<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1889-836X</journal-id>
<journal-title><![CDATA[Revista de Osteoporosis y Metabolismo Mineral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Osteoporos Metab Miner]]></abbrev-journal-title>
<issn>1889-836X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Investigaciones Óseas y Metabolismo Mineral]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1889-836X2018000400005</article-id>
<article-id pub-id-type="doi">10.4321/s1889-836x2018000400005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores secretados por células óseas inducen acumulación de calcio intracelular y AMP cíclico y activación de ERK 1/2 en células de cáncer de próstata; evaluación por técnicas de fluorescencia en células vivas]]></article-title>
<article-title xml:lang="en"><![CDATA[Factors secreted by bone cells induce intracellular calcium accumulation and cyclic AMP and activation of ERK 1/2 in prostate cancer cells; evaluation by fluorescence techniques in living cells]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ardura]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez Rojas]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez Carrión]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Friedman]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alonso]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad San Pablo Instituto de Medicina Molecular Aplicada (IMMA) Laboratorio de Fisiopatología Ósea]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Universidad San Pablo-CEU Facultad de Medicina Departamento de Ciencias Médicas Básicas]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="A03">
<institution><![CDATA[,Universidad de Pittsburgh Departamento de Farmacología y Biología Química ]]></institution>
<addr-line><![CDATA[Pensilvania ]]></addr-line>
<country>Estados Unidos</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>10</volume>
<numero>4</numero>
<fpage>131</fpage>
<lpage>138</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1889-836X2018000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1889-836X2018000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1889-836X2018000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos: Analizar en células tumorales de próstata los efectos causados por el secretoma de células óseas sobre la proliferación y sobre vías de señalización intracelular relacionadas con la progresión del cáncer de próstata.  Material y métodos: Se caracterizaron los efectos de factores secretados presentes en medios condicionados de pre-osteoblastos MC3T3-E1 y osteocitos MLO-Y4 sobre la proliferación de células de adenocarcinoma de próstata metastásicas PC-3 mediante tinción por azul de tripano. Se observó por técnicas de fluorescencia en células vivas los efectos de los medios condicionados por células MC3T3-E1 y MLO-Y4 en moléculas de señalización intracelular implicadas en la progresión tumoral de células de adenocarcinoma de próstata PC-3. Se estudió la acumulación de calcio intracelular utilizando el indicador de calcio fluorescente Fluo-4AM y la generación de AMP cíclico, y la activación de la quinasa ERK 1/2 por Transferencia de Energía de Resonancia Fluorescente (FRET) usando los biosensores EPAC y ERK-NES, respectivamente.  Resultados: La estimulación de células PC-3 con medios condicionados de pre-osteoblastos MC3T3-E1 y osteocitos MLO-Y4 indujo aumento en la proliferación de las células de adenocarcinoma PC-3. Los medios condicionados por células óseas causaron también aumento transitorio en la acumulación de calcio intracelular y de la generación de AMP cíclico e incrementaron la activación de la quinasa ERK 1/2.  Conclusiones: Las células óseas secretan factores activadores de la proliferación y de vías de señalización que favorecen la progresión tumoral de células de cáncer de próstata, sugiriendo que la comunicación cruzada entre estos tipos celulares puede favorecer el desarrollo de nichos metástasicos de cáncer de próstata en el hueso.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary  Objective: To analyze in prostate tumor cells the effects caused by the secretome of bone cells on proliferation and on intracellular signaling pathways related to the progression of prostate cancer.  Materials and methods: The effects of secreted factors present in conditioned media of pre-osteoblasts MC3T3-E1 and osteocytes MLO-Y4 on the proliferation of metastatic prostate adenocarcinoma cells PC-3 were characterized using trypan blue staining. The effects of media conditioned by MC3T3-E1 and MLO-Y4 cells on intracellular signaling molecules involved in the tumor progression of prostate adenocarcinoma cells PC-3 were observed by fluorescence techniques in living cells. The accumulation of intracellular calcium was studied using the fluorescent calcium indicator Fluo-4AM and the generation of cyclic AMP, and ERK 1/2 activation by Fluorescent Resonance Energy Transfer (FRET) using the EPAC and ERK-NES biosensors, respectively.  Results: The stimulation of PC-3 cells with conditioned media of pre-osteoblasts MC3T3-E1 and osteocytes MLO-Y4 induced an increase in PC-3 adenocarcinoma cell proliferation. Media conditioned by bone cells also caused a transient increase in intracellular calcium accumulation and generation of cyclic AMP and increased ERK 1/2 activation.  Conclusions: Bone cells secrete proliferation-activating factors and signaling pathways that favor the tumor progression of prostate cancer cells, suggesting that cross-communication between these cell types may favor the development of metastatic niches of prostate cancer in the bone.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[cáncer de próstata]]></kwd>
<kwd lng="es"><![CDATA[factores secretados óseos]]></kwd>
<kwd lng="es"><![CDATA[señalización intracelular]]></kwd>
<kwd lng="es"><![CDATA[fluorescencia en células vivas]]></kwd>
<kwd lng="es"><![CDATA[calcio]]></kwd>
<kwd lng="es"><![CDATA[AMP cíclico]]></kwd>
<kwd lng="es"><![CDATA[ERK 1/2]]></kwd>
<kwd lng="en"><![CDATA[prostate cancer]]></kwd>
<kwd lng="en"><![CDATA[secreted bone factors]]></kwd>
<kwd lng="en"><![CDATA[intracellular signaling]]></kwd>
<kwd lng="en"><![CDATA[fluorescence in living cells]]></kwd>
<kwd lng="en"><![CDATA[calcium]]></kwd>
<kwd lng="en"><![CDATA[cyclic AMP]]></kwd>
<kwd lng="en"><![CDATA[ERK 1/2]]></kwd>
</kwd-group>
</article-meta>
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