source>
<year>2020</year>
<volume>3</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>103-13</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Magee]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Elwood]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Shock avoidance by discrimination learning in the shore crab (Carcinus maenas) is consistent with a key criterion for pain]]></article-title>
<source><![CDATA[Journal of Experimental Biology]]></source>
<year>2013</year>
<numero>216</numero>
<issue>216</issue>
<page-range>353-8</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mellor]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Affective States and the Assessment of Laboratory-Induced Animal Welfare Impacts]]></article-title>
<source><![CDATA[ALTEX Proceedings]]></source>
<year>2012</year>
<numero>1</numero>
<issue>1</issue>
<page-range>445-9</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="">
<source><![CDATA[Model Organisms for Biomedical Research | National Institute of Biomedical Imaging and Bioengineering. Nibib.nih.gov]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mohan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Huneke]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Role of IACUCs in Responsible Animal Research]]></article-title>
<source><![CDATA[ILAR journal]]></source>
<year>2019</year>
<volume>60</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>43-9</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morton]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Self-consciousness and animal suffering]]></article-title>
<source><![CDATA[Biologist (London, England)]]></source>
<year>2000</year>
<volume>47</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>77-80</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morton]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
<name>
<surname><![CDATA[Griffiths]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Guidelines on the recognition of pain, distress and discomfort in experimental animals and a hypothesis for assessment]]></article-title>
<source><![CDATA[The Veterinary record]]></source>
<year>1985</year>
<volume>116</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>431-6</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="book">
<collab>National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals</collab>
<source><![CDATA[Guide for the Care and Use of Laboratory Animals]]></source>
<year>2011</year>
<edition>8</edition>
<publisher-name><![CDATA[National Academies Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="">
<source><![CDATA[Office of Animal Care Compliance (OACC). Hsc.unm.edu]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="">
<collab>Organización Mundial de Sanidad Animal, OIE</collab>
<source><![CDATA[Utilización de animales en la investigación y educación, Código Sanitario para los Animales Terrestres]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Orlans]]></surname>
<given-names><![CDATA[FB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethical decision making about animal experiments]]></article-title>
<source><![CDATA[Ethics &amp; behavior]]></source>
<year>1997</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>163-71</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Panksepp]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The basic emotional circuits of mammalian brains: Do animals have affective lives?]]></article-title>
<source><![CDATA[Neuroscience and biobehavioral reviews]]></source>
<year>2011</year>
<volume>35</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1791-804</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez López]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[González Mateos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Camiña García]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández Moreno]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[La ética en la experimentación animal: El principio de las Tres Erress, Monografías do Ibader]]></source>
<year>2018</year>
<publisher-name><![CDATA[Ibader. Universidad de Santiago de Compostela]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ruiz de Chávez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La Comisión Nacional de Bioética y el caso de la investigación con animales]]></article-title>
<source><![CDATA[Gaceta de la Comisión Nacional de Bioética]]></source>
<year>2015</year>
<volume>IV</volume>
<page-range>3-4</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Russell]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Burch]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[The principles of humane experimental technique]]></source>
<year>1959</year>
</nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Russell]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Burch]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[The principles of humane experimental technique]]></source>
<year>1992</year>
<publisher-name><![CDATA[Universities Federation for Animal Welfare]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="">
<collab>Secretaría de Agricultura, Ganadería, Desarrollo Rural, Pesca y Alimentación (SAGARPA)</collab>
<source><![CDATA[Norma Oficial Mexicana NOM-062-ZOO-1999. Especificaciones técnicas para la producción, cuidado y uso de los animales de laboratorio]]></source>
<year>2001</year>
</nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="">
<source><![CDATA[Servicio Nacional de Sanidad, Inocuidad y Calidad Agroalimentaria (SENASICA) Directorio Nacional de Bioterios]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silverman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lidz]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
<name>
<surname><![CDATA[Clayfield]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Murray]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Maranda]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factors Influencing IACUC Decision Making: Who Leads the Discussions?]]></article-title>
<source><![CDATA[Journal of empirical research on human research ethics: JERHRE]]></source>
<year>2017</year>
<volume>12</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>209-16</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sneddon]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Elwood]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Adamo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Leach]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Defining and assessing animal pain]]></article-title>
<source><![CDATA[Animal Behaviour]]></source>
<year>2014</year>
<numero>97</numero>
<issue>97</issue>
<page-range>201-12</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Liberación animal]]></source>
<year>1999</year>
<edition>2</edition>
<publisher-loc><![CDATA[Valladolid ]]></publisher-loc>
<publisher-name><![CDATA[Trotta]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silverman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Post-publication problems: How to proceed when there's no record of IACUC approval?]]></article-title>
<source><![CDATA[Lab animal]]></source>
<year>2018</year>
<volume>47</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>53</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="">
<source><![CDATA[UNESCO. ESDAW]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Téllez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Vanda]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cuestionamientos éticos a la generación de conocimiento en la investigación biomédica con animales no humanos]]></article-title>
<source><![CDATA[Revista de Bioética y Bioderecho]]></source>
<year>2020</year>
<numero>49</numero>
<issue>49</issue>
<page-range>173-89</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The standardization of animals to improve biomedical research, production and control. Proceedings of a symposium, International Association of Biological Standardization, San Antonio, Texas, USA September 16-20, 1979]]></article-title>
<source><![CDATA[Developments in biological standardization]]></source>
<year>1980</year>
<numero>45</numero>
<issue>45</issue>
<page-range>3-247</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vanda]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Los principios bioéticos en nuestras relaciones con los animales]]></article-title>
<source><![CDATA[Perspectivas Bioéticas]]></source>
<year>2007</year>
<volume>12</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>77-88</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
