<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1887-8571</journal-id>
<journal-title><![CDATA[Sanidad Militar]]></journal-title>
<abbrev-journal-title><![CDATA[Sanid. Mil.]]></abbrev-journal-title>
<issn>1887-8571</issn>
<publisher>
<publisher-name><![CDATA[Ministerio de Defensa]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1887-85712023000200009</article-id>
<article-id pub-id-type="doi">10.4321/s1887-85712023000200009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carfentanilo: una doble amenaza para la salud pública]]></article-title>
<article-title xml:lang="en"><![CDATA[Carfentanil: a double threat to public health]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Repilado Álvarez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Urquía Grande]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Galdámez]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Llorente Ballesteros]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Toxicología de la Defensa.  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Toxicología de la Defensa Área de Cromatografía ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Toxicología de la Defensa  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto de Toxicología de la Defensa  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>79</volume>
<numero>2</numero>
<fpage>118</fpage>
<lpage>124</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1887-85712023000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1887-85712023000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1887-85712023000200009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El carfentanilo es un opioide sintético con una potencia 10.000 veces superior a la de la morfina. Esta y otras características posicionan al carfentanilo como una sustancia de interés dual, pues ha sido empleada como agente incapacitante y como droga de abuso. Entre las características toxicocinéticas del carfentanilo destacan su elevada liposolubilidad y la posibilidad de que siga una cinética de eliminación no lineal. En 2002 este compuesto fue empleado por las Fuerzas de Seguridad Rusas para intentar resolver la crisis de rehenes del teatro Dubrovka de Moscú, causando la muerte de al menos 123 rehenes. Por otro lado, el carfentanilo, se ha empleado como droga de abuso y como adulterante en otras drogas. En caso de intoxicación por carfentanilo puede ser necesaria la administración de dosis repetidas de antídoto. Los antecedentes expuestos en este trabajo justifican la necesidad de desarrollar y validar un método analítico para la detección del carfentanilo y su metabolito norcarfentanilo en muestras biológicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY Carfentanil is a synthetic opioid with a potency 10,000 times greater than that of morphine. For this and other reasons carfentanil is a substance with dual interest, since it has been used as an incapacitating agent and as an abuse drug. Among the toxicokinetic characteristics of carfentanil, its high lipid solubility stands out. In addition, there is the possibility that carfentanil follows a non-linear elimination kinetics. In 2002 this compound was used by the Russian Security Forces to try to resolve the hostage crisis at the Dubrovka theater in Moscow, causing the death of at least 123 hostages. On the other hand, carfentanil has been used as a drug of abuse and as an adulterant in other drugs. In case of carfentanil overdose, the administration of repeated doses of antidote may be necessary. The content of this review justifies the need to develop and validate an analytical method for the detection of carfentanil and its metabolite norcarfentanil in biological samples.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carfentanilo]]></kwd>
<kwd lng="es"><![CDATA[Toxicocinética]]></kwd>
<kwd lng="es"><![CDATA[Agente incapacitante]]></kwd>
<kwd lng="es"><![CDATA[Droga de abuso]]></kwd>
<kwd lng="es"><![CDATA[Adulterante]]></kwd>
<kwd lng="es"><![CDATA[Antídoto.]]></kwd>
<kwd lng="en"><![CDATA[Carfentanil]]></kwd>
<kwd lng="en"><![CDATA[Toxicokinetics]]></kwd>
<kwd lng="en"><![CDATA[Incapacitating agent]]></kwd>
<kwd lng="en"><![CDATA[Abuse drug]]></kwd>
<kwd lng="en"><![CDATA[Drug adulteration]]></kwd>
<kwd lng="en"><![CDATA[Antidote]]></kwd>
</kwd-group>
</article-meta>
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