1887-8571 1887-8571 S1887-85712022000300004 0.4321/s1887-85712022000300004 España España España España España 00 09 2022 00 09 2022 78 3 146 150

1 2 2020 46 6 6 1127-53 3 2019 58 6 6 687-703 4 2007 13 2 2 154 5 2018 21 6 2016 27 5 5 605-14 7 2019 491 132-45 8 1998 17 8 8 1449-53 9 International Conference on Harmonisation of Tecnichal Requirements for Registration of Pharmaceutical Humans Use 2005 10 2007 852 1-2 1-2 223-8 11 2013 57 1 1 484-9