<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1889-836X</journal-id>
<journal-title><![CDATA[Revista de Osteoporosis y Metabolismo Mineral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Osteoporos Metab Miner]]></abbrev-journal-title>
<issn>1889-836X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Investigaciones Óseas y Metabolismo Mineral]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1889-836X2019000100003</article-id>
<article-id pub-id-type="doi">10.4321/s1889-836x2019000100003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectos de la estimulación mecánica en la comunicación entre células óseas]]></article-title>
<article-title xml:lang="en"><![CDATA[Effects of mechanical stimulation on communication between bone cells]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cadenas Martín]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tirado]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
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</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
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<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ardura]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
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<xref ref-type="aff" rid="A a"/>
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<contrib contrib-type="author">
<name>
<surname><![CDATA[Bravo]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
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<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gortazar]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad San Pablo-CEU Instituto de Medicina Aplicada ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Universidad San Pablo CEU Facultad de Medicina Departamento de Ciencias Médicas Básicas]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>11</volume>
<numero>1</numero>
<fpage>12</fpage>
<lpage>18</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1889-836X2019000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1889-836X2019000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1889-836X2019000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La fuerza mecánica es importante para el modelado, el remodelado y la regeneración ósea; estimula a los osteocitos provocando una alteración en la producción y secreción de moléculas de señalización que regulan la actividad de los osteoblastos y los osteoclastos. El objetivo del presente estudio fue evaluar el efecto del medio condicionado de células osteocíticas de ratón estimuladas mecánicamente sobre la capacidad proliferativa y migratoria de células mesenquimales y células óseas. Para ello, se analizó la proliferación y migración de las células preosteoblásticas de ratón, células mesenquimales preadiposas humanas y macrófagos de ratón en presencia del medio condicionado de las células osteocíticas, tras 6 y 24 horas después de ser sometidas a un estrés mecánico de 10 dinas/cm2 por flujo de fluido (FF) durante 10 minutos. Se encontró que la migración de células preosteoblásticas aumentó significativamente en presencia de medios condicionados de células osteocíticas con respecto al grupo control estático (SC) (SC=12,63±5,44; FF6h=23,03±11,57; FF24h=29,72±15,76; p&lt;0,0001). De la misma manera, las células preadiposas también incrementaron significativamente su migración en presencia de dichos medios condicionados (SC=11,48±4,75; FF6h=18,43±9,94; FF24h=18,80±10,03; p&#8804;0,0007). Sin embargo, la migración de los macrófagos disminuyó en presencia del medio condicionado recogido a las 24 horas con respecto al grupo control estático (SC=69±22,71; FF24h=26,57±5,47; p&lt;0,0001). Estos efectos se asociaron con la disminución de la expresión proteica de ciertas quimioquinas, como la proteína quimiotáctica de monocitos de tipo I (SC=0,25±0,06; FF24h=0,09±0,005; p=0,0262), la proteína del grupo I de alta movilidad (SC=0,25±0,04; FF24h=0,15±0,05; p=0,0159) y la proteína reguladora de la activación de linfocitos T y monocitos (SC=3,29±0,88; FF6h=1,33±1,09; FF24h=0,97±0,66; p&#8804;0,0314), por parte de los osteocitos en presencia de estímulo mecánico con respecto al grupo control estático. En conclusión, este estudio in vitro demuestra que la mecanotransducción de los osteocitos potencia el reclutamiento de osteoblastos y células mesenquimales preadiposas mientras que reduce la migración de los macrófagos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary Mechanical force is important for modeling, remodeling and bone regeneration. It stimulates the osteocytes, causing an alteration in the production and secretion of signaling molecules that regulate osteoblast and osteoclast activity. The present study aims to evaluate the effect of the conditioned medium of mechanically stimulated mouse osteocytic cells on the proliferative and migratory capacity of mesenchymal cells and bone cells. For this, the proliferation and migration of mouse pre-osteoblastic cells, human pre-adult mesenchymal cells and mouse macrophages in the presence of the conditioned medium of osteocytic cells were analyzed, after 6 and 24 hours after being subjected to a mechanical stress of 10 dynes/cm2 by fluid flow (FF) for 10 minutes. The migration of pre-osteoblastic cells has been found to increase significantly in the presence of conditioned media of osteocytic cells compared to the static control group (SC) (SC=12.63±5.44, FF6h=23.03±11.57, FF24h=29.72±15.76, p&lt;0.0001). In the same way, the pre-adipose cells also significantly increased their migration in the presence of this conditioned media (SC=11.48±4.75, FF6h=18.43±9.94, FF24h=18.80±10.03; p&#8804;0.0007). However, macrophage migration decreased in the presence of the conditioned medium collected at 24 hours with respect to the static control group (SC=69±22.71, FF24h=26.57±5.47, p&lt;0.0001). These effects were associated with decreased protein expression of certain chemokines, such as the monocyte chemotactic protein type I (SC=0.25±0.06, FF24h=0.09±0.005, p=0.0262), the protein of group I of high mobility (SC=0.25±0.04, FF24h=0.15±0.05, p=0.0159) and the regulatory protein of the activation of T lymphocytes and monocytes (SC=3.29±0.88, FF6h=1.33±1.09, FF24h=0.97±0.66, p&#8804;0.0314), by the osteocytes in the presence of mechanical stimulation with respect to the static control group. In conclusion, this in vitro study demonstrates that osteocyte mechanotransduction enhances recruitment of osteoblasts and pre-adipose mesenchymal cells while reducing the migration of macrophages.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[osteocitos]]></kwd>
<kwd lng="es"><![CDATA[osteoblastos]]></kwd>
<kwd lng="es"><![CDATA[macrófagos]]></kwd>
<kwd lng="es"><![CDATA[células mesenquimales]]></kwd>
<kwd lng="es"><![CDATA[estimulación mecánica]]></kwd>
<kwd lng="es"><![CDATA[quimioquinas]]></kwd>
<kwd lng="en"><![CDATA[osteocytes]]></kwd>
<kwd lng="en"><![CDATA[osteoblasts]]></kwd>
<kwd lng="en"><![CDATA[macrophages]]></kwd>
<kwd lng="en"><![CDATA[mesenchymal cells]]></kwd>
<kwd lng="en"><![CDATA[mechanical stimulation]]></kwd>
<kwd lng="en"><![CDATA[chemokines]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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