<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1889-836X</journal-id>
<journal-title><![CDATA[Revista de Osteoporosis y Metabolismo Mineral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Osteoporos Metab Miner]]></abbrev-journal-title>
<issn>1889-836X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Investigaciones Óseas y Metabolismo Mineral]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1889-836X2017000200082</article-id>
<article-id pub-id-type="doi">10.4321/s1889-836x2017000200005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cribado y caracterización bioquímica del hiperparatiroidismo primario en Guayaquil (Ecuador)]]></article-title>
<article-title xml:lang="en"><![CDATA[Screening and biochemical characterization of primary hyperparathyroidism in Guayaquil (Ecuador)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[&#65279;López Gavilanez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerrero Franco]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Segale Bajaña]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solórzano Romero]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarro Chavez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Docente Policía Nacional Guayaquil Nº 2  ]]></institution>
<addr-line><![CDATA[Guayaquil ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Luis Vernaza Servicio Endocrinología ]]></institution>
<addr-line><![CDATA[Guayaquil ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>9</volume>
<numero>2</numero>
<fpage>82</fpage>
<lpage>88</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1889-836X2017000200082&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1889-836X2017000200082&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1889-836X2017000200082&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos: Objetivos: Conocer la prevalencia del hiperparatiroidismo primario (HPTP) mediante el cribado con la determinación de PTH y calcio iónico, en una muestra poblacional de Guayaquil (Ecuador).  Material y métodos: Estudio transversal, prospectivo, realizado entre el 1 enero de 2009 y el 30 noviembre de 2014, en 13.860 personas que acudieron a exámenes de control rutinarios. A todos se les determino en suero la hormona paratiroidea (PTH), el calcio iónico, la creatinina sérica y la 25(OH) vitamina D total (VD total). Se confirmó el diagnóstico de HPTP si el nivel de PTH y/o calcio iónico se mantenía elevado al menos en dos ocasiones diferentes. Se excluyeron los casos con elevación de la creatinina sérica, malabsorción, hepatopatías crónicas, insuficiencia de vitamina D, o los que recibían tratamientos que alteran el metabolismo fosfocálcico.  Resultados: Se encontró 61 casos con la PTH elevada al menos en dos ocasiones diferentes. Entre estos, 34 presentaban insuficiencia de vitamina D y fueron excluidos del análisis. En 27 casos (4 hombres y 23 mujeres) se confirmó el diagnóstico de HPTP. La edad media en mujeres fue de 64,5±15,4 años y en hombres de 71,3±12,8 años; los valores de PTH medios fueron 115±24,2 pg/ml; de calcio iónico, 5,15±0,4 mg/dl; de VD total, 47,1±20,2 ng/ml; y de creatinina sérica 0,84±0,2 mg/ml; La prevalencia de HPTP corresponde a 2 casos por mil adultos (IC 95%: 1,71-2,18). El mayor incremento en la prevalencia ocurrió en mujeres &#8805;60 años.  Conclusiones: En esta muestra, la prevalencia de HPTP es baja comparada con la reportada en series internacionales, siendo mayor en edades avanzadas y en mujeres. Con el cribado propuesto de PTH y calcio iónico encontramos en la mayoría de los casos la forma normocalcémica de HPTP.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objetives: To determine the prevalence of primary hyperparathyroidism (HPTP) using PTH and Ionic calcium screening in a population sample of Guayaquil (Ecuador).  Material and methods: Prospective, cross-sectional study carried out between January 1, 2009 and November 30, 2014 of 13,860 people who attended routine control tests. All were tested in serum parathyroid hormone (PTH), ionic calcium, serum creatinine and the 25 (OH) total vitamin D (total VD). The diagnosis of HPTP was confirmed if PTH or Ionic calcium levels remained high at least in two different occasions. We excluded patients with raised serum creatinine, vitamin D insufficiency, malabsorption, chronic liver disease, or those receiving treatments that alter phosphocalcic metabolism.  Results: 61 cases were found with raised PTH on at least two different occasions. Among these, 34 presented vitamin D insufficiency and were excluded from the analysis. In 27 cases (4 men and 23 women) the diagnosis of HPTP was confirmed. The average age for women was 64.5±15.4 years and men of 71.3±12.8 years; average PTH values were 115±24.2 pg/ml; Ionic calcium, 5.15±0.4 mg/dl; total VD, 47.1±20.2 ng/ml; and serum creatinine 0.84±0.2 mg/ml; prevalence of HPTP corresponds to 2 cases per thousand adults (95% CI: 1.71-2.18). The greatest increase in prevalence occurred in women aged 60 years.  Conclusions: PTH prevalence in this sample is low compared to that reported in international series, being higher in advanced ages and in women. With the proposed screening for PTH and ionic calcium, we detected the normocalcemic form of HPTP in most cases.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hiperparatiroidismo primario]]></kwd>
<kwd lng="es"><![CDATA[cribado]]></kwd>
<kwd lng="es"><![CDATA[calcio iónico]]></kwd>
<kwd lng="es"><![CDATA[prevalencia]]></kwd>
<kwd lng="es"><![CDATA[normocalcemia]]></kwd>
<kwd lng="es"><![CDATA[epidemiología]]></kwd>
<kwd lng="es"><![CDATA[vitamina D]]></kwd>
<kwd lng="en"><![CDATA[primary hyperparathyroidism]]></kwd>
<kwd lng="en"><![CDATA[screening]]></kwd>
<kwd lng="en"><![CDATA[ionic calcium]]></kwd>
<kwd lng="en"><![CDATA[prevalence]]></kwd>
<kwd lng="en"><![CDATA[normocalcemia]]></kwd>
<kwd lng="en"><![CDATA[epidemiology]]></kwd>
<kwd lng="en"><![CDATA[vitamin D]]></kwd>
</kwd-group>
</article-meta>
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